Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Sigma A6730 | HCC1806 | -4.1759 | 0.9903 | -4.9814 | -4.9814 | -5.0839 | 2.1260 | 0.0000 | 0.0190 | 7.2872 |
| Sigma A6730 | HCC1937 | -4.1759 | 0.9431 | -4.8104 | -4.8104 | -5.0396 | 1.9990 | 0.0000 | 0.0511 | 7.2097 |
| Imatinib | BT-549 | -3.2480 | 0.9758 | -4.5030 | -4.5034 | -4.5287 | 3.7630 | 0.0000 | 0.0000 | 6.9489 |
| GSK461364 | HCC1569 | -4.4776 | 0.7965 | -5.0714 | -5.0714 | -5.7745 | 0.3696 | 0.0000 | 0.3763 | 6.5207 |
| Sigma A6730 | HCC38 | -4.1759 | 0.8843 | -4.8284 | -4.8283 | -4.9506 | 2.3505 | 0.0000 | 0.0319 | 7.0821 |
| Tozasertib | BT-20 | -4.0000 | 0.8366 | -4.6124 | -4.6124 | -5.5324 | 0.4999 | 0.0000 | 0.3307 | 7.0328 |
| Sigma A6730 | Hs 578T | -4.1759 | 0.9739 | -4.8110 | -4.8109 | -4.8932 | 2.1090 | 0.0000 | 0.0438 | 7.4401 |
| Erlotinib | MX1 | -4.1759 | 0.8827 | -4.4066 | -4.4066 | -5.2452 | 0.5878 | 0.0000 | 0.4226 | 7.5566 |
| Sigma A6730 | MDA-MB-134-VI | -4.1759 | 0.9175 | -4.7669 | -4.7670 | -5.1323 | 2.1400 | 0.0000 | 0.0612 | 7.3376 |
| Tozasertib | BT-474 | -4.0000 | 0.8143 | -4.4178 | -4.4177 | -5.1819 | 1.5550 | 0.0000 | 0.1831 | 7.9621 |
| Sigma A6730 | MDA-MB-175-VII | -4.1759 | 0.9535 | -5.0331 | -5.0332 | -5.7470 | 1.2140 | 0.0000 | 0.0834 | 7.1844 |
| Sigma A6730 | MDA-MB-361 | -4.1759 | 0.9863 | -5.2799 | -5.2801 | -6.0459 | 1.0060 | 0.0000 | 0.0741 | 6.8148 |
| Sigma A6730 | MDA-MB-436 | -4.1759 | 0.8912 | -4.4922 | -4.4922 | -4.3132 | 2.3540 | 0.0000 | 0.1526 | 8.5230 |
| Sigma A6730 | MDA-MB-453 | -4.1759 | 0.9721 | -5.4519 | -5.4518 | -5.7281 | 1.4410 | 0.0000 | 0.0143 | 6.6250 |
| Sigma A6730 | MDA-MB-468 | -4.1759 | 0.9044 | -4.9020 | -4.9019 | -4.9932 | 1.2880 | 0.0000 | 0.1040 | 7.0804 |
| GSK461364 | T47D | -4.4776 | 0.7866 | -4.9834 | -4.9834 | -6.1129 | 1.8790 | 0.0000 | 0.1008 | 7.2108 |
| GSK461364 | BT-483 | -4.4776 | 0.8228 | -4.9223 | -4.9223 | -5.7449 | 2.2735 | 0.0000 | 0.0889 | 7.5231 |
| Sigma A6730 | UACC-893 | -4.1759 | 0.9084 | -5.0650 | -5.0649 | -6.4435 | 1.0760 | 0.0000 | 0.0995 | 6.7347 |
| Imatinib | HCC1937 | -3.2480 | 0.9771 | -4.5720 | -4.5718 | -4.6962 | 2.4660 | 0.0000 | 0.0005 | 6.3870 |
| Sigma A6730 | 184B5 | -4.1759 | 0.8439 | -5.3859 | -5.3864 | -5.6327 | 1.1690 | 0.0000 | 0.0370 | 6.3035 |
| Sigma A6730 | HCC1187 | -4.1759 | 0.9519 | -5.1336 | -5.1336 | -5.4641 | 1.0721 | 0.0000 | 0.0866 | 6.9207 |
| Sigma A6730 | MCF 10A | -4.1759 | 0.9265 | -5.2509 | -5.2511 | -5.3485 | 1.1130 | 0.0000 | 0.0598 | 6.9784 |
| Sigma A6730 | MCF 10F | -4.1759 | 0.9724 | -5.1739 | -5.1737 | -5.4463 | 0.9561 | 0.0000 | 0.1000 | 6.8338 |
| Bosutinib | SK-BR-3 | -4.0000 | 0.8715 | -5.1340 | -5.1339 | -5.5027 | 0.9151 | 0.0000 | 0.0840 | 6.5434 |
| Sunitinib | HCC2185 | -3.7773 | 0.9682 | -4.7913 | -4.7911 | -4.9707 | 2.5710 | 0.0000 | 0.0025 | 7.1741 |