Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300
HCC38
TNBC
Basal B
 Gemcitabine
DNA replication
DNA replication
9028.075
uM
0.00457
0.00564
 -0.9576 -0.9350 5.0000 1.7932
0.9991
 0.6011
HCC70
TNBC
Basal A
 Taxol
TUBB
TUBB
12714.002
uM
0.00853
0.01048
 -0.9148 -0.9050 5.0000 1.1860
0.9991
 0.4328
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300
MDA-MB-157
TNBC
Basal B
 MG-132
Proteasome
Proteasome
12594.17
uM
0.16250
0.26807
 -0.9603 -0.9657 2.1485 0.8363
0.9991
 1.2180
MCF 10A
NM
Basal B
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7483.067
uM
7.35150
12.33760
 -0.7295 -0.7449 1.7619 0.3474
0.9991
 3.2893
HCC1937
TNBC
Basal A
 Fascaplysin
CDK4
CDK
7452.084
uM
0.36891
0.53806
 -0.9076 -0.8914 2.7117 0.6139
0.9991
 1.6800
HCC70
TNBC
Basal A
 LBH589
HDAC
HDAC
12400.167
uM
0.06833
0.10488
 -0.9417 -0.9461 2.4791 0.8654
0.9991
 1.2627
HCC1937
TNBC
Basal A
 MG-132
Proteasome
Proteasome
11849.145
uM
0.13365
0.16967
 -0.8677 -0.8553 4.1787 0.8372
0.9991
 1.5253
MDA-MB-361
HER2amp
Luminal
 17-AAG
HSP90
HSP90
9648.037
uM
0.03015
0.0370
 -0.9033 -0.8903 5.0000 1.1329
0.9991
 0.6971
HCC1937
TNBC
Basal A
 MG-132
Proteasome
Proteasome
11849.145
uM
0.13365
0.16967
 -0.8677 -0.8553 4.1787 0.8372
0.9991
 1.5253
HCC3153
TNBC
Basal A
 NSC 663284
CDC25
CDC
10577.14
uM
2.4650
3.61860
 -0.9817 -0.9832 2.8326 0.5933
0.9991
 0.9722
HCC70
TNBC
Basal A
 Carboplatin
DNA cross-linker
DNA cross-linker
7860.011
uM
17.88260
22.44810
 -0.9954 -0.9945 4.8154 0.6186
0.9991
 0.7135
SK-BR-3
HER2amp
Luminal
 Taxol
TUBB
TUBB
12999.002
uM
0.01340
0.01801
 -0.6045 -0.5861 2.6195 0.9107
0.9991
 0.8869
Hs 578T
TNBC
Basal B
 Bromopyruvic acid
Hexokinase II
Metabolism
12622.177
uM
0.23724
0.28366
 -0.7666 -0.7219 5.0000 0.6272
0.9991
 2.5433
HCC1143
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
14829.203
uM
0.00363
0.01223
 -0.9240 -0.9232 0.8622 1.2815
0.9991
 1.2743
MDA-MB-361
HER2amp
Luminal
 Torkinib
15396.211
uM
0.00334
0.01326
 -0.6071 -0.6008 0.5726 1.0084
0.9991
 0.9137
SUM159PT
TNBC
Basal B
 Geldanamycin
HSP90
HSP90
7919.04
uM
0.00594
0.00689
 -0.2375 -0.2460 2.7121 0.9268
0.9992
 3.7375
AU565
HER2amp
Luminal
 NSC 663284
CDC25
CDC
10880.152
uM
1.58810
2.95150
 -0.9114 -0.9095 1.6722 0.5940
0.9992
 1.5019
HCC70
TNBC
Basal A
 Taxol
TUBB
TUBB
9501.002
uM
0.00722
0.01212
 -0.6813 -0.6365 1.5836 1.0061
0.9992
 1.0082
AU565
HER2amp
Luminal
 TCS 2312
CHK1
CHK
10880.152
uM
0.28434
0.39562
 -0.9128 -0.9095 3.1379 0.6283
0.9992
 1.5019
AU565
HER2amp
Luminal
 Vorinostat
HDAC
HDAC
5900.065
uM
97.10380
150.36460
 -0.8266 -0.8361 2.2478 0.6955
0.9992
 2.2026
HCC1428
HR+
Luminal
 Fascaplysin
CDK4
CDK
7444.084
uM
0.02965
0.04679
 -0.9954 -0.9959 2.4028 1.0317
0.9992
 0.8647
HCC1806
TNBC
Basal A
 Sigma A6730
AKT
AKT
12239.165
uM
9.67380
17.26610
 -0.8465 -0.9909 1.8858 0.2211
0.9992
 2.0705
HBL-100
Unknown
Unknown
 Gemcitabine
DNA replication
DNA replication
7807.011
uM
0.02882
0.03612
 -0.4577 -0.4250 2.7264 0.9196
0.9992
 2.1620