Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Taxol | UACC-893 | -4.4776 | 0.8644 | -7.7571 | -6.0194 | -7.8858 | 3.3115 | 0.5061 | 0.5061 | 7.1464 |
| Geldanamycin | HCC2185 | -4.0000 | 0.9492 | -7.7050 | -7.5465 | -7.8857 | 2.8510 | 0.3693 | 0.3693 | 5.2148 |
| Taxol | T47DKBLUC | -4.4776 | 0.9657 | -7.7956 | -7.1535 | -7.8857 | 1.9630 | 0.4725 | 0.4725 | 6.3425 |
| Geldanamycin | BT-474 | -4.0000 | 0.9824 | -7.7705 | -7.6527 | -7.8856 | 3.5905 | 0.3031 | 0.3031 | 5.0989 |
| Vinorelbine | MCF 10F | -4.3335 | 0.8616 | -7.8480 | -7.6827 | -7.8817 | 3.1090 | 0.3278 | 0.3278 | 5.3146 |
| Vinorelbine | MCF7 | -4.3335 | 0.8379 | -7.5265 | -7.3826 | -7.8807 | 1.0510 | 0.1576 | 0.2011 | 4.8392 |
| Vinorelbine | SUM149PT | -4.3335 | 0.9420 | -7.8895 | -7.8406 | -7.8780 | 3.9990 | 0.1822 | 0.1822 | 4.4555 |
| Trametinib | MDA-MB-175-VII | -4.7773 | 0.9370 | -7.3673 | -6.2037 | -7.8746 | 0.8195 | 0.4444 | 0.4486 | 6.7305 |
| Topotecan | MB 157 | -3.9626 | 0.9843 | -7.1696 | -7.1692 | -7.8725 | 0.9499 | 0.0000 | 0.0009 | 3.8081 |
| GSK923295 | MDA-MB-468 | -4.4776 | 0.8812 | -7.7266 | -7.6512 | -7.8595 | 1.7550 | 0.1626 | 0.1626 | 4.6745 |
| GSK461364 | Hs 578T | -4.4776 | 0.9074 | -7.7706 | -7.6340 | -7.8504 | 2.5630 | 0.2968 | 0.2968 | 5.2331 |
| Taxol | MCF7 | -4.4776 | 0.9768 | -7.8906 | -7.1065 | -7.8335 | 1.6440 | 0.4743 | 0.4743 | 6.1682 |
| Taxol | HCC1937 | -4.4776 | 0.8964 | -7.7206 | -4.4776 | -7.8332 | 1.5660 | 0.5548 | 0.5548 | 6.8888 |
| Taxol | HCC1143 | -4.4776 | 0.9579 | -7.6816 | -7.4738 | -7.8328 | 1.7125 | 0.2784 | 0.2784 | 5.4383 |
| Taxol | MDA-MB-361 | -4.4776 | 0.9721 | -7.7206 | -7.0959 | -7.8297 | 1.4295 | 0.4323 | 0.4323 | 6.0960 |
| Geldanamycin | UACC-812 | -4.0000 | 0.9479 | -7.6900 | -7.4889 | -7.8250 | 3.4085 | 0.3924 | 0.3924 | 5.5975 |
| Ispinesib | BT-20 | -4.4776 | 0.9307 | -7.6586 | -7.5079 | -7.8227 | 2.0120 | 0.2162 | 0.2162 | 5.0491 |
| 17-AAG | HCC202 | -4.0000 | 0.8793 | -6.3950 | -6.1120 | -7.8220 | 0.4610 | 0.1621 | 0.2232 | 5.7129 |
| Trametinib | HCC70 | -4.7773 | 0.8905 | -8.2518 | -4.7773 | -7.8153 | 0.7067 | 0.6011 | 0.6025 | 7.4155 |
| MG-132 | 184B5 | -4.1759 | 0.9692 | -7.6379 | -7.5323 | -7.8110 | 1.3330 | 0.1381 | 0.1381 | 4.3089 |
| Geldanamycin | MDA-MB-175-VII | -4.0000 | 0.9905 | -7.6860 | -7.5417 | -7.8110 | 2.9170 | 0.3107 | 0.3107 | 4.9876 |
| 17-AAG | BT-474 | -4.0000 | 0.9618 | -7.4900 | -7.3357 | -7.8068 | 1.8840 | 0.2443 | 0.2443 | 5.7024 |
| 17-AAG | SUM1315MO2 | -4.0000 | 0.8799 | -6.6145 | -6.5024 | -7.8064 | 1.2761 | 0.1652 | 0.2197 | 5.5249 |
| Docetaxel | MDA-MB-175-VII | -5.0000 | 0.8165 | -8.0975 | -5.0000 | -7.8058 | 2.7620 | 0.7630 | 0.7630 | 7.7847 |
| Geldanamycin | T47D | -4.0000 | 0.9769 | -7.6310 | -7.4618 | -7.8048 | 3.1990 | 0.3566 | 0.3566 | 5.2630 |