Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Sigma A6730 | BT-474 | -4.1759 | 0.9396 | -5.4899 | -5.4902 | -6.1896 | 0.7437 | 0.0000 | 0.0953 | 6.2760 |
| Omipalisib | MDA-MB-134-VI | -4.4776 | 0.9885 | -7.2176 | -7.2177 | -7.9713 | 0.7442 | 0.0000 | 0.0092 | 4.4619 |
| Omipalisib | 184B5 | -4.4776 | 0.9563 | -7.9406 | -7.6231 | -8.2450 | 0.7444 | 0.2099 | 0.2120 | 4.7470 |
| Taxol | HCC202 | -4.4776 | 0.8745 | -7.6526 | -4.4776 | -8.0799 | 0.7451 | 0.5002 | 0.5024 | 6.4149 |
| Omipalisib | BT-549 | -4.4776 | 0.9671 | -7.4066 | -7.1032 | -7.3547 | 0.7457 | 0.2033 | 0.2085 | 5.3689 |
| Pevonedistat | MCF7 | -4.1759 | 0.9836 | -6.4399 | -6.1838 | -7.1668 | 0.7465 | 0.1781 | 0.1945 | 5.8664 |
| Ibandronate | MCF 10F | -2.8239 | 0.8695 | -3.5859 | -3.2635 | -3.8306 | 0.7470 | 0.2128 | 0.3800 | 7.7782 |
| Etoposide | HCC1954 | -3.4776 | 0.9477 | -5.7446 | -5.7342 | -6.1019 | 0.7475 | 0.0099 | 0.0325 | 5.1728 |
| 5-FU | MCF 10A | -1.7167 | 0.9875 | -4.6117 | -4.6114 | -4.8502 | 0.7477 | 0.0000 | 0.0079 | 4.0421 |
| Sigma A6730 | SUM225CWN | -4.1759 | 0.8847 | -5.5194 | -5.5195 | -6.3932 | 0.7481 | 0.0000 | 0.0922 | 6.1228 |
| Tozasertib | MDA-MB-453 | -4.0000 | 0.8180 | -4.7763 | -4.7762 | -5.2841 | 0.7487 | 0.0000 | 0.2078 | 6.9240 |
| GSK1059615 | BT-483 | -3.8761 | 0.9638 | -6.0801 | -5.6847 | -6.8353 | 0.7491 | 0.2470 | 0.2635 | 6.3311 |
| Bosutinib | MCF7 | -4.0000 | 0.8507 | -5.8570 | -4.1284 | -5.6468 | 0.7495 | 0.4747 | 0.4952 | 7.2106 |
| 5-FU | BT-474 | -1.7167 | 0.9589 | -2.9757 | -2.7833 | -3.7369 | 0.7497 | 0.1304 | 0.2255 | 7.0657 |
| Ibandronate | HCC1143 | -2.8239 | 0.9761 | -4.1079 | -4.0126 | -4.4078 | 0.7501 | 0.0759 | 0.1666 | 6.8265 |
| Doxorubicin | HCC70 | -6.2596 | 0.8984 | -5.8822 | -6.2596 | -7.3316 | 0.7514 | 0.0000 | 0.6576 | 8.3593 |
| (Z)-4-Hydroxytamoxifen | SUM229PE | -3.7773 | 0.8805 | -5.0583 | -5.0581 | -5.4005 | 0.7517 | 0.0000 | 0.0982 | 6.9534 |
| Ispinesib | MDA-MB-175-VII | -4.4776 | 0.8011 | -5.2565 | -5.2564 | -6.0577 | 0.7518 | 0.0000 | 0.2062 | 6.8961 |
| Epirubicin | HCC1569 | -3.7645 | 0.9012 | -5.9645 | -5.8433 | -6.1287 | 0.7519 | 0.1000 | 0.1219 | 5.8298 |
| Epirubicin | HCC2185 | -3.7645 | 0.9847 | -5.5875 | -5.5878 | -6.8186 | 0.7520 | 0.0000 | 0.0408 | 5.9682 |
| Bortezomib | MCF 10F | -3.7773 | 0.9879 | -6.4513 | -6.4518 | -6.9070 | 0.7522 | 0.0000 | 0.0096 | 4.6275 |
| Lestaurtinib | SK-BR-3 | -4.4776 | 0.9345 | -5.4494 | -5.4494 | -5.9986 | 0.7525 | 0.0000 | 0.1566 | 6.9315 |
| Afatinib | BT-474 | -4.1759 | 0.9561 | -7.7189 | -7.6261 | -8.2964 | 0.7528 | 0.0745 | 0.0764 | 3.8218 |
| Triciribine | AU565 | -4.4776 | 0.9816 | -7.3716 | -7.3323 | -7.6135 | 0.7532 | 0.0324 | 0.0389 | 4.5358 |
| Trametinib | SUM1315MO2 | -4.7773 | 0.8461 | -6.6293 | -4.8677 | -6.9874 | 0.7539 | 0.5155 | 0.5867 | 7.5543 |