LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 962 | 57 | 10605 | 0.0054 | -0.0939 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 658 | 25 | 3846 | 0.0065 | -0.1986 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 658 | 35 | 3846 | 0.0091 | -0.1955 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 962 | 136 | 10605 | 0.0128 | -0.0857 |
| Hs 578T | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 658 | 53 | 3846 | 0.0140 | -0.1896 |
| MCF 10A | A443654 | 10.0 | uM | LJP6 | 72 | hr | 962 | 173 | 10605 | 0.0164 | -0.0818 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1209 | 70 | 4093 | 0.0171 | -0.3952 |
| MCF 10A | WZ3105 | 10.0 | uM | LJP5 | 72 | hr | 962 | 185 | 10605 | 0.0175 | -0.0806 |
| MCF 10A | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 962 | 194 | 10605 | 0.0183 | -0.0797 |
| MCF 10A | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 962 | 195 | 10605 | 0.0184 | -0.0795 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 962 | 200 | 10605 | 0.0189 | -0.0790 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1235 | 86 | 4513 | 0.0191 | -0.3507 |
| MCF 10A | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 962 | 204 | 10605 | 0.0192 | -0.0786 |
| MCF 10A | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 208 | 10605 | 0.0196 | -0.0782 |
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 962 | 211 | 10605 | 0.0199 | -0.0779 |
| MCF 10A | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 962 | 212 | 10605 | 0.0200 | -0.0778 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1401 | 91 | 4223 | 0.0217 | -0.4642 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1209 | 89 | 4093 | 0.0219 | -0.3884 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 962 | 236 | 10605 | 0.0223 | -0.0752 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 962 | 238 | 10605 | 0.0224 | -0.0751 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 962 | 245 | 10605 | 0.0231 | -0.0743 |
| MCF 10A | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 962 | 252 | 10605 | 0.0238 | -0.0736 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 962 | 253 | 10605 | 0.0239 | -0.0735 |
| MCF 10A | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 962 | 254 | 10605 | 0.0240 | -0.0734 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1235 | 108 | 4513 | 0.0241 | -0.3439 |