Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Ispinesib | MCF12A | -4.4776 | 0.9360 | -7.1016 | -7.0657 | -7.3108 | 1.7331 | 0.0940 | 0.1136 | 5.2186 |
| Ispinesib | HCC1143 | -4.4776 | 0.9009 | -7.3106 | -7.2277 | -7.3096 | 3.9990 | 0.2676 | 0.2676 | 5.7668 |
| Omipalisib | HCC1395 | -4.4776 | 0.9674 | -7.0311 | -6.6125 | -7.3086 | 0.9230 | 0.2903 | 0.2936 | 6.1517 |
| Epirubicin | MCF12A | -3.7645 | 0.9770 | -7.0825 | -7.0822 | -7.3078 | 0.8421 | 0.0000 | 0.0016 | 3.7649 |
| Doxorubicin | HCC1806 | -6.2596 | 0.9360 | -6.9901 | -6.9901 | -7.3056 | 1.2590 | 0.0000 | 0.1493 | 7.3923 |
| Triciribine | SK-BR-3 | -4.4776 | 0.9794 | -7.1261 | -7.0205 | -7.3056 | 1.0085 | 0.1086 | 0.1106 | 5.1406 |
| Topotecan | HCC2185 | -3.9626 | 0.8939 | -6.3376 | -3.9626 | -7.3028 | 0.7330 | 0.5374 | 0.5407 | 6.9119 |
| GSK923295 | BT-549 | -4.4776 | 0.9726 | -7.3356 | -7.2273 | -7.2973 | 3.9990 | 0.3149 | 0.3149 | 6.0724 |
| Vinorelbine | BT-474 | -4.3335 | 0.8757 | -6.4655 | -6.4650 | -7.2884 | 0.3937 | 0.0000 | 0.1265 | 5.4541 |
| 17-AAG | HCC38 | -4.0000 | 0.9507 | -7.0200 | -6.8296 | -7.2836 | 1.4475 | 0.2327 | 0.2334 | 5.4493 |
| Bortezomib | HCC38 | -3.7773 | 0.9900 | -7.1958 | -7.1957 | -7.2796 | 3.4400 | 0.0004 | 0.0004 | 3.6395 |
| Pevonedistat | MDA-MB-157 | -4.1759 | 0.9626 | -7.0049 | -6.6396 | -7.2785 | 0.7059 | 0.2237 | 0.2314 | 5.4395 |
| 17-AAG | MDA-MB-361 | -4.0000 | 0.9853 | -7.1865 | -7.1428 | -7.2781 | 3.9990 | 0.1527 | 0.1527 | 4.8491 |
| MG-132 | BT-20 | -4.1759 | 0.8406 | -7.0069 | -6.9822 | -7.2724 | 2.7675 | 0.0756 | 0.0756 | 4.5551 |
| Ispinesib | BT-474 | -4.4776 | 0.9278 | -6.3866 | -6.3865 | -7.2715 | 0.6841 | 0.0000 | 0.0483 | 5.9228 |
| Fascaplysin | SUM225CWN | -4.4776 | 0.9848 | -6.9386 | -6.9375 | -7.2700 | 1.8930 | 0.0038 | 0.0048 | 4.9975 |
| Topotecan | MCF 10A | -3.9626 | 0.9780 | -6.9901 | -6.9901 | -7.2644 | 0.6104 | 0.0000 | 0.0141 | 4.1275 |
| Fascaplysin | SUM185PE | -4.4776 | 0.9796 | -6.8116 | -6.8116 | -7.2637 | 1.2950 | 0.0000 | 0.0009 | 5.0270 |
| Topotecan | SUM229PE | -3.9626 | 0.9297 | -7.1491 | -6.9775 | -7.2598 | 1.5005 | 0.2239 | 0.2239 | 5.0421 |
| Geldanamycin | LY2 | -4.0000 | 0.9799 | -7.1510 | -6.9067 | -7.2580 | 1.4390 | 0.2755 | 0.2755 | 5.4539 |
| Erlotinib | MB 157 | -4.1759 | 0.7903 | -6.8039 | -6.5862 | -7.2524 | 0.3761 | 0.0860 | 0.1711 | 5.0635 |
| Lestaurtinib | HCC38 | -4.4776 | 0.9876 | -7.1366 | -7.1218 | -7.2491 | 1.9080 | 0.0305 | 0.0305 | 4.7421 |
| Doxorubicin | T47D | -6.2596 | 0.8913 | -6.4580 | -6.4460 | -7.2470 | 0.8943 | 0.0146 | 0.3997 | 8.1427 |
| LBH589 | SK-BR-3 | -4.4776 | 0.9866 | -7.1326 | -7.1301 | -7.2387 | 3.8280 | 0.0109 | 0.0109 | 4.8858 |
| Bortezomib | CAMA-1 | -3.7773 | 0.9821 | -7.0033 | -6.9897 | -7.2385 | 2.0380 | 0.0287 | 0.0287 | 3.9290 |