Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Topotecan | HCC1395 | -3.9626 | 0.9209 | -7.0486 | -6.9981 | -7.7934 | 0.4886 | 0.0366 | 0.0886 | 4.5496 |
| Ixabepilone | SUM1315MO2 | -4.4045 | 0.8868 | -7.9425 | -7.7389 | -8.2229 | 1.6960 | 0.2605 | 0.2605 | 4.5519 |
| Afatinib | UACC-812 | -4.1759 | 0.9313 | -6.8609 | -6.8606 | -8.5554 | 0.4511 | 0.0000 | 0.0579 | 4.5521 |
| Afatinib | SUM225CWN | -4.1759 | 0.9306 | -7.2619 | -7.1185 | -7.9561 | 0.5364 | 0.0814 | 0.1012 | 4.5543 |
| Vinorelbine | SK-BR-3 | -4.3335 | 0.8852 | -7.8995 | -7.8475 | -8.0234 | 3.9960 | 0.1913 | 0.1913 | 4.5547 |
| MG-132 | BT-20 | -4.1759 | 0.8406 | -7.0069 | -6.9822 | -7.2724 | 2.7675 | 0.0756 | 0.0756 | 4.5551 |
| Etoposide | HCC38 | -3.4776 | 0.9946 | -6.3751 | -6.3508 | -6.5517 | 1.4425 | 0.0394 | 0.0396 | 4.5558 |
| Trichostatin A | UACC-893 | -2.3010 | 0.9911 | -5.1235 | -5.1188 | -5.3317 | 2.9500 | 0.0192 | 0.0192 | 4.5560 |
| Trichostatin A | HCC38 | -2.3010 | 0.9816 | -5.1470 | -5.1397 | -5.2478 | 3.0035 | 0.0253 | 0.0253 | 4.5603 |
| Vinorelbine | HCC38 | -4.3335 | 0.9214 | -7.7570 | -7.6518 | -7.9162 | 2.5860 | 0.1921 | 0.1922 | 4.5617 |
| Topotecan | SK-BR-3 | -3.9626 | 0.9775 | -7.2166 | -7.0815 | -7.9071 | 0.9831 | 0.1281 | 0.1324 | 4.5646 |
| Z-Leu-Leu-Norvalinal | MCF12A | -4.1759 | 0.9615 | -6.7609 | -6.7590 | -7.0225 | 1.4930 | 0.0039 | 0.0041 | 4.5658 |
| Ispinesib | SK-BR-3 | -4.4776 | 0.9843 | -7.5416 | -7.5112 | -7.5940 | 3.3705 | 0.1037 | 0.1037 | 4.5686 |
| Trichostatin A | ZR75B | -2.3010 | 0.9827 | -5.1260 | -5.0946 | -5.3275 | 1.1750 | 0.0408 | 0.0413 | 4.5727 |
| Ispinesib | MCF 10A | -4.4776 | 0.9598 | -7.4736 | -7.4230 | -7.4650 | 1.8090 | 0.0891 | 0.0891 | 4.5750 |
| MG-132 | AU565 | -4.1759 | 0.9861 | -6.8929 | -6.8879 | -7.0390 | 2.1840 | 0.0128 | 0.0128 | 4.5793 |
| Ispinesib | SUM159PT | -4.4776 | 0.9664 | -7.4016 | -7.3792 | -7.3990 | 3.9990 | 0.0920 | 0.0920 | 4.5818 |
| Taxol | BT-549 | -4.4776 | 0.9814 | -8.1951 | -8.1066 | -8.1839 | 3.1955 | 0.2355 | 0.2355 | 4.5825 |
| GSK461364 | SUM159PT | -4.4776 | 0.9804 | -7.5366 | -7.5215 | -7.5669 | 3.9990 | 0.0630 | 0.0630 | 4.5877 |
| Docetaxel | HCC38 | -5.0000 | 0.9818 | -8.6120 | -8.4709 | -8.7384 | 1.9535 | 0.2238 | 0.2238 | 4.5902 |
| Trichostatin A | HCC1954 | -2.3010 | 0.9200 | -4.8680 | -4.8614 | -5.0142 | 1.9125 | 0.0223 | 0.0223 | 4.5927 |
| Torkinib | Hs 578T | -4.3010 | 0.8670 | -7.1250 | -7.0821 | -7.3615 | 0.5543 | 0.0264 | 0.0522 | 4.5928 |
| Trichostatin A | MB 157 | -2.3010 | 0.9928 | -4.9680 | -4.9666 | -5.0738 | 1.7480 | 0.0032 | 0.0032 | 4.5977 |
| Bortezomib | MDA-MB-175-VII | -3.7773 | 0.9565 | -7.1443 | -7.0006 | -7.6186 | 1.0930 | 0.1517 | 0.1519 | 4.6032 |
| Omipalisib | MX1 | -4.4776 | 0.9651 | -7.2576 | -7.2341 | -8.2892 | 0.6783 | 0.0178 | 0.0304 | 4.6065 |