PCI-32765 KiNativ -- single dose experiment - Dataset (ID:20206)
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| Small Molecule | Cell Line | Protein | Sequence | Labeling Site | % Inhibition | Assay compound conc | Conc unit |
|---|---|---|---|---|---|---|---|
| Ibrutinib | Ramos (RA 1) | NEK3 | SKNIFLTQNGK | Activation Loop | -7.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ABL,ARG | LMTGDTYTAHAGAKFPIK | Activation Loop | -12.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | BTK | YVLDDEYTSSVGSKFPVR | Activation Loop | 98.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FYN,SRC,YES | QGAKFPIKWTAPEAALYGR | Activation Loop | 7.8 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | BLK | IIDSEYTAQEGAKFPIK | Activation Loop | >99 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TEC | YVLDDQYTSSSGAKFPVK | Activation Loop | >90 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LCK | EGAKFPIKWTAPEAINYGTFTIK | Activation Loop | -2.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FAK2 | YIEDEDYYKASVTR | Activation Loop | -12.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | CSK | VSDFGLTKEASSTQDTGKLPVK | Activation Loop | 25.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ZAP70 | ISDFGLSKALGADDSYYTAR | Activation Loop | 10.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | ISDFGLSKALR | Activation Loop | 3.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK5 | YSVKVLPWLSPEVLQQNLQGYDAK | Activation Loop | -14.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FGR | LIKDDEYNPCQGSKFPIK | Activation Loop | 54.8 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LYN | EGAKFPIKWTAPEAINFGCFTIK | Activation Loop | -23.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FYV1 | GGKSGAAFYATEDDRFILK | ATP | -1.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3CD | VNWLAHNVSKDNRQ | ATP | -50.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | DNAPK | EHPFLVKGGEDLR | ATP | -20.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIP4K2A | AKELPTLKDNDFINEGQK | ATP | 0.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PI4KB | VPHTQAVVLNSKDK | ATP | 14.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3C3 | TEDGGKYPVIFKHGDDLR | ATP | -7.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | eEF2K | YIKYNSNSGFVR | ATP | -28.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ATR | FYIMMCKPK | ATP | -76.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FRAP1 | IQSIAPSLQVITSKQRPR | ATP | 0.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIK3CB | VFGEDSVGVIFKNGDDLR | ATP | 8.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PI42C | TLVIKEVSSEDIADMHSNLSNYHQYIVK | ATP | -87.5 | 1 | uM |