Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9723.121 | uM | 0.22157 | 0.32961 | -0.9910 | -0.9066 | 2.6041 | 0.8287 | 0.9948 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 9723.121 | uM | 0.06218 | 0.23448 | -0.7987 | -0.8193 | 0.7310 | 0.8811 | 0.9748 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9723.121 | uM | 6.76050 | 19.06660 | -0.5324 | -0.8802 | 0.9793 | 0.2210 | 0.9918 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 9723.124 | uM | inf | 0.07331 | 0.4338 | 0.5359 | 3.4322 | 0.3131 | 0.9350 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | Trastuzumab | HER2 | ErbB | 9723.124 | uM | inf | 0.00115 | 0.4864 | 0.6553 | 4.9994 | 0.2269 | 0.8119 | 0.9827 | |
| MDA-MB-453 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 9723.124 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0369 | -1.9688 | 0.9827 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9759.001 | uM | 0.01929 | 0.02068 | 0.0763 | -0.1889 | 4.6086 | 0.6864 | 0.8737 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9759.001 | uM | 8.13140 | 8.17820 | -0.0136 | -0.0145 | 4.9937 | 0.0854 | 0.9779 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9759.001 | uM | 0.03930 | 0.04866 | -0.4805 | -0.5014 | 3.2511 | 0.7650 | 0.9925 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9759.002 | uM | 0.01110 | 0.01416 | -0.6775 | -0.6538 | 3.4304 | 0.9680 | 0.9984 | 1.1336 | |
| SK-BR-3 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9759.002 | uM | 0.00759 | 0.01165 | -0.7027 | -0.6563 | 1.9568 | 0.8786 | 0.9963 | 1.1336 | |
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9759.006 | uM | inf | inf | 0.5724 | 0.5724 | 0.0000 | 0.2506 | 0.4359 | 1.2714 | ||
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9759.006 | uM | inf | inf | 0.9596 | 0.9596 | 0.0000 | 0.0960 | 0.0987 | 1.2714 | |
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9759.006 | uM | 0.01154 | 0.01323 | -0.9273 | -0.4937 | 4.9999 | 1.1745 | 0.8807 | 1.2714 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9759.011 | uM | 0.01008 | 0.01118 | -0.4098 | -0.3361 | 5.0000 | 0.9634 | 0.9873 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9759.011 | uM | 9.95620 | 20.98690 | -0.8893 | -0.8616 | 1.3435 | 0.6033 | 0.9950 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9759.011 | uM | 2.11420 | 6.14970 | -0.9000 | -0.9121 | 0.9724 | 0.6810 | 0.9991 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9759.012 | uM | 0.0130 | 0.01442 | -0.1909 | -0.0740 | 1.3326 | 0.7299 | 0.9855 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9759.012 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | -0.0132 | -0.0794 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 9759.019 | uM | 2.22660 | 1.73360 | 0.1080 | 0.3570 | 5.0000 | 0.2242 | 0.6620 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9759.019 | uM | 43.44110 | 92.81930 | -0.4154 | -1.0000 | 1.4470 | 0.1702 | 0.9813 | 1.3677 | ||
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9759.019 | uM | 2.73010 | 5.45130 | -0.2468 | -0.4718 | 0.9610 | 0.2580 | 0.9868 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9759.037 | uM | 0.04238 | 0.11134 | -0.6105 | -0.3754 | 0.5798 | 0.6842 | 0.9183 | 1.2944 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9759.121 | uM | 0.01180 | 0.03028 | -0.8569 | -0.7685 | 0.9880 | 1.1074 | 0.9933 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9759.121 | uM | 1.39990 | 3.73010 | -0.6968 | -0.7750 | 0.9552 | 0.4445 | 0.9894 | 1.2887 |