PCI-32765 KiNativ -- single dose experiment - Dataset (ID:20206)
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| Small Molecule | Cell Line | Protein | Sequence | Labeling Site | % Inhibition | Assay compound conc | Conc unit |
|---|---|---|---|---|---|---|---|
| Ibrutinib | Ramos (RA 1) | TEC | YVLDDQYTSSSGAKFPVK | Activation Loop | >90 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | BTK | YVLDDEYTSSVGSKFPVR | Activation Loop | 98.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK5 | YSVKVLPWLSPEVLQQNLQGYDAK | Activation Loop | -14.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TLK1/2 | YLNEIKPPIIHYDLKPGNILLVNGTACGEIK | Lys2 | -2.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TLK1 | YLNEIKPPIIHYDLKPGNILLVDGTACGEIK | Lys2 | -41.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | eEF2K | YIKYNSNSGFVR | ATP | -28.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FAK2 | YIEDEDYYKASVTR | Activation Loop | -12.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | JAK1_domain2 | YDPEGDNTGEQVAVKSLKPESGGNHIADLKK | Lys1 | -24.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MLTK | WISQDKEVAVKK | Lys1 | 28.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | CSK | VSDFGLTKEASSTQDTGKLPVK | Activation Loop | 25.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PI4KB | VPHTQAVVLNSKDK | ATP | 14.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3CD | VNWLAHNVSKDNRQ | ATP | -50.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKN1 | VLLSEFRPSGELFAIKALK | Lys1 | 7.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3CB | VFGEDSVGVIFKNGDDLR | ATP | 8.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LYN | VAVKTLKPGTMSVQAFLEEANLMK | Lys1 | -50.0 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | AMPKa1,AMPKa2 | VAVKILNR | Lys1 | 8.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | CHK2 | VAIKIISK | Lys1 | -1.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ACK | TVSVAVKCLKPDVLSQPEAMDDFIR | Lys1 | -39.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | TVAVKILK | Lys1 | 12.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FER | TSVAVKTCKEDLPQELK | Lys1 | -16.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PI42C | TLVIKEVSSEDIADMHSNLSNYHQYIVK | ATP | -87.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3C3 | TEDGGKYPVIFKHGDDLR | ATP | -7.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | NEK3 | SKNIFLTQNGK | Activation Loop | -7.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK6 | SIKASHILISGDGLVTLSGLSHLHSLVK | Lys2 | 16.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | AurB | SHFIVALKVLFK | Lys1 | -6.0 | 1 | uM |