Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | BT-483 | -4.0000 | 0.8911 | -5.0552 | -5.0552 | -6.6573 | 0.5425 | 0.0000 | 0.2126 | 6.8792 |
| 17-AAG | BT-474 | -4.0000 | 0.9618 | -7.4900 | -7.3357 | -7.8068 | 1.8840 | 0.2443 | 0.2443 | 5.7024 |
| 17-AAG | BT-549 | -4.0000 | 0.9841 | -7.5275 | -7.5014 | -7.5490 | 3.9985 | 0.0952 | 0.0952 | 4.0970 |
| 5-DFUR | HCC1954 | -2.3010 | 0.9434 | -3.6450 | -3.5227 | -4.0170 | 0.5862 | 0.0763 | 0.2057 | 6.7630 |
| 5-DFUR | HCC1806 | -2.3010 | 0.9081 | -3.6850 | -3.6848 | -4.0833 | 0.4124 | 0.0000 | 0.2118 | 6.0697 |
| 5-DFUR | HCC202 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 5-DFUR | HCC1419 | -2.3010 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.2259 |
| 5-DFUR | HCC1428 | -2.3010 | 0.9488 | -3.0800 | -3.0800 | -4.1241 | 0.5954 | 0.0000 | 0.2607 | 7.0103 |
| 5-DFUR | HCC1569 | -2.3010 | 0.9182 | -2.3624 | -2.5871 | -3.3387 | 0.3978 | 0.0027 | 0.4755 | 7.5293 |
| 5-DFUR | HCC38 | -2.3010 | 0.9100 | -3.5578 | -3.3567 | -3.8397 | 0.5512 | 0.0979 | 0.2687 | 6.7165 |
| 5-DFUR | HCC1143 | -2.3010 | 0.9197 | -4.0670 | -3.4280 | -4.1667 | 0.5179 | 0.2667 | 0.3463 | 6.8120 |
| 5-DFUR | HCC1937 | -2.3010 | 0.9107 | -3.3200 | -2.6722 | -3.3787 | 0.8422 | 0.3577 | 0.4359 | 7.8002 |
| 5-DFUR | BT-483 | -2.3010 | 0.8857 | -1.9972 | -2.3010 | -4.0420 | 0.3377 | 0.0000 | 0.5556 | 7.6481 |
| 5-DFUR | BT-474 | -2.3010 | 0.8103 | -2.0940 | -2.3010 | -3.3351 | 0.3593 | 0.0000 | 0.5427 | 8.0229 |
| 5-DFUR | BT-549 | -2.3010 | 0.9520 | -3.6210 | -3.4398 | -3.6133 | 0.7796 | 0.1390 | 0.2126 | 6.7109 |
| 5-DFUR | CAMA-1 | -2.3010 | 0.8488 | -3.4620 | -2.3010 | -3.7320 | 0.5666 | 0.4131 | 0.5189 | 7.2984 |
| 5-DFUR | HCC1395 | -2.3010 | 0.7875 | -2.6523 | -2.6523 | -3.5298 | 0.4210 | 0.0000 | 0.4078 | 7.1221 |
| 5-DFUR | HCC70 | -2.3010 | 0.8809 | -2.8128 | -2.8128 | -3.6082 | 0.4174 | 0.0000 | 0.3784 | 7.2054 |
| 5-DFUR | BT-20 | -2.3010 | 0.8072 | -2.8957 | -2.4068 | -3.5554 | 0.5198 | 0.2009 | 0.4854 | 7.5241 |
| 5-DFUR | AU565 | -2.3010 | 0.8667 | -5.3030 | -4.3049 | -5.2191 | 0.5622 | 0.3626 | 0.3754 | 6.0160 |
| 5-DFUR | MDA-MB-231 | -2.3010 | 0.8760 | -3.4730 | -3.3613 | -3.4799 | 1.2300 | 0.1355 | 0.1657 | 7.6494 |
| 5-DFUR | SK-BR-3 | -2.3010 | 0.8096 | -2.5574 | -2.5574 | NaN | 0.2672 | 0.0000 | 0.4606 | 6.9216 |
| 5-DFUR | MCF7 | -2.3010 | 0.8187 | -3.6250 | -2.3010 | -3.8407 | 1.0180 | 0.5231 | 0.5436 | 7.6867 |
| 5-DFUR | MB 157 | -2.3010 | 0.9743 | -5.1030 | -4.9798 | -5.0609 | 3.9990 | 0.3398 | 0.3398 | 6.0249 |
| 5-DFUR | Hs 578T | -2.3010 | 0.9597 | -3.2156 | -3.2157 | -3.5345 | 0.5663 | 0.0000 | 0.2328 | 6.8530 |