Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC70 | -4.3010 | 0.9415 | -9.6690 | -9.5655 | -12.1070 | 0.3058 | 0.0350 | 0.0565 | 2.0727 |
| Erlotinib | 600MPE | -4.1759 | 0.7785 | -2.9179 | -4.1759 | -4.4247 | 0.3062 | 0.0000 | 0.7082 | 8.1894 |
| CGC-11047 | BT-549 | -2.3010 | 0.8254 | -4.3850 | -4.3848 | NaN | 0.3120 | 0.0000 | 0.1835 | 5.2583 |
| CGC-11047 | Hs 578T | -2.3010 | 0.7333 | -3.5660 | -3.5658 | NaN | 0.3139 | 0.0000 | 0.2862 | 6.0454 |
| Temsirolimus | SUM225CWN | -3.8761 | 0.8593 | -6.0851 | -6.0846 | NaN | 0.3143 | 0.0000 | 0.1682 | 4.9875 |
| Everolimus | HCC1143 | -4.1759 | 0.7354 | -5.4069 | -5.4069 | NaN | 0.3199 | 0.0000 | 0.2877 | 6.1721 |
| Triciribine | SUM52PE | -4.4776 | 0.9249 | -4.5540 | -4.5540 | -5.6806 | 0.3205 | 0.0000 | 0.4859 | 7.3979 |
| Ixabepilone | HCC1428 | -4.4045 | 0.8023 | -5.7990 | -5.7992 | NaN | 0.3205 | 0.0000 | 0.2642 | 6.0222 |
| (Z)-4-Hydroxytamoxifen | HCC1428 | -3.7773 | 0.7209 | -4.2667 | -4.2667 | NaN | 0.3206 | 0.0000 | 0.4106 | 6.8703 |
| 5-DFUR | 184B5 | -2.3010 | 0.8541 | -2.7726 | -2.7726 | -3.6487 | 0.3219 | 0.0000 | 0.4135 | 7.0046 |
| Temsirolimus | MDA-MB-453 | -3.8761 | 0.8964 | -5.9381 | -5.8199 | -7.1002 | 0.3240 | 0.0423 | 0.2116 | 5.5554 |
| Everolimus | SK-BR-3 | -4.1759 | 0.7413 | -5.3239 | -5.3235 | -6.7240 | 0.3266 | 0.0001 | 0.2967 | 6.5953 |
| Everolimus | UACC-893 | -4.1759 | 0.7818 | -4.6489 | -4.6489 | NaN | 0.3277 | 0.0000 | 0.4117 | 7.0389 |
| Erlotinib | HCC1937 | -4.1759 | 0.7956 | -3.4676 | -4.1759 | -4.3929 | 0.3278 | 0.0000 | 0.6306 | 7.8944 |
| Temsirolimus | MCF 10A | -3.8761 | 0.8618 | -6.1221 | -6.1219 | NaN | 0.3292 | 0.0000 | 0.1542 | 5.0694 |
| CGC-11047 | HCC1937 | -2.3010 | 0.8954 | -4.0020 | -4.0022 | NaN | 0.3294 | 0.0000 | 0.2236 | 5.7607 |
| Temsirolimus | HCC1143 | -3.8761 | 0.7860 | -5.3661 | -5.3657 | NaN | 0.3305 | 0.0000 | 0.2435 | 5.8156 |
| Torkinib | MDA-MB-134-VI | -4.3010 | 0.9644 | -8.3700 | -8.1441 | -9.5949 | 0.3310 | 0.0793 | 0.1189 | 3.4999 |
| Torkinib | HCC1143 | -4.3010 | 0.9605 | -7.8290 | -7.4652 | -8.7515 | 0.3324 | 0.1215 | 0.1768 | 4.2921 |
| Torkinib | HCC1954 | -4.3010 | 0.9756 | -8.3140 | -8.0526 | -8.9641 | 0.3341 | 0.0911 | 0.1308 | 3.6259 |
| Ixabepilone | SUM185PE | -4.4045 | 0.8184 | -6.3905 | -6.3904 | NaN | 0.3353 | 0.0000 | 0.1775 | 5.2632 |
| Temsirolimus | CAMA-1 | -3.8761 | 0.9061 | -6.1471 | -6.1472 | -7.3708 | 0.3358 | 0.0000 | 0.1473 | 5.1614 |
| Temsirolimus | LY2 | -3.8761 | 0.7428 | -5.4146 | -5.4148 | NaN | 0.3363 | 0.0000 | 0.2349 | 5.8972 |
| Temsirolimus | T47D | -3.8761 | 0.8509 | -5.3241 | -5.3243 | NaN | 0.3370 | 0.0000 | 0.2453 | 5.8882 |
| 5-DFUR | BT-483 | -2.3010 | 0.8857 | -1.9972 | -2.3010 | -4.0420 | 0.3377 | 0.0000 | 0.5556 | 7.6481 |