Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Vinorelbine | HCC1806 | -4.3335 | 0.9910 | -8.2425 | -8.2240 | -8.2912 | 3.8810 | 0.0763 | 0.0763 | 3.3665 |
| Ixabepilone | SUM159PT | -4.4045 | 0.9785 | -8.1955 | -8.1674 | -8.2110 | 1.8280 | 0.0548 | 0.0548 | 3.3677 |
| Geldanamycin | MCF 10F | -4.0000 | 0.9860 | -8.1020 | -8.0697 | -8.1444 | 2.7410 | 0.0931 | 0.0931 | 3.3677 |
| CGC-11144 | HCC1143 | -3.1500 | 0.9895 | -6.7860 | -6.7811 | -6.9109 | 1.8010 | 0.0109 | 0.0109 | 3.3702 |
| Vinorelbine | BT-549 | -4.3335 | 0.9427 | -8.0965 | -8.0750 | -8.1222 | 3.2750 | 0.0776 | 0.0776 | 3.3764 |
| Bortezomib | T47D | -3.7773 | 0.9910 | -7.3053 | -7.3057 | -7.4319 | 3.2440 | 0.0000 | 0.0000 | 3.3783 |
| Bortezomib | SUM159PT | -3.7773 | 0.9754 | -7.3913 | -7.3915 | -7.4495 | 1.5190 | 0.0000 | 0.0000 | 3.3800 |
| Vinorelbine | SUM159PT | -4.3335 | 0.9046 | -7.9905 | -7.9804 | -7.9945 | 3.9975 | 0.0445 | 0.0445 | 3.3893 |
| CGC-11144 | HCC38 | -3.1500 | 0.9888 | -6.7130 | -6.7121 | -6.8404 | 2.3370 | 0.0077 | 0.0077 | 3.4151 |
| Vinorelbine | AU565 | -4.3335 | 0.9787 | -8.2355 | -8.2178 | -8.2931 | 3.9965 | 0.0760 | 0.0760 | 3.4210 |
| Ixabepilone | MB 157 | -4.4045 | 0.9839 | -8.1805 | -8.1609 | -8.2593 | 2.0130 | 0.0444 | 0.0444 | 3.4312 |
| Bortezomib | HCC202 | -3.7773 | 0.9805 | -7.4423 | -7.4370 | -7.6511 | 3.9990 | 0.0253 | 0.0253 | 3.4375 |
| Bortezomib | MDA-MB-157 | -3.7773 | 0.9927 | -7.3033 | -7.3015 | -7.4332 | 3.1570 | 0.0074 | 0.0074 | 3.4694 |
| Ixabepilone | BT-549 | -4.4045 | 0.9627 | -8.2475 | -8.2134 | -8.2899 | 1.4985 | 0.0563 | 0.0563 | 3.4712 |
| CGC-11144 | HCC1954 | -3.1500 | 0.9450 | -6.5110 | -6.5077 | -6.6591 | 2.6450 | 0.0068 | 0.0068 | 3.4764 |
| Torkinib | MDA-MB-134-VI | -4.3010 | 0.9644 | -8.3700 | -8.1441 | -9.5949 | 0.3310 | 0.0793 | 0.1189 | 3.4999 |
| Ixabepilone | Hs 578T | -4.4045 | 0.9537 | -8.6775 | -8.6117 | -8.7153 | 1.3270 | 0.1267 | 0.1267 | 3.5228 |
| Topotecan | AU565 | -3.9626 | 0.9944 | -7.7496 | -7.7184 | -7.7936 | 2.4000 | 0.0780 | 0.0780 | 3.5241 |
| Bortezomib | HCC1569 | -3.7773 | 0.9930 | -7.4233 | -7.4018 | -7.4695 | 2.6110 | 0.0454 | 0.0454 | 3.5433 |
| Ixabepilone | MCF12A | -4.4045 | 0.9854 | -8.0605 | -8.0065 | -8.1636 | 0.8859 | 0.0525 | 0.0530 | 3.5632 |
| Geldanamycin | 184B5 | -4.0000 | 0.9961 | -7.9520 | -7.9176 | -8.0712 | 3.0480 | 0.1082 | 0.1082 | 3.5639 |
| Torkinib | MDA-MB-231 | -4.3010 | 0.9847 | -8.0150 | -7.9267 | -8.1456 | 0.3660 | 0.0358 | 0.0762 | 3.5646 |
| Omipalisib | MDA-MB-361 | -4.4776 | 0.9850 | -7.9296 | -7.9292 | -8.7448 | 0.8961 | 0.0000 | 0.0012 | 3.5825 |
| Omipalisib | MCF 10A | -4.4776 | 0.9921 | -8.0456 | -8.0015 | -8.1389 | 0.6359 | 0.0311 | 0.0362 | 3.5848 |
| Ixabepilone | HCC38 | -4.4045 | 0.9809 | -8.4885 | -8.4450 | -8.5790 | 1.9030 | 0.1118 | 0.1118 | 3.5849 |