Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 7429.084 | uM | 0.51395 | 0.68198 | -0.7688 | -0.7596 | 3.2661 | 0.5289 | 0.9995 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 9226.012 | uM | 0.02301 | 0.02808 | -0.3154 | -0.1486 | 1.3062 | 0.7103 | 0.9670 | 2.5039 | |
| HBL-100 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 7807.04 | uM | 0.03553 | 0.04820 | -0.3708 | -0.2711 | 1.4204 | 0.7397 | 0.9883 | 2.1435 | |
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 7807.011 | uM | 0.02882 | 0.03612 | -0.4577 | -0.4250 | 2.7264 | 0.9196 | 0.9992 | 2.1620 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 7808.001 | uM | 0.19841 | 1.24310 | -0.9041 | -1.0000 | 0.5987 | 0.5723 | 0.9550 | 2.5321 | |
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7807.04 | uM | 1.67060 | 4.14870 | -0.7759 | -0.7682 | 1.0232 | 0.4211 | 0.9891 | 2.1435 | |
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7807.016 | uM | 11.62140 | 15.50560 | -0.8212 | -0.8219 | 3.3715 | 0.3669 | 0.9974 | 2.1516 | ||
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7808.016 | uM | inf | 13.19490 | 0.5274 | 0.7135 | 4.9687 | 0.0363 | 0.6432 | 2.2401 | ||
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7808.05 | uM | 0.95232 | 1.51340 | -0.4445 | -0.4552 | 1.3976 | 0.4994 | 0.9942 | 2.5177 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7808.017 | uM | 153.52750 | 267.86840 | -0.0890 | -0.1730 | 0.5339 | 0.3993 | 0.9832 | 2.4168 | |
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 7429.066 | uM | inf | inf | 0.9919 | 0.9919 | 0.0000 | 0.0080 | 0.0137 | 2.3904 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7808.016 | uM | inf | inf | 0.9515 | 0.9515 | 0.0000 | -0.0168 | 0.0597 | 2.2401 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7808.011 | uM | 91.64120 | 178.22410 | -0.9131 | -0.9831 | 1.6346 | 0.3085 | 0.9967 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7807.011 | uM | 80.29730 | 142.76360 | -0.7730 | -0.8163 | 1.6820 | 0.3238 | 0.9983 | 2.1620 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7807.042 | uM | inf | inf | 1.0098 | 1.0098 | 0.0000 | -0.0392 | -7.7987 | 2.0250 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 7808.052 | uM | inf | 0.72086 | 0.5882 | 0.6283 | 0.8496 | 0.1837 | 0.9560 | 2.4842 | ||
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7807.017 | uM | inf | inf | -0.4695 | -0.4695 | 0.0000 | 0.2218 | 0.4545 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 9226.021 | uM | 8.73650 | 13.53040 | -0.6894 | -0.7018 | 2.0049 | 0.3883 | 0.9995 | 2.5142 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 7808.043 | uM | 3.95580 | 3.81630 | -0.1647 | 0.0821 | 5.0000 | 0.2428 | 0.8707 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 7808.043 | uM | 0.03423 | 0.04488 | -0.2801 | -0.5530 | 2.7489 | 0.9385 | 0.9153 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 9226.034 | uM | 0.06059 | 0.09525 | -0.8190 | -0.7193 | 1.9706 | 0.9033 | 0.9973 | 2.6175 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 7429.084 | uM | inf | 0.12857 | 0.6858 | 0.7716 | 5.0000 | 0.1377 | 0.8694 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 7429.067 | uM | 0.02923 | 0.03665 | -0.8592 | -0.4894 | 3.0166 | 0.7627 | 0.9592 | 2.2169 |