Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0000853 | uM | 7820.002 | 1.1074 | 1.3099 | 0.7084 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7875.001 | 1.1073 | 1.1446 | 1.4600 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9997.024 | 1.1073 | 1.2216 | 0.9704 | |
| SUM229PE | TNBC | - | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9860.012 | 1.1073 | 1.1225 | 1.7144 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7432.065 | 1.1073 | 1.2723 | 0.7981 | |
| BT-549 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 40 | uM | 5910.084 | 1.1073 | 1.0666 | 3.1096 | |
| HCC1806 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7450.067 | 1.1073 | 1.0930 | 2.2419 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9708.001 | 1.1072 | 1.2112 | 1.0142 | |
| BT-483 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.000461 | uM | 9186.026 | 1.1072 | 1.4413 | 0.5108 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 5900.092 | 1.1072 | 1.0789 | 2.6334 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10019.001 | 1.1071 | 1.5847 | 0.3968 | |
| MDA-MB-175-VII | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7886.007 | 1.1071 | 1.3333 | 0.6601 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7821.017 | 1.1071 | 1.6157 | 0.3792 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10267.001 | 1.1071 | 1.5864 | 0.3957 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7431.065 | 1.1071 | 1.1439 | 1.4650 | |
| MDA-MB-468 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 7905.016 | 1.1070 | 1.3538 | 0.6240 | |
| MCF 10F | NM | - | TCS PIM-1 1 | Pim kinase | PIM | 1.07 | uM | 12254.135 | 1.1070 | 1.1260 | 1.6637 | |
| 184A1 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5895.067 | 1.1070 | 1.1500 | 1.4053 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10754.146 | 1.1069 | 1.1696 | 1.2483 | |
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7878.016 | 1.1069 | 1.1488 | 1.4153 | ||
| SUM185PE | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 10146.037 | 1.1069 | 1.3044 | 0.7169 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12178.154 | 1.1069 | 1.4343 | 0.5170 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9511.001 | 1.1068 | 1.1812 | 1.1698 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7812.017 | 1.1068 | 1.1869 | 1.1362 | |
| SUM185PE | TNBC | Luminal | Taxol | TUBB | TUBB | 0.0000853 | uM | 10146.002 | 1.1068 | 1.2218 | 0.9649 |