Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Taxol | MCF12A | -4.4776 | 0.9575 | -7.9916 | -7.8720 | -7.9736 | 3.9900 | 0.3105 | 0.3105 | 5.1298 |
| LBH589 | MCF 10A | -4.4776 | 0.9680 | -6.8196 | -6.8174 | -6.8899 | 1.5830 | 0.0037 | 0.0039 | 5.1318 |
| MG-132 | HCC1806 | -4.1759 | 0.9957 | -6.5159 | -6.5125 | -6.5782 | 3.0970 | 0.0133 | 0.0133 | 5.1323 |
| Epirubicin | SUM229PE | -3.7645 | 0.9624 | -6.5365 | -6.4531 | -6.6309 | 1.7540 | 0.1432 | 0.1432 | 5.1324 |
| Ispinesib | HCC70 | -4.4776 | 0.9590 | -7.3376 | -7.2934 | -7.4217 | 4.0000 | 0.1686 | 0.1686 | 5.1351 |
| LBH589 | HCC2185 | -4.4776 | 0.9700 | -6.8851 | -6.8798 | -7.1914 | 2.3935 | 0.0146 | 0.0146 | 5.1373 |
| LBH589 | UACC-893 | -4.4776 | 0.9761 | -7.0046 | -6.9947 | -7.3599 | 2.3230 | 0.0257 | 0.0257 | 5.1391 |
| Docetaxel | MCF12A | -5.0000 | 0.9298 | -8.6260 | -8.2368 | -8.6178 | 1.3250 | 0.3435 | 0.3436 | 5.1394 |
| Temsirolimus | MB 157 | -3.8761 | 0.8548 | -6.0781 | -6.0777 | NaN | 0.2809 | 0.0000 | 0.1940 | 5.1396 |
| XRP44X | HCC1954 | -3.8761 | 0.9458 | -6.3851 | -6.3213 | -6.4332 | 2.4930 | 0.1535 | 0.1535 | 5.1400 |
| MG-132 | HCC1569 | -4.1759 | 0.9861 | -6.6249 | -6.6125 | -6.7353 | 3.3455 | 0.0447 | 0.0447 | 5.1402 |
| Triciribine | SK-BR-3 | -4.4776 | 0.9794 | -7.1261 | -7.0205 | -7.3056 | 1.0085 | 0.1086 | 0.1106 | 5.1406 |
| Oxaliplatin | SUM159PT | -3.2013 | 0.9842 | -5.5843 | -5.5638 | -5.6109 | 1.1880 | 0.0302 | 0.0308 | 5.1424 |
| Fascaplysin | AU565 | -4.4776 | 0.9859 | -6.8296 | -6.8296 | -6.9778 | 1.3645 | 0.0002 | 0.0009 | 5.1441 |
| MG-132 | MCF 10F | -4.1759 | 0.8270 | -6.9319 | -6.8555 | -7.1224 | 1.8290 | 0.1368 | 0.1368 | 5.1467 |
| GSK1070916 | HCC1187 | -4.4776 | 0.9555 | -7.8256 | -7.7783 | -7.9254 | 3.9990 | 0.2321 | 0.2321 | 5.1468 |
| 5-FU | HCC1806 | -1.7167 | 0.9440 | -4.0882 | -4.0549 | -4.6127 | 0.4590 | 0.0168 | 0.0943 | 5.1471 |
| Vorinostat | UACC-893 | -1.7282 | 0.9833 | -4.0442 | -4.0369 | -4.3752 | 1.6240 | 0.0143 | 0.0145 | 5.1473 |
| Trichostatin A | MDA-MB-468 | -2.3010 | 0.9883 | -4.7270 | -4.7209 | -4.7933 | 3.0220 | 0.0201 | 0.0201 | 5.1476 |
| LBH589 | T47D | -4.4776 | 0.9808 | -6.7846 | -6.7806 | -6.8891 | 2.5960 | 0.0133 | 0.0133 | 5.1480 |
| Vorinostat | MDA-MB-361 | -1.7282 | 0.9885 | -3.9522 | -3.9523 | -4.2812 | 1.5620 | 0.0002 | 0.0007 | 5.1490 |
| LBH589 | HCC1143 | -4.4776 | 0.9211 | -7.0096 | -6.9462 | -7.1509 | 1.3210 | 0.0872 | 0.0876 | 5.1496 |
| Triciribine | MCF12A | -4.4776 | 0.9141 | -7.0446 | -6.8181 | -7.2326 | 0.4569 | 0.0969 | 0.1536 | 5.1533 |
| GSK1059615 | MCF 10F | -3.8761 | 0.9758 | -6.5361 | -6.4562 | -6.7332 | 0.9002 | 0.0756 | 0.0794 | 5.1553 |
| Ispinesib | MDA-MB-436 | -4.4776 | 0.8971 | -7.5336 | -7.3931 | -7.5268 | 1.9630 | 0.2348 | 0.2348 | 5.1565 |