Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | HCC1395 | -4.0000 | 0.8972 | -5.9790 | -5.7146 | -6.7611 | 0.5356 | 0.1172 | 0.1989 | 6.3873 |
| Afatinib | SUM225CWN | -4.1759 | 0.9306 | -7.2619 | -7.1185 | -7.9561 | 0.5364 | 0.0814 | 0.1012 | 4.5543 |
| Torkinib | MCF 10A | -4.3010 | 0.9476 | -7.6170 | -7.2991 | -7.5499 | 0.5381 | 0.1629 | 0.1764 | 4.6086 |
| GSK1070916 | MCF 10A | -4.4776 | 0.9215 | -5.9786 | -5.8636 | -6.1244 | 0.5384 | 0.0605 | 0.1962 | 6.4581 |
| Torkinib | SUM159PT | -4.3010 | 0.9779 | -8.4820 | -8.2954 | -8.5069 | 0.5401 | 0.1033 | 0.1082 | 3.3095 |
| Pevonedistat | HCC1569 | -4.1759 | 0.8469 | -5.8629 | -4.1759 | -5.6430 | 0.5406 | 0.5928 | 0.6372 | 7.9236 |
| Etoposide | MDA-MB-134-VI | -3.4776 | 0.9497 | -4.8486 | -4.0551 | -5.6362 | 0.5406 | 0.3137 | 0.4192 | 7.2305 |
| Sigma A6730 | ZR75B | -4.1759 | 0.8789 | -5.5489 | -5.5491 | -6.0252 | 0.5413 | 0.0000 | 0.1530 | 6.1355 |
| 17-AAG | BT-483 | -4.0000 | 0.8911 | -5.0552 | -5.0552 | -6.6573 | 0.5425 | 0.0000 | 0.2126 | 6.8792 |
| Temsirolimus | HCC1428 | -3.8761 | 0.7918 | -4.8098 | -4.8099 | -5.8112 | 0.5428 | 0.0000 | 0.2390 | 6.4956 |
| Etoposide | MX1 | -3.4776 | 0.9631 | -5.3256 | -5.3256 | -6.3576 | 0.5445 | 0.0000 | 0.0897 | 5.6932 |
| Topotecan | LY2 | -3.9626 | 0.9546 | -6.1176 | -5.9119 | -6.6278 | 0.5455 | 0.1140 | 0.1694 | 5.8004 |
| 5-FU | CAMA-1 | -1.7167 | 0.8554 | -2.8017 | -2.6620 | -3.6658 | 0.5456 | 0.0805 | 0.2678 | 6.8685 |
| Torkinib | AU565 | -4.3010 | 0.9687 | -8.5760 | -8.0828 | -8.9348 | 0.5460 | 0.2310 | 0.2346 | 4.0207 |
| GSK1070916 | HCC38 | -4.4776 | 0.9041 | -5.7636 | -5.7637 | -6.4859 | 0.5460 | 0.0000 | 0.1725 | 6.4217 |
| GSK1070916 | SUM229PE | -4.4776 | 0.9250 | -5.8586 | -5.8590 | -6.2571 | 0.5466 | 0.0000 | 0.1495 | 6.3665 |
| 5-FU | LY2 | -1.7167 | 0.9749 | -3.8857 | -3.8164 | -4.4427 | 0.5471 | 0.0000 | 0.0640 | 5.5675 |
| CGC-11047 | HCC1419 | -2.3010 | 0.8675 | -3.3720 | -3.3718 | -4.8529 | 0.5490 | 0.0000 | 0.2061 | 6.4600 |
| Omipalisib | SUM225CWN | -4.4776 | 0.9049 | -8.0816 | -7.7460 | -8.7709 | 0.5508 | 0.1734 | 0.1819 | 4.3953 |
| Sigma A6730 | ZR-75-1 | -4.1759 | 0.8786 | -5.2271 | -5.1490 | -6.1834 | 0.5509 | 0.0549 | 0.2948 | 6.7180 |
| Etoposide | SUM149PT | -3.4776 | 0.9480 | -5.2386 | -5.2383 | -5.5955 | 0.5509 | 0.0000 | 0.0968 | 5.9119 |
| 5-DFUR | HCC38 | -2.3010 | 0.9100 | -3.5578 | -3.3567 | -3.8397 | 0.5512 | 0.0979 | 0.2687 | 6.7165 |
| NU6102 | SK-BR-3 | -4.1759 | 0.7066 | -3.9293 | -4.1759 | -4.5202 | 0.5514 | 0.0000 | 0.5776 | 8.0143 |
| Tozasertib | HCC1569 | -4.0000 | 0.9023 | -5.0220 | -5.0220 | -5.7245 | 0.5522 | 0.0000 | 0.2143 | 6.7476 |
| Omipalisib | MDA-MB-453 | -4.4776 | 0.9438 | -7.6551 | -7.6413 | -8.4034 | 0.5528 | 0.0102 | 0.0332 | 3.9920 |