Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| CGC-11144 | Hs 578T | -3.1500 | 0.9195 | -4.7950 | -4.7948 | -4.9516 | 1.6600 | 0.0000 | 0.0059 | 5.9958 |
| Fascaplysin | MDA-MB-231 | -4.4776 | 0.9406 | -6.5876 | -6.5862 | -6.6577 | 2.9670 | 0.0058 | 0.0059 | 5.6606 |
| Imatinib | MCF 10F | -3.2480 | 0.9698 | -4.5325 | -4.5326 | -4.7421 | 2.4455 | 0.0000 | 0.0059 | 6.8208 |
| MG-132 | MDA-MB-157 | -4.1759 | 0.9925 | -6.6299 | -6.6281 | -6.8061 | 2.2520 | 0.0058 | 0.0059 | 5.0640 |
| Trichostatin A | MDA-MB-157 | -2.3010 | 0.9870 | -4.5220 | -4.5205 | -4.7920 | 2.0590 | 0.0060 | 0.0060 | 5.2276 |
| Vorinostat | HCC1806 | -1.7282 | 0.9701 | -3.7827 | -3.7802 | -3.9185 | 1.3230 | 0.0040 | 0.0060 | 5.4870 |
| Sunitinib | MDA-MB-157 | -3.7773 | 0.9732 | -5.1423 | -5.1219 | -5.2297 | 3.9920 | 0.0060 | 0.0060 | 6.5503 |
| Bosutinib | SUM149PT | -4.0000 | 0.9696 | -6.0195 | -6.0187 | -6.1801 | 1.1295 | 0.0009 | 0.0061 | 5.4414 |
| Trichostatin A | MCF 10A | -2.3010 | 0.9831 | -4.7880 | -4.7805 | -4.8665 | 1.2940 | 0.0055 | 0.0061 | 5.0583 |
| Cisplatin | HCC1187 | -3.6021 | 0.9657 | -5.3771 | -5.3723 | -5.6732 | 2.5350 | 0.0062 | 0.0062 | 6.1692 |
| NSC 663284 | ZR-75-1 | -3.7773 | 0.9140 | -5.6198 | -5.6188 | -6.0060 | 1.4630 | 0.0018 | 0.0062 | 5.4328 |
| Afatinib | T47DKBLUC | -4.1759 | 0.9804 | -5.3209 | -5.3199 | -5.4110 | 3.9990 | 0.0061 | 0.0062 | 6.7041 |
| Carboplatin | 184B5 | -2.8697 | 0.9700 | -4.9237 | -4.9237 | -5.2930 | 1.0740 | 0.0000 | 0.0062 | 5.6519 |
| NSC 663284 | HCC1569 | -3.7773 | 0.9759 | -5.3183 | -5.3169 | -5.4529 | 3.1100 | 0.0063 | 0.0063 | 6.2815 |
| MG-132 | Hs 578T | -4.1759 | 0.9796 | -6.6819 | -6.6802 | -6.7357 | 3.3020 | 0.0063 | 0.0063 | 4.8941 |
| Olomoucine II | HCC1187 | -3.8761 | 0.9860 | -5.0731 | -5.0708 | -5.2124 | 2.7620 | 0.0058 | 0.0063 | 6.8131 |
| Olomoucine II | MX1 | -3.8761 | 0.9589 | -5.0991 | -5.0973 | -5.2469 | 2.4920 | 0.0000 | 0.0064 | 7.0652 |
| Vorinostat | SUM52PE | -1.7282 | 0.8570 | -4.3732 | -4.3733 | -4.8038 | 0.8273 | 0.0000 | 0.0064 | 4.5057 |
| NSC 663284 | SUM52PE | -3.7773 | 0.9684 | -5.4738 | -5.4714 | -5.6536 | 2.1165 | 0.0060 | 0.0064 | 6.1086 |
| Fascaplysin | ZR-75-1 | -4.4776 | 0.9876 | -6.3036 | -6.3012 | -6.4821 | 2.4065 | 0.0064 | 0.0064 | 5.9147 |
| Imatinib | MCF12A | -3.2480 | 0.9668 | -4.4045 | -4.4029 | -4.4579 | 3.4055 | 0.0060 | 0.0065 | 6.9187 |
| Baicalein | SUM159PT | -3.7773 | 0.7209 | -4.3232 | -4.3232 | -4.3449 | 3.9990 | 0.0000 | 0.0065 | 8.7764 |
| GSK1838705A | HCC38 | -4.1759 | 0.9258 | -5.0423 | -5.0415 | -5.1211 | 2.7700 | 0.0026 | 0.0065 | 7.0266 |
| Bortezomib | MDA-MB-468 | -3.7773 | 0.9712 | -7.0783 | -7.0761 | -7.1476 | 3.2220 | 0.0066 | 0.0066 | 3.7763 |
| Imatinib | SUM229PE | -3.2480 | 0.9703 | -4.8160 | -4.8152 | -5.0068 | 2.6580 | 0.0042 | 0.0066 | 6.0697 |