Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7909.016 | uM | 108.46670 | 254.11780 | 0.2570 | -1.0000 | 1.2904 | 0.1317 | 0.6828 | 1.3701 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9536.019 | uM | 52.79420 | 96.35390 | -0.4711 | -1.0000 | 1.8261 | 0.2015 | 0.9497 | 1.5595 | ||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10755.15 | uM | inf | inf | 0.4395 | 0.4395 | 0.0000 | 0.2504 | 0.3664 | 0.7807 | ||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10473.138 | uM | inf | 1.19780 | 0.7189 | 0.7475 | 4.9965 | 0.0394 | 0.9219 | 1.2872 | ||
| SUM159PT | TNBC | Basal B | Ribavirin | 15402.211 | uM | 51.66870 | 999.82030 | 0.4628 | -0.6950 | 0.2941 | 0.1569 | 0.8782 | 3.0887 | |||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12070.16 | uM | 1.30120 | 1.15090 | 0.2168 | 0.2294 | 4.9999 | 0.2666 | 0.9242 | 0.8453 | ||
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7830.016 | uM | inf | inf | 0.2581 | 0.2581 | 0.0000 | 0.1910 | 0.3538 | 2.0313 | ||
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7829.016 | uM | 13.43190 | 18.22980 | -0.8442 | -0.8456 | 3.2414 | 0.3225 | 0.9995 | 1.9532 | ||
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7907.016 | uM | inf | inf | 0.5786 | 0.5786 | 0.0000 | 0.1202 | 0.4906 | 1.3145 | ||
| HCC1806 | TNBC | Basal A | 2-deoxyglucose | 12702.177 | uM | 556.93120 | 1000.00000 | -0.1052 | -0.4162 | 1.0348 | 0.1905 | 0.9832 | 1.5730 | |||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10873.15 | uM | 0.92080 | 0.83559 | 0.0558 | 0.0929 | 2.1170 | 0.2468 | 0.9894 | 1.1958 | ||
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7906.016 | uM | inf | inf | -0.6451 | -0.6451 | 0.0000 | 0.5855 | 0.2634 | 0.8028 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7854.016 | uM | inf | 7.23080 | 0.3700 | 0.5045 | 5.0000 | 0.1340 | 0.8222 | 0.9074 | ||
| HCC70 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7856.016 | uM | inf | 11.83740 | 0.7410 | 0.6982 | 0.6309 | 0.0644 | 0.8127 | 0.9156 | ||
| SK-BR-3 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 11851.16 | uM | 48.29610 | 344.4820 | 0.4174 | -1.0000 | 0.5592 | 0.1148 | 0.9623 | 1.1668 | ||
| SUM159PT | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7531.096 | uM | inf | inf | 0.8694 | 0.8694 | 0.0000 | 0.0391 | 0.3982 | 3.5504 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7875.018 | uM | 123.00360 | 811.46460 | -0.6784 | -1.0000 | 0.5823 | 0.3989 | 0.9523 | 1.6565 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10073.034 | uM | 869.1580 | 1000.00000 | -0.8708 | -0.5080 | 5.0000 | 0.1985 | 0.7391 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7874.018 | uM | 89.31090 | 1000.00000 | -0.5749 | -0.8076 | 0.3980 | 0.3580 | 0.6990 | 1.6506 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12400.169 | uM | 0.69220 | 0.70339 | -0.0677 | -0.0418 | 5.0000 | 0.4240 | 0.9528 | 1.2449 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9583.026 | uM | 321.32760 | 1000.00000 | -0.2230 | -0.3704 | 0.4883 | 0.2592 | 0.7368 | 1.2731 | ||
| 600MPE | HR+ | Luminal | Mebendazole | 13091.174 | uM | 14.64610 | 480.70650 | 0.3243 | -1.0000 | 0.3147 | 0.2245 | 0.8786 | 0.7967 | |||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 12254.16 | uM | inf | inf | 0.8887 | 0.8887 | 0.0000 | -0.0374 | 0.1921 | 1.4029 | ||
| CAMA-1 | HR+ | Luminal | Ibandronate | FDPS | 12070.143 | uM | 209.3390 | 252.68780 | -0.7810 | -0.7813 | 5.0000 | 0.2384 | 0.9969 | 0.9561 | ||
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7836.016 | uM | 33.93490 | 143.9580 | -0.0804 | -1.0000 | 0.7602 | 0.1638 | 0.9872 | 1.5669 |