Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 12594.17 | uM | 0.16250 | 0.26807 | -0.9603 | -0.9657 | 2.1485 | 0.8363 | 0.9991 | 1.2180 | |
| SUM225CWN | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7534.065 | uM | 10.50870 | 15.19020 | -0.9528 | -0.9489 | 2.8877 | 0.8542 | 0.9991 | 0.9529 | |
| HBL-100 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7429.084 | uM | 48.25460 | 66.54960 | -0.7786 | -0.7812 | 2.9272 | 0.3710 | 0.9991 | 2.2510 | |
| SUM229PE | TNBC | - | Methylglyoxal | 13201.184 | uM | 535.45630 | 662.02810 | -0.9518 | -0.9445 | 4.9999 | 0.6502 | 0.9991 | 1.3314 | |||
| HCC1143 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14829.203 | uM | 0.00363 | 0.01223 | -0.9240 | -0.9232 | 0.8622 | 1.2815 | 0.9991 | 1.2743 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 7537.084 | uM | 0.40339 | 0.56565 | -0.8695 | -0.8666 | 2.9742 | 0.5868 | 0.9991 | 1.8684 | |
| HCC3153 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7467.084 | uM | 0.14128 | 0.23345 | -0.9722 | -0.9668 | 2.1428 | 0.7710 | 0.9991 | 1.3029 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 13009.177 | uM | 0.02778 | 0.03439 | -0.9703 | -0.9534 | 5.0000 | 1.0656 | 0.9991 | 1.2366 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9278.037 | uM | 0.02447 | 0.03619 | -0.9993 | -0.9737 | 2.7625 | 1.1989 | 0.9991 | 0.3822 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 10695.154 | uM | 0.26148 | 0.34978 | -0.8474 | -0.8430 | 3.3962 | 0.6504 | 0.9991 | 1.4756 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10939.145 | uM | 0.11495 | 0.15659 | -0.8571 | -0.8473 | 3.2066 | 0.8684 | 0.9991 | 1.6558 | |
| HCC70 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7857.017 | uM | 1.60450 | 2.36240 | -0.9732 | -0.9789 | 2.8032 | 0.7284 | 0.9991 | 1.1840 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7920.075 | uM | 70.40610 | 84.95560 | -0.2887 | -0.2931 | 2.4562 | 0.2851 | 0.9991 | 4.5785 | |
| SK-BR-3 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9759.011 | uM | 2.11420 | 6.14970 | -0.9000 | -0.9121 | 0.9724 | 0.6810 | 0.9991 | 1.2153 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 7849.04 | uM | 0.01717 | 0.02311 | -0.8205 | -0.7965 | 3.2059 | 1.1738 | 0.9991 | 0.5448 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7793.007 | uM | 0.00691 | 0.01211 | -0.7351 | -0.7087 | 1.5714 | 1.2066 | 0.9991 | 1.3832 | |
| HCC1143 | TNBC | Basal A | IKK16 | IKK | NFKB | 7430.093 | uM | 3.9730 | 4.84760 | -0.8497 | -0.8522 | 5.0000 | 0.3517 | 0.9991 | 1.9432 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5901.065 | uM | 3.0340 | 4.48290 | -0.8445 | -0.8088 | 2.4647 | 0.9833 | 0.9991 | 2.0114 | |
| HCC70 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7857.011 | uM | 12.96930 | 16.26290 | -0.9756 | -0.9722 | 4.7718 | 0.6272 | 0.9991 | 1.0477 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 10694.147 | uM | 1.63690 | 3.29360 | -0.6479 | -0.6730 | 1.2196 | 0.3912 | 0.9991 | 2.3818 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7443.065 | uM | 1.70780 | 2.75150 | -0.9769 | -0.9745 | 2.2675 | 1.1356 | 0.9991 | 0.8818 | |
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7512.084 | uM | 0.05608 | 0.07520 | -0.9999 | -0.9952 | 3.7340 | 0.9064 | 0.9991 | 0.7511 | |
| 184B5 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 9095.049 | uM | 0.00859 | 0.01158 | -0.7576 | -0.7255 | 2.9985 | 1.2019 | 0.9991 | 1.1202 |