Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5911.094 | uM | 0.00116 | 0.00147 | -0.9872 | -0.4078 | 2.5090 | 1.3193 | 0.6376 | 1.0146 | |
| ZR75B | HR+ | Luminal | Torkinib | 15405.211 | uM | 0.00030 | 0.00154 | -0.3164 | -0.3506 | 0.3246 | 0.9816 | 0.9922 | 1.5333 | |||
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7808.002 | uM | 0.00194 | 0.00155 | 0.3152 | 0.1983 | 2.2864 | 0.5513 | 0.9438 | 2.3302 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7900.012 | uM | 0.00157 | 0.00156 | -0.2721 | 0.0157 | 5.0000 | 0.8700 | 0.6184 | 0.8090 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7845.068 | uM | 0.00087 | 0.00157 | -0.5451 | -0.3982 | 0.9850 | 1.2168 | 0.9289 | 0.3849 | |
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 13004.002 | uM | 0.00146 | 0.00162 | -0.0693 | -0.0843 | 1.4851 | 0.7365 | 0.9961 | 3.1387 | |
| HCC1569 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 9347.002 | uM | inf | 0.00163 | 0.5098 | 0.5087 | 1.2928 | 0.3277 | 0.9210 | 1.4904 | |
| 184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 9047.002 | uM | 0.00721 | 0.00164 | 0.3271 | 0.2689 | 0.5211 | 0.4844 | 0.7111 | 0.5243 | |
| MCF 10A | NM | Basal B | Dichloroacetate | PDK | PDK | 12944.176 | uM | inf | 0.00165 | 0.9070 | 0.9353 | 1.3443 | 0.0350 | 0.7319 | 2.5862 | |
| SUM225CWN | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7533.069 | uM | 0.00404 | 0.00166 | 0.2934 | 0.3132 | 1.1071 | 0.5248 | 0.9943 | 1.1713 | |
| BT-474 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5906.095 | uM | 0.00127 | 0.00167 | -0.9990 | -0.3324 | 1.8966 | 0.9953 | 0.6890 | 0.6731 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1806 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12702.002 | uM | 0.00118 | 0.00171 | -0.4526 | -0.4961 | 1.8445 | 1.0089 | 0.9954 | 1.8712 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7816.001 | uM | 0.00151 | 0.00173 | -0.9805 | -0.4672 | 4.9998 | 1.1061 | 0.9094 | 1.0243 | |
| SUM52PE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9889.002 | uM | 0.00130 | 0.00174 | -0.3619 | -0.3400 | 1.7739 | 0.9146 | 0.9936 | 1.1879 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7894.001 | uM | 0.00171 | 0.00176 | -0.2941 | -0.0655 | 5.0000 | 0.8182 | 0.9150 | 0.7678 | |
| SK-BR-3 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9760.026 | uM | inf | 0.00176 | 0.5020 | 0.5240 | 4.9999 | 0.3121 | 0.9733 | 1.0724 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9469.121 | uM | 0.00096 | 0.00177 | -0.7010 | -0.7334 | 1.4902 | 1.4796 | 0.9951 | 1.1298 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7807.002 | uM | 0.00197 | 0.00179 | 0.2403 | 0.1261 | 3.1066 | 0.6084 | 0.9293 | 2.1668 | |
| SUM149PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9830.002 | uM | 0.00179 | 0.00180 | -0.0390 | -0.0047 | 2.1102 | 0.6781 | 0.950 | 1.9252 | |
| HCC1569 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 7447.102 | uM | inf | 0.00181 | 0.7277 | 0.8106 | 1.1886 | 0.1183 | 0.8186 | 1.6467 | |
| AU565 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9146.122 | uM | inf | 0.00184 | 0.5003 | 0.6442 | 5.0000 | 0.2137 | 0.8848 | 1.3408 | |
| MDA-MB-175-VII | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7500.069 | uM | 0.00293 | 0.00185 | 0.3935 | 0.4499 | 4.9999 | 0.4145 | 0.9762 | 0.7701 | |
| HCC1569 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7447.068 | uM | 0.01777 | 0.00189 | 0.2985 | 0.3535 | 0.5478 | 0.5385 | 0.9617 | 1.5836 |