Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7441.084 | 0.0111 | -0.9904 | 0.8431 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11851.154 | 0.0111 | -0.9563 | 1.1765 | |
| T47D | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 10939.152 | 0.0111 | -0.8597 | 1.6952 | |
| HCC1954 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 167 | uM | 11055.152 | 0.0111 | -0.8660 | 1.6647 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.533 | uM | 15340.203 | 0.0111 | -0.9110 | 1.4449 | |
| HCC1428 | HR+ | Luminal | IKK16 | IKK | NFKB | 13.3 | uM | 10441.093 | 0.0111 | -0.9605 | 1.1458 | |
| HCC1143 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 133 | uM | 7430.091 | 0.0111 | -0.8432 | 1.7667 | |
| HCC1954 | HER2amp | Basal A | IKK16 | IKK | NFKB | 66.7 | uM | 7455.093 | 0.0111 | -0.8527 | 1.7255 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9536.017 | 0.0112 | -0.9093 | 1.4526 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7553.091 | 0.0112 | -0.9802 | 0.9738 | |
| 600MPE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 12224.165 | 0.0112 | -0.9804 | 0.9714 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14257.189 | 0.0112 | -1.0000 | 0.3775 | |
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 13.3 | uM | 7545.1 | 0.0112 | -0.9613 | 1.1396 | |
| HCC70 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 34.5 | uM | 7857.017 | 0.0112 | -0.9551 | 1.1840 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10472.087 | 0.0112 | -0.9994 | 0.5566 | |
| MCF 10A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7868.05 | 0.0112 | -0.7725 | 2.0672 | |
| SUM185PE | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 7532.091 | 0.0112 | -0.9830 | 0.9414 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7471.065 | 0.0112 | -0.7225 | 2.2733 | |
| HCC1395 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7436.067 | 0.0112 | -0.9396 | 1.2834 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7492.084 | 0.0112 | -0.9028 | 1.4850 | |
| HCC1419 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12001.147 | 0.0112 | -0.9989 | 0.5989 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14257.189 | 0.0112 | -1.0000 | 0.3775 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13038.177 | 0.0112 | -0.9851 | 0.9161 | |
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 7466.074 | 0.0112 | -0.9803 | 0.9724 | |
| BT-474 | HER2amp | Luminal | Chloroquine | 66.5 | uM | 13125.177 | 0.0112 | -0.9865 | 0.8991 |