Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1398 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.64 NGFR rabbit IgG(H+L) / donkey NGFR 1025.20
WM115-A2-rep2
A7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1445 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.41 NGFR rabbit IgG(H+L) / donkey NGFR 1020.33
WM115-A2-rep2
A8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1643 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.59 NGFR rabbit IgG(H+L) / donkey NGFR 1021.18
WM115-A2-rep2
A9
WM-115 Vemurafenib Olaparib 1.0000 2.6667
uM
 48
hr
 2 1137 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 140.72 NGFR rabbit IgG(H+L) / donkey NGFR 1028.30
WM115-A2-rep2
B2
WM-115 Vemurafenib Iniparib 1.0000 2.6667
uM
 48
hr
 2 1379 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.25 NGFR rabbit IgG(H+L) / donkey NGFR 992.21
WM115-A2-rep2
B3
WM-115 Vemurafenib CTB 1.0000 2.6667
uM
 48
hr
 2 1474 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 139.13 NGFR rabbit IgG(H+L) / donkey NGFR 836.64
WM115-A2-rep2
B4
WM-115 Vemurafenib Rocilinostat 1.0000 2.6667
uM
 48
hr
 2 1454 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 116.84 NGFR rabbit IgG(H+L) / donkey NGFR 520.46
WM115-A2-rep2
B5
WM-115 Vemurafenib GSK-J1 1.0000 2.6667
uM
 48
hr
 2 1583 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 129.68 NGFR rabbit IgG(H+L) / donkey NGFR 1085.48
WM115-A2-rep2
B6
WM-115 Vemurafenib PFI-1 1.0000 2.6667
uM
 48
hr
 2 1357 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 122.24 NGFR rabbit IgG(H+L) / donkey NGFR 628.79
WM115-A2-rep2
B7
WM-115 Vemurafenib UNC669 1.0000 2.6667
uM
 48
hr
 2 1434 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 128.53 NGFR rabbit IgG(H+L) / donkey NGFR 1073.23
WM115-A2-rep2
B8
WM-115 Vemurafenib Veliparib 1.0000 2.6667
uM
 48
hr
 2 1323 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 147.36 NGFR rabbit IgG(H+L) / donkey NGFR 1068.09
WM115-A2-rep2
C2
WM-115 Vemurafenib Rucaparib 1.0000 2.6667
uM
 48
hr
 2 1442 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.89 NGFR rabbit IgG(H+L) / donkey NGFR 1104.39
WM115-A2-rep2
C3
WM-115 Vemurafenib Belinostat 1.0000 2.6667
uM
 48
hr
 2 690 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 141.25 NGFR rabbit IgG(H+L) / donkey NGFR 284.20
WM115-A2-rep2
C4
WM-115 Vemurafenib Selisistat 1.0000 2.6667
uM
 48
hr
 2 1456 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 148.89 NGFR rabbit IgG(H+L) / donkey NGFR 1101.38
WM115-A2-rep2
C5
WM-115 Vemurafenib GSK-J2 1.0000 2.6667
uM
 48
hr
 2 1641 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 117.71 NGFR rabbit IgG(H+L) / donkey NGFR 1004.18
WM115-A2-rep2
C6
WM-115 Vemurafenib (+)-JQ1 1.0000 2.6667
uM
 48
hr
 2 777 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.60 NGFR rabbit IgG(H+L) / donkey NGFR 527.85
WM115-A2-rep2
C7
WM-115 Vemurafenib UNC1215 1.0000 2.6667
uM
 48
hr
 2 1500 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.65 NGFR rabbit IgG(H+L) / donkey NGFR 1136.36
WM115-A2-rep2
C8
WM-115 Vemurafenib Vorinostat 1.0000 2.6667
uM
 48
hr
 2 1419 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.82 NGFR rabbit IgG(H+L) / donkey NGFR 531.22
WM115-A2-rep2
D2
WM-115 Vemurafenib JW55 1.0000 2.6667
uM
 48
hr
 2 1346 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 130.36 NGFR rabbit IgG(H+L) / donkey NGFR 1010.77
WM115-A2-rep2
D3
WM-115 Vemurafenib Entinostat 1.0000 2.6667
uM
 48
hr
 2 1505 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 119.16 NGFR rabbit IgG(H+L) / donkey NGFR 623.46
WM115-A2-rep2
D4
WM-115 Vemurafenib AGK2 1.0000 2.6667
uM
 48
hr
 2 313 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.37 NGFR rabbit IgG(H+L) / donkey NGFR 888.19
WM115-A2-rep2
D5
WM-115 Vemurafenib GSK-J4 1.0000 2.6667
uM
 48
hr
 2 1545 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 119.21 NGFR rabbit IgG(H+L) / donkey NGFR 1027.05
WM115-A2-rep2
D6
WM-115 Vemurafenib (-)-JQ1 1.0000 2.6667
uM
 48
hr
 2 1586 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 130.37 NGFR rabbit IgG(H+L) / donkey NGFR 1003.69
WM115-A2-rep2
D7
WM-115 Vemurafenib IOX2 1.0000 2.6667
uM
 48
hr
 2 1494 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 128.38 NGFR rabbit IgG(H+L) / donkey NGFR 1004.05
WM115-A2-rep2
D8
WM-115 Vemurafenib Azacitidine 1.0000 2.6667
uM
 48
hr
 2 841 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 149.83 NGFR rabbit IgG(H+L) / donkey NGFR 592.72
WM115-A2-rep2
E2