Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| NSC 663284 | CAMA-1 | -3.7773 | 0.9767 | -5.4553 | -5.4544 | -5.6787 | 2.3970 | 0.0081 | 0.0081 | 5.9559 |
| CGC-11144 | CAMA-1 | -3.1500 | 0.9865 | -6.0860 | -6.0621 | -6.5516 | 0.9931 | 0.0269 | 0.0280 | 4.3835 |
| Geldanamycin | CAMA-1 | -4.0000 | 0.9505 | -7.5310 | -4.0000 | -7.5512 | 1.8140 | 0.5276 | 0.5276 | 6.4380 |
| Topotecan | CAMA-1 | -3.9626 | 0.8431 | -5.1246 | -5.1243 | -6.3233 | 0.4322 | 0.0000 | 0.2394 | 6.6657 |
| GSK1059615 | CAMA-1 | -3.8761 | 0.9730 | -5.5201 | -5.3972 | -5.8029 | 1.1190 | 0.1362 | 0.1485 | 6.5521 |
| AG1478 | CAMA-1 | -3.7773 | 0.9699 | -4.3808 | -4.3485 | -4.4601 | 3.9990 | 0.1285 | 0.1319 | 7.9986 |
| Temsirolimus | CAMA-1 | -3.8761 | 0.9061 | -6.1471 | -6.1472 | -7.3708 | 0.3358 | 0.0000 | 0.1473 | 5.1614 |
| Oxamflatin | CAMA-1 | -4.1759 | 0.9615 | -5.8954 | -5.8751 | -6.1584 | 2.1740 | 0.0453 | 0.0455 | 5.9953 |
| Trichostatin A | CAMA-1 | -2.3010 | 0.9721 | -5.0370 | -5.0141 | -5.1708 | 4.0000 | 0.0963 | 0.0963 | 4.8347 |
| Gefitinib | CAMA-1 | -4.4776 | 0.7673 | -4.6501 | -4.4776 | -4.6796 | 3.9950 | 0.3020 | 0.6232 | 8.7188 |
| Nutlin 3a | CAMA-1 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.0974 |
| 5-DFUR | CAMA-1 | -2.3010 | 0.8488 | -3.4620 | -2.3010 | -3.7320 | 0.5666 | 0.4131 | 0.5189 | 7.2984 |
| Cisplatin | CAMA-1 | -3.6021 | 0.9651 | -4.1687 | -4.1686 | -4.4034 | 2.3580 | 0.0000 | 0.0441 | 7.6701 |
| Trametinib | CAMA-1 | -4.7773 | 0.7059 | -5.8873 | -4.7773 | -4.7773 | 0.5843 | 0.7967 | 0.8340 | 8.4439 |
| GSK1838705A | CAMA-1 | -4.1759 | 0.9785 | -5.2734 | -5.2637 | -5.3798 | 3.9990 | 0.0436 | 0.0436 | 6.9684 |
| GSK1070916 | CAMA-1 | -4.4776 | 0.9256 | -4.6946 | -4.6945 | -5.0755 | 1.3570 | 0.0000 | 0.3367 | 7.9134 |
| Omipalisib | CAMA-1 | -4.4776 | 0.9464 | -6.7651 | -6.7125 | -7.1194 | 1.3345 | 0.0749 | 0.0757 | 5.5519 |
| Oxaliplatin | CAMA-1 | -3.2013 | 0.9502 | -4.4623 | -4.4628 | -5.1725 | 0.8741 | 0.0000 | 0.0732 | 6.4223 |
| 5-FU | CAMA-1 | -1.7167 | 0.8554 | -2.8017 | -2.6620 | -3.6658 | 0.5456 | 0.0805 | 0.2678 | 6.8685 |
| Pevonedistat | CAMA-1 | -4.1759 | 0.9062 | -7.1969 | -6.7206 | -7.3820 | 1.5490 | 0.4241 | 0.4260 | 6.0696 |
| PD173074 | CAMA-1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Ispinesib | CAMA-1 | -4.4776 | 0.9764 | -7.5631 | -7.5265 | -7.6633 | 3.6505 | 0.1281 | 0.1281 | 4.6158 |
| Erlotinib | CAMA-1 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.9862 |
| Sunitinib | CAMA-1 | -3.7773 | 0.9798 | -4.9863 | -4.9856 | -5.0970 | 4.0000 | 0.0030 | 0.0031 | 6.6815 |
| IKK16 | CAMA-1 | -4.1759 | 0.9341 | -5.4409 | -5.4409 | -5.5702 | 2.7570 | 0.0000 | 0.0003 | 6.4513 |