LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1401 | 91 | 4223 | 0.0217 | -0.4642 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1401 | 109 | 4223 | 0.0258 | -0.4581 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1209 | 70 | 4093 | 0.0171 | -0.3952 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1209 | 89 | 4093 | 0.0219 | -0.3884 |
| BT-20 | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 1097 | 119 | 3769 | 0.0317 | -0.3658 |
| MCF7 | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 170 | 4093 | 0.0415 | -0.3605 |
| BT-20 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1097 | 158 | 3769 | 0.0419 | -0.3515 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1235 | 86 | 4513 | 0.0191 | -0.3507 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1235 | 108 | 4513 | 0.0241 | -0.3439 |
| SK-BR-3 | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 1401 | 443 | 4223 | 0.1050 | -0.3396 |
| MCF7 | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 1209 | 233 | 4093 | 0.0570 | -0.3386 |
| MDA-MB-231 | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 131 | 4513 | 0.0291 | -0.3370 |
| BT-20 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1097 | 201 | 3769 | 0.0535 | -0.3351 |
| BT-20 | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1097 | 211 | 3769 | 0.0562 | -0.3314 |
| SK-BR-3 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1401 | 486 | 4223 | 0.1151 | -0.3245 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 1235 | 185 | 4513 | 0.0411 | -0.3204 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 1235 | 205 | 4513 | 0.0455 | -0.3144 |
| SK-BR-3 | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 1401 | 516 | 4223 | 0.1222 | -0.3138 |
| MDA-MB-231 | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 234 | 4513 | 0.0518 | -0.3057 |
| SK-BR-3 | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1401 | 557 | 4223 | 0.1319 | -0.2993 |
| MDA-MB-231 | Celastrol | 10.0 | uM | LJP6 | 72 | hr | 1235 | 259 | 4513 | 0.0575 | -0.2980 |
| MDA-MB-231 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 259 | 4513 | 0.0575 | -0.2979 |
| MCF7 | JNK-9L | 3.33 | uM | LJP6 | 72 | hr | 1209 | 353 | 4093 | 0.0862 | -0.2971 |
| MDA-MB-231 | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 280 | 4513 | 0.0621 | -0.2916 |
| MDA-MB-231 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 283 | 4513 | 0.0628 | -0.2905 |