LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 658 | 25 | 3846 | 0.0065 | -0.1986 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 658 | 35 | 3846 | 0.0091 | -0.1955 |
| Hs 578T | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 658 | 53 | 3846 | 0.0140 | -0.1896 |
| MCF 10A | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 962 | 57 | 10605 | 0.0054 | -0.0939 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1209 | 70 | 4093 | 0.0171 | -0.3952 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1235 | 86 | 4513 | 0.0191 | -0.3507 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1209 | 89 | 4093 | 0.0219 | -0.3884 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1401 | 91 | 4223 | 0.0217 | -0.4642 |
| Hs 578T | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 658 | 103 | 3846 | 0.0270 | -0.1739 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1235 | 108 | 4513 | 0.0241 | -0.3439 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1401 | 109 | 4223 | 0.0258 | -0.4581 |
| BT-20 | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 1097 | 119 | 3769 | 0.0317 | -0.3658 |
| Hs 578T | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 658 | 125 | 3846 | 0.0327 | -0.1670 |
| MDA-MB-231 | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 131 | 4513 | 0.0291 | -0.3370 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 962 | 136 | 10605 | 0.0128 | -0.0857 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 658 | 147 | 3846 | 0.0384 | -0.1601 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 658 | 154 | 3846 | 0.0401 | -0.1581 |
| BT-20 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1097 | 158 | 3769 | 0.0419 | -0.3515 |
| MCF7 | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 170 | 4093 | 0.0415 | -0.3605 |
| MCF 10A | A443654 | 10.0 | uM | LJP6 | 72 | hr | 962 | 173 | 10605 | 0.0164 | -0.0818 |
| Hs 578T | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 658 | 183 | 3846 | 0.0476 | -0.1491 |
| Hs 578T | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 658 | 184 | 3846 | 0.0480 | -0.1485 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 1235 | 185 | 4513 | 0.0411 | -0.3204 |
| MCF 10A | WZ3105 | 10.0 | uM | LJP5 | 72 | hr | 962 | 185 | 10605 | 0.0175 | -0.0806 |
| Hs 578T | WH-4-025 | 10.0 | uM | LJP5 | 72 | hr | 658 | 186 | 3846 | 0.0484 | -0.1481 |