Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | MCF 10A | -4.0000 | 0.9898 | -7.3650 | -7.3423 | -7.4309 | 2.4565 | 0.0490 | 0.0490 | 3.9543 |
| Bortezomib | HCC1143 | -3.7773 | 0.9884 | -7.3523 | -7.3420 | -7.4207 | 3.6360 | 0.0400 | 0.0400 | 3.6639 |
| Taxol | HCC1395 | -4.4776 | 0.8453 | -7.5906 | -7.3406 | -7.7382 | 1.9920 | 0.3410 | 0.3410 | 5.7644 |
| 17-AAG | BT-474 | -4.0000 | 0.9618 | -7.4900 | -7.3357 | -7.8068 | 1.8840 | 0.2443 | 0.2443 | 5.7024 |
| Triciribine | AU565 | -4.4776 | 0.9816 | -7.3716 | -7.3323 | -7.6135 | 0.7532 | 0.0324 | 0.0389 | 4.5358 |
| Ispinesib | MDA-MB-361 | -4.4776 | 0.9074 | -7.4466 | -7.3308 | -7.4990 | 3.9980 | 0.2389 | 0.2395 | 5.7432 |
| GSK461364 | SUM1315MO2 | -4.4776 | 0.9468 | -7.5016 | -7.3301 | -7.6637 | 2.4270 | 0.3088 | 0.3088 | 5.6429 |
| Vinorelbine | HCC1143 | -4.3335 | 0.7251 | -7.5695 | -7.3296 | -7.5171 | 3.9960 | 0.4451 | 0.4451 | 6.2724 |
| MG-132 | SUM159PT | -4.1759 | 0.9884 | -7.3269 | -7.3266 | -7.3432 | 3.6870 | 0.0020 | 0.0020 | 4.1503 |
| 17-AAG | MCF12A | -4.0000 | 0.9858 | -7.3260 | -7.3244 | -7.4672 | 2.5180 | 0.0545 | 0.0545 | 4.3677 |
| Ispinesib | MX1 | -4.4776 | 0.8838 | -7.4566 | -7.3196 | -7.5954 | 2.5790 | 0.2792 | 0.2792 | 5.4311 |
| Omipalisib | HCC1419 | -4.4776 | 0.9393 | -7.8176 | -7.3177 | -8.7550 | 0.7216 | 0.2822 | 0.2850 | 5.2439 |
| Topotecan | HCC1806 | -3.9626 | 0.9858 | -7.3486 | -7.3172 | -7.6959 | 0.9514 | 0.0337 | 0.0343 | 3.9182 |
| Afatinib | MDA-MB-175-VII | -4.1759 | 0.8569 | -7.3239 | -7.3144 | -8.2297 | 0.7557 | 0.0082 | 0.0124 | 3.9564 |
| Ispinesib | BT-549 | -4.4776 | 0.9010 | -7.3781 | -7.3129 | -7.3485 | 3.9965 | 0.2244 | 0.2244 | 5.7503 |
| Ispinesib | HCC38 | -4.4776 | 0.9431 | -7.3721 | -7.3108 | -7.4034 | 3.6725 | 0.2012 | 0.2012 | 5.2042 |
| GSK461364 | MDA-MB-436 | -4.4776 | 0.8119 | -7.8636 | -7.3063 | -7.8969 | 2.3230 | 0.3729 | 0.3729 | 6.0263 |
| Bortezomib | T47D | -3.7773 | 0.9910 | -7.3053 | -7.3057 | -7.4319 | 3.2440 | 0.0000 | 0.0000 | 3.3783 |
| 17-AAG | MCF 10F | -4.0000 | 0.9743 | -7.3525 | -7.3037 | -7.4975 | 2.2345 | 0.1044 | 0.1044 | 4.2062 |
| Bortezomib | MDA-MB-157 | -3.7773 | 0.9927 | -7.3033 | -7.3015 | -7.4332 | 3.1570 | 0.0074 | 0.0074 | 3.4694 |
| Torkinib | MCF 10A | -4.3010 | 0.9476 | -7.6170 | -7.2991 | -7.5499 | 0.5381 | 0.1629 | 0.1764 | 4.6086 |
| 17-AAG | SUM185PE | -4.0000 | 0.8775 | -7.3695 | -7.2978 | -7.5310 | 3.1600 | 0.1923 | 0.1923 | 4.8675 |
| Docetaxel | LY2 | -5.0000 | 0.9638 | -8.2275 | -7.2971 | -8.2340 | 1.5105 | 0.3819 | 0.3819 | 5.9691 |
| MG-132 | MCF12A | -4.1759 | 0.9807 | -7.3074 | -7.2965 | -7.4021 | 2.3635 | 0.0289 | 0.0289 | 4.0023 |
| Ispinesib | HCC70 | -4.4776 | 0.9590 | -7.3376 | -7.2934 | -7.4217 | 4.0000 | 0.1686 | 0.1686 | 5.1351 |