Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| HCC1954 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7456.084 | uM | 0.31254 | 0.47190 | -0.8694 | -0.8430 | 2.3979 | 0.6118 | 0.9984 | 1.9822 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12400.17 | uM | 0.07474 | 0.11640 | -0.9170 | -0.9300 | 2.3720 | 0.9712 | 0.9984 | 1.1992 | |
| HCC3153 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10577.14 | uM | 0.51320 | 0.79217 | -0.8743 | -0.8700 | 2.3219 | 0.5520 | 0.9984 | 0.9722 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9146.002 | uM | 0.00498 | 0.00636 | -0.6733 | -0.6767 | 3.4844 | 0.9399 | 0.9984 | 1.2611 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7498.074 | uM | 0.02939 | 0.04654 | -0.9813 | -0.9617 | 2.3346 | 1.2452 | 0.9984 | 1.0877 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9760.131 | uM | 2.20840 | 3.62970 | -0.9282 | -0.9079 | 2.0834 | 0.6047 | 0.9984 | 0.9878 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7498.074 | uM | 0.02939 | 0.04654 | -0.9813 | -0.9617 | 2.3346 | 1.2452 | 0.9984 | 1.0877 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 9244.002 | uM | 0.00722 | 0.00898 | -0.9968 | -0.9950 | 5.0000 | 1.2989 | 0.9984 | 0.5206 | |
| HMT-3522 T4-2 | Unknown | Unknown | Taxol | TUBB | TUBB | 10147.002 | uM | 0.00858 | 0.00955 | -0.3666 | -0.3520 | 4.9998 | 0.8604 | 0.9984 | 1.9641 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7469.074 | uM | 0.38626 | 0.67303 | -0.5694 | -0.5634 | 1.3590 | 0.7416 | 0.9984 | 1.9843 | |
| HCC1937 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7453.065 | uM | 195.40680 | 353.64710 | -0.3863 | -0.4217 | 1.0310 | 0.4348 | 0.9984 | 1.6649 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5901.091 | uM | 19.04840 | 28.45990 | -0.8741 | -0.8850 | 2.5375 | 0.4460 | 0.9984 | 1.9229 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 7485.065 | uM | 28.32790 | 56.52840 | -0.4782 | -0.4940 | 0.9945 | 0.5158 | 0.9984 | 3.5869 | |
| SUM52PE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10695.152 | uM | 2.59830 | 4.10010 | -0.9330 | -0.9389 | 2.3173 | 0.5662 | 0.9985 | 1.2495 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5894.095 | uM | 0.46640 | 0.69919 | -0.9010 | -0.8976 | 2.5388 | 0.6159 | 0.9985 | 1.7133 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10150.012 | uM | 0.02042 | 0.02445 | -0.7512 | -0.7308 | 4.9997 | 1.1335 | 0.9985 | 0.4611 | |
| MCF12A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7489.09 | uM | 31.0410 | 41.980 | -0.8584 | -0.8585 | 3.3109 | 0.3463 | 0.9985 | 1.9790 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14284.189 | uM | 0.36137 | 0.67697 | -0.9692 | -0.9604 | 1.7075 | 0.7034 | 0.9985 | 1.3873 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 7485.092 | uM | 2.71020 | 1.84470 | 0.2084 | 0.1437 | 0.8807 | 0.2027 | 0.9985 | 3.6408 | |
| SUM149PT | TNBC | Basal B | IKK16 | IKK | NFKB | 7530.093 | uM | 1.87280 | 3.05350 | -0.7995 | -0.8199 | 1.9856 | 0.4273 | 0.9985 | 2.1548 | |
| MDA-MB-231 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7504.074 | uM | 0.09433 | 0.12339 | -0.8488 | -0.8128 | 3.5944 | 0.9992 | 0.9985 | 1.8962 | |
| SUM149PT | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 10819.147 | uM | 7.07230 | 8.84820 | -0.7606 | -0.7610 | 4.1293 | 0.3660 | 0.9985 | 2.1652 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7821.017 | uM | 0.78388 | 0.97271 | -1.0000 | -0.9710 | 5.0000 | 0.7996 | 0.9985 | 0.3792 |