Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Taxol | HCC1143 | -4.4776 | 0.9579 | -7.6816 | -7.4738 | -7.8328 | 1.7125 | 0.2784 | 0.2784 | 5.4383 |
| Omipalisib | ZR-75-1 | -4.4776 | 0.9752 | -7.6386 | -7.4713 | -8.0848 | 0.9233 | 0.1479 | 0.1496 | 4.7729 |
| Torkinib | HCC1143 | -4.3010 | 0.9605 | -7.8290 | -7.4652 | -8.7515 | 0.3324 | 0.1215 | 0.1768 | 4.2921 |
| Geldanamycin | T47D | -4.0000 | 0.9769 | -7.6310 | -7.4618 | -7.8048 | 3.1990 | 0.3566 | 0.3566 | 5.2630 |
| Vinorelbine | HCC3153 | -4.3335 | 0.8153 | -7.5355 | -7.4557 | -7.5455 | 3.9990 | 0.2594 | 0.2594 | 4.9844 |
| GSK923295 | HCC1187 | -4.4776 | 0.9843 | -7.4796 | -7.4551 | -7.6694 | 3.9940 | 0.0876 | 0.0876 | 4.5239 |
| Topotecan | SUM52PE | -3.9626 | 0.9535 | -7.5856 | -7.4538 | -8.0542 | 0.9009 | 0.1195 | 0.1200 | 4.0015 |
| Ispinesib | SUM229PE | -4.4776 | 0.9533 | -7.5186 | -7.4534 | -7.5716 | 2.1870 | 0.1392 | 0.1392 | 4.7222 |
| Docetaxel | UACC-893 | -5.0000 | 0.8516 | -7.7670 | -7.4530 | -7.8897 | 3.9970 | 0.4722 | 0.4722 | 7.5379 |
| Docetaxel | MDA-MB-436 | -5.0000 | 0.8183 | -7.7540 | -7.4465 | -7.7477 | 3.9940 | 0.4703 | 0.4703 | 6.9177 |
| Ispinesib | HCC1395 | -4.4776 | 0.9518 | -7.5201 | -7.4459 | -7.7305 | 2.6980 | 0.1555 | 0.1555 | 4.9063 |
| Gemcitabine | MCF12A | -3.8416 | 0.9832 | -7.5536 | -7.4446 | -7.6193 | 1.3900 | 0.1477 | 0.1477 | 4.0962 |
| Vinorelbine | MDA-MB-436 | -4.3335 | 0.8865 | -7.6845 | -7.4414 | -7.6361 | 2.1830 | 0.3079 | 0.3079 | 5.5398 |
| Torkinib | HCC1428 | -4.3010 | 0.7953 | -7.7250 | -7.4406 | -9.2993 | 0.2643 | 0.0796 | 0.1814 | 4.2525 |
| Torkinib | HCC2185 | -4.3010 | 0.9758 | -8.3570 | -7.4396 | -9.6944 | 0.4359 | 0.3010 | 0.3127 | 4.7229 |
| Bortezomib | HCC202 | -3.7773 | 0.9805 | -7.4423 | -7.4370 | -7.6511 | 3.9990 | 0.0253 | 0.0253 | 3.4375 |
| 17-AAG | SUM159PT | -4.0000 | 0.9526 | -7.4530 | -7.4356 | -7.4727 | 2.8720 | 0.0503 | 0.0503 | 3.8932 |
| Ispinesib | HCC3153 | -4.4776 | 0.9539 | -7.5121 | -7.4331 | -7.6119 | 3.0430 | 0.1960 | 0.1960 | 5.0904 |
| GSK923295 | SUM159PT | -4.4776 | 0.8759 | -7.4856 | -7.4327 | -7.4703 | 3.2010 | 0.1772 | 0.1772 | 5.4892 |
| Ispinesib | SUM1315MO2 | -4.4776 | 0.9763 | -7.4726 | -7.4316 | -7.5730 | 3.9990 | 0.1567 | 0.1567 | 4.9996 |
| GSK923295 | HCC70 | -4.4776 | 0.9633 | -7.5556 | -7.4313 | -7.6963 | 3.4200 | 0.2869 | 0.2869 | 5.6469 |
| Geldanamycin | SK-BR-3 | -4.0000 | 0.9704 | -7.8485 | -7.4310 | -7.8868 | 1.7040 | 0.3960 | 0.3960 | 5.6592 |
| Ispinesib | MDA-MB-453 | -4.4776 | 0.9397 | -7.4946 | -7.4292 | -7.5398 | 3.9990 | 0.2265 | 0.2265 | 5.3584 |
| Afatinib | MCF 10A | -4.1759 | 0.9681 | -7.4799 | -7.4254 | -7.5242 | 1.4410 | 0.0821 | 0.0821 | 4.2860 |
| Ispinesib | MCF 10A | -4.4776 | 0.9598 | -7.4736 | -7.4230 | -7.4650 | 1.8090 | 0.0891 | 0.0891 | 4.5750 |