Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Imatinib | 184A1 | -3.2480 | 0.9625 | -4.6160 | -4.6155 | -4.8241 | 2.0840 | 0.0000 | 0.0014 | 6.7905 |
| Imatinib | MCF12A | -3.2480 | 0.9668 | -4.4045 | -4.4029 | -4.4579 | 3.4055 | 0.0060 | 0.0065 | 6.9187 |
| Imatinib | MX1 | -3.2480 | 0.9774 | -4.4760 | -4.4755 | -4.6443 | 3.0110 | 0.0000 | 0.0002 | 6.5052 |
| Imatinib | T47DKBLUC | -3.2480 | 0.9797 | -4.5100 | -4.5088 | -4.6622 | 2.9800 | 0.0011 | 0.0013 | 6.6157 |
| Imatinib | 600MPE | -3.2480 | 0.9755 | -4.4640 | -4.4633 | -4.6059 | 3.9995 | 0.0028 | 0.0028 | 6.8482 |
| Imatinib | HCC2185 | -3.2480 | 0.9751 | -4.4870 | -4.4872 | -4.7372 | 3.1400 | 0.0003 | 0.0005 | 6.4589 |
| Imatinib | HCC3153 | -3.2480 | 0.9889 | -4.4020 | -4.4023 | -4.5682 | 3.1980 | 0.0000 | 0.0021 | 6.6772 |
| Imatinib | LY2 | -3.2480 | 0.9694 | -4.5880 | -4.5861 | -4.6676 | 3.9960 | 0.0080 | 0.0080 | 6.7721 |
| Imatinib | ZR75B | -3.2480 | 0.9857 | -4.5050 | -4.5001 | -4.5944 | 3.1900 | 0.0181 | 0.0182 | 6.9600 |
| PD173074 | MCF7 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| PD173074 | SK-BR-3 | -4.4776 | 0.9752 | -4.9176 | -4.9175 | -4.9949 | 1.9200 | 0.0000 | 0.1251 | 7.7539 |
| PD173074 | MDA-MB-231 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.7436 |
| PD173074 | AU565 | -4.4776 | 0.9380 | -5.1283 | -5.0852 | -5.1382 | 3.9970 | 0.1635 | 0.1656 | 8.0550 |
| PD173074 | BT-20 | -4.4776 | 0.8027 | -5.0040 | -4.8614 | -5.1114 | 4.0000 | 0.3654 | 0.3703 | 8.6204 |
| PD173074 | BT-474 | -4.4776 | 0.9345 | -4.8460 | -4.8119 | -4.9537 | 4.0000 | 0.1345 | 0.1627 | 8.3440 |
| PD173074 | BT-483 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| PD173074 | BT-549 | -4.4776 | 0.9379 | -5.0909 | -5.0909 | -5.1028 | 2.5840 | 0.0000 | 0.0254 | 7.9333 |
| PD173074 | CAMA-1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| PD173074 | HCC1143 | -4.4776 | 0.9259 | -4.8148 | -4.7874 | -4.9249 | 1.7550 | 0.0524 | 0.2455 | 8.1306 |
| PD173074 | HCC1395 | -4.4776 | 0.9577 | -5.5896 | -5.5895 | -6.1550 | 0.5878 | 0.0000 | 0.1817 | 6.7448 |
| PD173074 | HCC1419 | -4.4776 | 0.7651 | -4.2805 | -4.4776 | -5.1784 | 1.1525 | 0.0000 | 0.6269 | 8.3843 |
| PD173074 | HCC1428 | -4.4776 | 0.9713 | -5.1368 | -5.1367 | -5.3555 | 2.3020 | 0.0000 | 0.0295 | 7.2858 |
| PD173074 | HCC1569 | -4.4776 | 0.9700 | -5.0968 | -5.0968 | -5.2307 | 2.3460 | 0.0000 | 0.0341 | 7.3805 |
| PD173074 | HCC1806 | -4.4776 | 0.9650 | -5.3356 | -5.3190 | -5.4146 | 2.0860 | 0.0381 | 0.0534 | 6.9584 |
| PD173074 | HCC1937 | -4.4776 | 0.9241 | -5.0937 | -5.0084 | -5.1118 | 3.9980 | 0.2718 | 0.2743 | 8.2801 |