Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21NT | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14610.189 | uM | 0.28136 | 0.47547 | -0.9402 | -0.9548 | 2.0356 | 0.7876 | 0.9958 | 1.0787 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| CAL-148 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15276.203 | uM | 0.04767 | 0.09858 | -0.8960 | -0.9196 | 1.4362 | 1.0010 | 0.9955 | 1.6831 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| MCF 10F | NM | - | Carboplatin | DNA cross-linker | DNA cross-linker | 9566.011 | uM | 50.05840 | 101.28940 | -0.7823 | -0.8360 | 1.3945 | 0.3717 | 0.9990 | 2.3358 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7871.018 | uM | inf | inf | 0.9011 | 0.9011 | 0.0000 | -0.0407 | -0.0154 | 1.1973 | |
| CAL-148 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15276.203 | uM | 0.04767 | 0.09858 | -0.8960 | -0.9196 | 1.4362 | 1.0010 | 0.9955 | 1.6831 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7487.102 | uM | 1.06250 | 14.53060 | 0.5584 | -1.0000 | 0.4200 | 0.0918 | 0.9670 | 1.5273 | |
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 9566.026 | uM | 528.70890 | 925.43090 | -0.8038 | -0.8874 | 1.8230 | 0.3767 | 0.9064 | 2.1367 | ||
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 7872.017 | uM | inf | inf | 1.0147 | 1.0147 | 0.0000 | 0.0576 | 0.1865 | 1.5155 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7872.016 | uM | 7.35710 | 5.64830 | 0.1459 | 0.2589 | 2.7594 | 0.2512 | 0.8956 | 1.4834 | ||
| MCF 10F | NM | - | Dichloroacetate | PDK | PDK | 13750.176 | uM | inf | inf | 0.8474 | 0.8474 | 0.0000 | 0.0585 | 0.2166 | 1.5387 | |
| MCF 10F | NM | - | Disulfiram | Proteasome | Proteasome | 13750.174 | uM | inf | inf | 0.7281 | 0.7281 | 0.0000 | 0.1301 | 0.5378 | 1.4282 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| CAL-85-1 | TNBC | - | Torkinib | 15280.211 | uM | 0.00057 | 0.00844 | -0.8064 | -0.8633 | 0.3733 | 1.1993 | 0.9944 | 0.8608 | |||
| CAL-85-1 | TNBC | - | Ribavirin | 15280.211 | uM | 104.41110 | 45.7480 | 0.6941 | 0.4856 | 4.2943 | -0.0088 | 0.8805 | 0.8608 | |||
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 9566.121 | uM | 0.64040 | 1.03820 | -0.7383 | -0.7411 | 1.8818 | 0.6289 | 0.9914 | 2.3089 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7871.016 | uM | inf | 34.66260 | 0.8429 | 0.8429 | 4.9988 | -0.0104 | 0.6376 | 1.0272 | ||
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 7487.09 | uM | 0.20420 | 0.24610 | -0.2461 | -0.1722 | 1.5855 | 0.4893 | 0.9936 | 1.5226 | |
| MCF 10F | NM | - | Everolimus | MTOR | MTOR | 12254.164 | uM | 1.64590 | 87.8530 | -0.0725 | -1.0000 | 0.2762 | 0.3434 | 0.8749 | 1.4589 | |
| MCF 10F | NM | - | Fascaplysin | CDK4 | CDK | 7487.084 | uM | 0.27808 | 0.47257 | -0.9814 | -0.9785 | 2.0446 | 0.6770 | 0.9945 | 1.3396 | |
| SUM229PE | TNBC | - | Ribavirin | 15359.211 | uM | inf | inf | 0.9761 | 0.9761 | 0.0000 | -0.0092 | -0.0004 | 1.4356 | |||
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 7537.067 | uM | 15.44060 | 22.47980 | 0.0008 | -0.1830 | 0.8305 | 0.2246 | 0.9827 | 1.9773 |