Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC1428
HR+
Luminal
 Trichostatin A
HDAC
HDAC
7444.065
uM
1.45170
2.67320
 -0.9873 -0.9919 1.7904 1.1581
0.9992
 0.7419
HCC1428
HR+
Luminal
 Vorinostat
HDAC
HDAC
7443.065
uM
35.62970
56.68970
 -0.9861 -0.9845 2.3432 0.8811
0.9992
 0.8818
HCC1428
HR+
Luminal
 Vorinostat
HDAC
HDAC
7442.065
uM
37.32660
57.23520
 -0.9937 -0.9931 2.5592 0.8858
0.9992
 0.7805
CAMA-1
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
5912.091
uM
21.42560
28.67010
 -0.9748 -0.9689 3.6999 0.4290
0.9992
 1.0917
MCF 10A
NM
Basal B
 Omipalisib
PI3K
PI3K
7485.086
uM
0.02196
0.04236
 -0.2162 -0.2393 0.5951 0.6420
0.9992
 3.3609
SUM149PT
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7530.074
uM
0.05589
0.08823
 -0.8823 -0.8633 2.1969 1.0962
0.9992
 2.0964
SUM149PT
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7530.074
uM
0.05589
0.08823
 -0.8823 -0.8633 2.1969 1.0962
0.9992
 2.0964
SUM149PT
TNBC
Basal B
 Purvalanol A
CDK1
CDK
7530.067
uM
12.6640
14.92770
 -0.2602 -0.2629 2.5691 0.2388
0.9992
 2.0748
HCC2185
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7849.011
uM
4.30770
11.64210
 -0.9997 -1.0000 1.1050 0.6329
0.9992
 0.5467
HCC38
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7469.074
uM
0.06193
0.09293
 -0.9586 -0.9333 2.5945 1.1124
0.9992
 1.9843
HCC38
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7469.074
uM
0.06193
0.09293
 -0.9586 -0.9333 2.5945 1.1124
0.9992
 1.9843
HCC1187
TNBC
Basal A
 Cisplatin
DNA cross-linker
DNA cross-linker
7812.017
uM
3.44630
6.68930
 -0.9960 -1.0000 1.6565 0.5582
0.9992
 1.1362
HCC1187
TNBC
Basal A
 Fascaplysin
CDK4
CDK
7432.084
uM
0.01028
0.01685
 -0.9998 -0.9951 2.2156 1.1594
0.9992
 0.8538
SK-BR-3
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
15327.203
uM
0.00180
0.00383
 -0.8066 -0.7982 1.2648 1.3619
0.9992
 0.9247
AU565
HER2amp
Luminal
 Fascaplysin
CDK4
CDK
5901.084
uM
0.08674
0.20069
 -0.9407 -0.9232 1.2470 0.7548
0.9992
 1.7402
SK-BR-3
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
15327.203
uM
0.00180
0.00383
 -0.8066 -0.7982 1.2648 1.3619
0.9992
 0.9247
T47D
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14924.203
uM
0.00405
0.00616
 -0.9568 -0.9655 2.5587 1.4202
0.9993
 1.0024
MDA-MB-157
TNBC
Basal B
 Bromopyruvic acid
Hexokinase II
Metabolism
12632.177
uM
0.04978
0.0620
 -0.9999 -0.9991 5.0000 0.9410
0.9993
 0.6753
T47DKBLUC
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14849.203
uM
0.01686
0.02097
 -0.9900 -0.9877 5.0000 1.2349
0.9993
 0.7976
MCF7
HR+
Luminal
 Omipalisib
PI3K
PI3K
7493.086
uM
0.00717
0.01731
 -0.7558 -0.7434 1.0346 1.0210
0.9993
 0.8986
T47D
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14924.203
uM
0.00405
0.00616
 -0.9568 -0.9655 2.5587 1.4202
0.9993
 1.0024
HCC1937
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
7453.074
uM
0.04111
0.05492
 -0.9374 -0.9189 3.6010 1.1822
0.9993
 1.5871
T47DKBLUC
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14849.203
uM
0.01686
0.02097
 -0.9900 -0.9877 5.0000 1.2349
0.9993
 0.7976
SUM1315MO2
TNBC
Basal B
 MG-132
Proteasome
Proteasome
12428.17
uM
0.12477
0.22218
 -0.9639 -0.9614 1.8587 0.8733
0.9993
 0.9724
SUM185PE
TNBC
Luminal
 LBH589
HDAC
HDAC
12269.154
uM
0.07923
0.19201
 -0.9328 -0.9155 1.1756 0.7622
0.9993
 0.9999