Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | -4.3010 | 0.9476 | -7.6170 | -7.2991 | -7.5499 | 0.5381 | 0.1629 | 0.1764 | 4.6086 |
| Gemcitabine | SUM52PE | -3.8416 | 0.9073 | -8.0736 | -7.7371 | -8.1643 | 1.2920 | 0.3163 | 0.3163 | 4.6098 |
| Taxol | SUM52PE | -4.4776 | 0.9808 | -8.4026 | -7.9916 | -8.3327 | 2.0320 | 0.2643 | 0.2643 | 4.6139 |
| Geldanamycin | SUM185PE | -4.0000 | 0.9622 | -7.6670 | -7.5819 | -7.8045 | 3.2290 | 0.2000 | 0.2000 | 4.6139 |
| MG-132 | HCC1143 | -4.1759 | 0.9602 | -6.7579 | -6.7479 | -6.8664 | 2.0150 | 0.0235 | 0.0235 | 4.6141 |
| Ispinesib | CAMA-1 | -4.4776 | 0.9764 | -7.5631 | -7.5265 | -7.6633 | 3.6505 | 0.1281 | 0.1281 | 4.6158 |
| Trichostatin A | SUM159PT | -2.3010 | 0.9727 | -5.1850 | -5.1844 | -5.2343 | 1.5990 | 0.0000 | 0.0000 | 4.6160 |
| Ixabepilone | MDA-MB-436 | -4.4045 | 0.8591 | -8.2125 | -7.7702 | -8.2052 | 0.6965 | 0.2540 | 0.2557 | 4.6239 |
| Bortezomib | MCF 10F | -3.7773 | 0.9879 | -6.4513 | -6.4518 | -6.9070 | 0.7522 | 0.0000 | 0.0096 | 4.6275 |
| CGC-11144 | MX1 | -3.1500 | 0.9973 | -5.8730 | -5.8689 | -6.5353 | 0.8389 | 0.0040 | 0.0092 | 4.6340 |
| Vorinostat | SK-BR-3 | -1.7282 | 0.9388 | -4.2237 | -4.2216 | -4.4272 | 1.4870 | 0.0053 | 0.0058 | 4.6385 |
| Bortezomib | SUM1315MO2 | -3.7773 | 0.9821 | -6.5778 | -6.5692 | -7.0549 | 1.1903 | 0.0142 | 0.0178 | 4.6391 |
| GSK461364 | AU565 | -4.4776 | 0.9163 | -7.8996 | -7.8424 | -7.9567 | 3.9990 | 0.1548 | 0.1548 | 4.6399 |
| Vinorelbine | MDA-MB-453 | -4.3335 | 0.9077 | -8.2795 | -8.1921 | -8.3326 | 3.9990 | 0.2760 | 0.2760 | 4.6441 |
| MG-132 | T47D | -4.1759 | 0.9899 | -6.8769 | -6.8733 | -6.9612 | 3.2780 | 0.0132 | 0.0132 | 4.6464 |
| MG-132 | SUM52PE | -4.1759 | 0.9728 | -7.1154 | -7.1007 | -7.1968 | 3.9995 | 0.0630 | 0.0630 | 4.6472 |
| 17-AAG | HCC1954 | -4.0000 | 0.9123 | -7.4570 | -7.2736 | -7.5312 | 2.1480 | 0.1899 | 0.1899 | 4.6514 |
| Vorinostat | HCC38 | -1.7282 | 0.9825 | -4.3132 | -4.3087 | -4.5043 | 1.6240 | 0.0083 | 0.0084 | 4.6555 |
| 17-AAG | MDA-MB-134-VI | -4.0000 | 0.9871 | -7.1850 | -7.1306 | -7.3874 | 2.5250 | 0.1285 | 0.1285 | 4.6601 |
| Trichostatin A | HCC1806 | -2.3010 | 0.9690 | -4.9315 | -4.9267 | -5.0104 | 2.1805 | 0.0119 | 0.0119 | 4.6628 |
| CGC-11144 | SUM229PE | -3.1500 | 0.9824 | -5.7940 | -5.7935 | -6.2524 | 0.8376 | 0.0000 | 0.0069 | 4.6658 |
| Tozasertib | MB 157 | -4.0000 | 0.9915 | -7.0960 | -7.0691 | -7.1271 | 3.7840 | 0.1047 | 0.1047 | 4.6667 |
| 5-FU | HCC1428 | -1.7167 | 0.9024 | -4.7157 | -4.5358 | -5.1729 | 0.9946 | 0.1689 | 0.1698 | 4.6703 |
| Trichostatin A | HCC1569 | -2.3010 | 0.8717 | -4.9980 | -4.9721 | -5.0569 | 2.2065 | 0.0585 | 0.0585 | 4.6730 |
| 17-AAG | SUM229PE | -4.0000 | 0.9060 | -7.4045 | -7.2089 | -7.6089 | 1.1620 | 0.2040 | 0.2040 | 4.6731 |