Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 5-FU | BT-483 | -1.7167 | 0.9825 | -3.1657 | -2.8988 | -4.4387 | 0.5142 | 0.1355 | 0.2673 | 6.7117 |
| Omipalisib | BT-483 | -4.4776 | 0.9810 | -7.7216 | -7.1924 | -8.8962 | 0.5153 | 0.2330 | 0.2490 | 5.0745 |
| Afatinib | MDA-MB-468 | -4.1759 | 0.9052 | -6.0229 | -6.0233 | -6.3015 | 0.5159 | 0.0000 | 0.1002 | 5.5156 |
| Topotecan | ZR-75-1 | -3.9626 | 0.9706 | -6.9426 | -6.6284 | -7.5222 | 0.5168 | 0.1561 | 0.1801 | 5.0278 |
| GSK1070916 | HCC1569 | -4.4776 | 0.9060 | -5.6529 | -5.6530 | -6.1004 | 0.5168 | 0.0000 | 0.2019 | 6.5482 |
| 5-DFUR | HCC1143 | -2.3010 | 0.9197 | -4.0670 | -3.4280 | -4.1667 | 0.5179 | 0.2667 | 0.3463 | 6.8120 |
| 5-DFUR | BT-20 | -2.3010 | 0.8072 | -2.8957 | -2.4068 | -3.5554 | 0.5198 | 0.2009 | 0.4854 | 7.5241 |
| PD173074 | SUM52PE | -4.4776 | 0.8683 | -7.4756 | -6.9774 | -7.7068 | 0.5208 | 0.2247 | 0.2454 | 5.3107 |
| Tozasertib | 184A1 | -4.0000 | 0.9510 | -5.1140 | -5.1141 | -5.7005 | 0.5227 | 0.0000 | 0.2074 | 6.6019 |
| 5-FU | MDA-MB-436 | -1.7167 | 0.7179 | -2.7477 | -2.4610 | -3.3629 | 0.5233 | 0.1459 | 0.3373 | 7.2900 |
| Oxaliplatin | ZR75B | -3.2013 | 0.9141 | -4.7143 | -4.7144 | -5.5795 | 0.5251 | 0.0000 | 0.1383 | 6.3525 |
| 5-DFUR | HCC2185 | -2.3010 | 0.8231 | -1.9221 | -2.3010 | -3.8435 | 0.5251 | 0.0000 | 0.6126 | 8.3218 |
| 5-FU | MCF7 | -1.7167 | 0.9467 | -3.7182 | -3.5542 | -4.3345 | 0.5254 | 0.0859 | 0.1618 | 5.9745 |
| Gemcitabine | CAMA-1 | -3.8416 | 0.8152 | -7.2376 | -3.8416 | -6.5058 | 0.5254 | 0.6609 | 0.6664 | 7.2283 |
| 5-DFUR | 184A1 | -2.3010 | 0.9310 | -2.9819 | -2.9819 | -3.6467 | 0.5276 | 0.0000 | 0.3042 | 7.3885 |
| Temsirolimus | UACC-812 | -3.8761 | 0.8946 | -5.2671 | -5.2667 | -6.3206 | 0.5283 | 0.0000 | 0.1556 | 6.1769 |
| Oxaliplatin | HCC1954 | -3.2013 | 0.9673 | -5.0373 | -5.0375 | -5.6019 | 0.5312 | 0.0000 | 0.0957 | 5.7405 |
| Carboplatin | BT-483 | -2.8697 | 0.8733 | -4.5517 | -4.0027 | -5.7599 | 0.5318 | 0.2447 | 0.3301 | 6.8846 |
| Lestaurtinib | ZR-75-1 | -4.4776 | 0.8071 | -4.9951 | -4.9951 | -5.8634 | 0.5333 | 0.0000 | 0.3460 | 7.1442 |
| Etoposide | MDA-MB-157 | -3.4776 | 0.9397 | -5.2866 | -5.2864 | -6.0724 | 0.5334 | 0.0000 | 0.0978 | 5.7275 |
| 17-AAG | SK-BR-3 | -4.0000 | 0.8661 | -7.1800 | -6.4291 | -7.4935 | 0.5343 | 0.2889 | 0.2896 | 5.6780 |
| 5-DFUR | MCF12A | -2.3010 | 0.9769 | -4.4605 | -4.4604 | -4.8749 | 0.5344 | 0.0000 | 0.0680 | 5.3277 |
| Everolimus | SUM1315MO2 | -4.1759 | 0.7626 | -5.0016 | -5.0015 | -5.8879 | 0.5348 | 0.0000 | 0.2657 | 6.7223 |
| Trametinib | HCC1954 | -4.7773 | 0.7566 | -7.3333 | -4.7773 | -5.6595 | 0.5350 | 0.6386 | 0.6535 | 6.9646 |
| GSK1070916 | Hs 578T | -4.4776 | 0.9154 | -5.9386 | -5.9390 | -6.4229 | 0.5351 | 0.0000 | 0.1410 | 6.1417 |