Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 9511.034 | 0.0121 | -0.9614 | 1.1177 | ||
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7467.074 | 0.0073 | -0.9614 | 1.2457 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 33.3 | uM | 7911.001 | 0.0088 | -0.9614 | 1.2005 | |
| 184B5 | NM | Basal | Ixabepilone | TUBB | TUBB | 7.89 | uM | 5897.095 | 0.0081 | -0.9614 | 1.2197 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 0.267 | uM | 7905.002 | 0.1908 | -0.9614 | 0.4198 | |
| MDA-MB-231 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 39.4 | uM | 7504.095 | 0.0003 | -0.9613 | 2.0796 | |
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 13.3 | uM | 7545.1 | 0.0112 | -0.9613 | 1.1396 | |
| HCC1395 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 333 | uM | 7436.085 | 0.0069 | -0.9613 | 1.2621 | |
| LY2 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 9536.017 | 0.0033 | -0.9612 | 1.4526 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 66.7 | uM | 12428.17 | 0.0217 | -0.9611 | 0.9724 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 66.7 | uM | 12428.17 | 0.0217 | -0.9611 | 0.9724 | |
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14906.203 | 0.0461 | -0.9610 | 0.7818 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 5899.07 | 0.0306 | -0.9610 | 0.8850 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7903.016 | 0.0122 | -0.9610 | 1.1196 | ||
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7896.007 | 0.0122 | -0.9610 | 1.1203 | |
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14906.203 | 0.0461 | -0.9610 | 0.7818 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 66.7 | uM | 12509.164 | 0.0090 | -0.9610 | 1.1949 | |
| MDA-MB-361 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7506.085 | 0.0133 | -0.9609 | 1.0985 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7470.065 | 0.0187 | -0.9607 | 1.0127 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12001.165 | 0.1206 | -0.9607 | 0.5382 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7435.065 | 0.0353 | -0.9606 | 0.8513 | |
| HCC1428 | HR+ | Luminal | IKK16 | IKK | NFKB | 13.3 | uM | 10441.093 | 0.0111 | -0.9605 | 1.1458 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7500.065 | 0.0400 | -0.9605 | 0.8201 | |
| HCC202 | HER2amp | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7458.074 | 0.1972 | -0.9605 | 0.4138 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 46.4 | uM | 7854.018 | 0.0080 | -0.9604 | 1.2298 |