Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 1 of 2: GR values. - Dataset (ID:20366)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | AZD8055 | 2 | 72 | 1.0 | 2987.0 | 7167.9 | 2409.0 | 0.0 | 0.146 | 0.417 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | AZD8055 | 3 | 72 | 3.1623 | 2477.0 | 6533.6 | 1943.1 | 0.5 | 0.149 | 0.379 | 1.750 | HCC70 AZD8055 0 3 |
| HCC70 | AZD8055 | 2 | 72 | 1.0 | 3000.0 | 7167.9 | 2409.0 | 0.0 | 0.150 | 0.419 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | QL-VIII-58 | 1 | 72 | 0.3162 | 3131.0 | 7580.8 | 2503.8 | -0.5 | 0.150 | 0.413 | 1.598 | HCC70 QL-VIII-58 0 1 |
| HCC1806 | QL-VIII-58 | 3 | 72 | 1.0 | 3242.0 | 14413.7 | 2222.1 | 0.0 | 0.150 | 0.225 | 2.697 | HCC1806 QL-VIII-58 0 3 |
| HCC1806 | QL-VI-86 | 3 | 72 | 3.1623 | 3243.0 | 14413.7 | 2222.1 | 0.5 | 0.150 | 0.225 | 2.697 | HCC1806 QL-VI-86 0 3 |
| HCC70 | QL-X-138 | 2 | 72 | 3.1623 | 3000.0 | 7167.9 | 2409.0 | 0.5 | 0.150 | 0.419 | 1.573 | HCC70 QL-X-138 0 2 |
| HCC1806 | QL-VI-86 | 3 | 72 | 3.1623 | 3246.0 | 14413.7 | 2222.1 | 0.5 | 0.151 | 0.225 | 2.697 | HCC1806 QL-VI-86 0 3 |
| HCC70 | QL-VIII-58 | 1 | 72 | 0.3162 | 3139.0 | 7580.8 | 2503.8 | -0.5 | 0.152 | 0.414 | 1.598 | HCC70 QL-VIII-58 0 1 |
| HCC1806 | Torin1 | 3 | 72 | 10.0 | 3251.0 | 14413.7 | 2222.1 | 1.0 | 0.152 | 0.226 | 2.697 | HCC1806 Torin1 0 3 |
| HCC1806 | QL-VIII-58 | 2 | 72 | 0.0316 | 4168.0 | 18525.7 | 2822.7 | -1.5 | 0.154 | 0.225 | 2.714 | HCC1806 QL-VIII-58 0 2 |
| HCC70 | Torin2 | 3 | 72 | 0.1 | 2501.0 | 6533.6 | 1943.1 | -1.0 | 0.155 | 0.383 | 1.750 | HCC70 Torin2 0 3 |
| HCC70 | AZD8055 | 1 | 72 | 3.1623 | 3152.0 | 7580.8 | 2503.8 | 0.5 | 0.155 | 0.416 | 1.598 | HCC70 AZD8055 0 1 |
| HCC70 | QL-XII-61 | 3 | 72 | 10.0 | 2503.0 | 6533.6 | 1943.1 | 1.0 | 0.156 | 0.383 | 1.750 | HCC70 QL-XII-61 0 3 |
| HCC70 | QL-XII-108 | 3 | 72 | 10.0 | 2504.0 | 6533.6 | 1943.1 | 1.0 | 0.156 | 0.383 | 1.750 | HCC70 QL-XII-108 0 3 |
| HCC70 | QL-VIII-58 | 1 | 72 | 0.3162 | 3159.0 | 7580.8 | 2503.8 | -0.5 | 0.157 | 0.417 | 1.598 | HCC70 QL-VIII-58 0 1 |
| HCC70 | AZD8055 | 2 | 72 | 0.3162 | 3039.0 | 7167.9 | 2409.0 | -0.5 | 0.159 | 0.424 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | AZD8055 | 1 | 72 | 1.0 | 3171.0 | 7580.8 | 2503.8 | 0.0 | 0.159 | 0.418 | 1.598 | HCC70 AZD8055 0 1 |
| HCC70 | QL-XII-47 | 3 | 72 | 1.0 | 2517.0 | 6533.6 | 1943.1 | 0.0 | 0.159 | 0.385 | 1.750 | HCC70 QL-XII-47 0 3 |
| HCC1806 | QL-VI-86 | 1 | 72 | 3.1623 | 4268.0 | 17793.8 | 2895.7 | 0.5 | 0.160 | 0.240 | 2.619 | HCC1806 QL-VI-86 0 1 |
| HCC1806 | Torin1 | 1 | 72 | 10.0 | 4292.0 | 17793.8 | 2895.7 | 1.0 | 0.162 | 0.241 | 2.619 | HCC1806 Torin1 0 1 |
| HCC1806 | Torin1 | 3 | 72 | 10.0 | 3331.0 | 14413.7 | 2222.1 | 1.0 | 0.162 | 0.231 | 2.697 | HCC1806 Torin1 0 3 |
| HCC70 | QL-XII-47 | 3 | 72 | 1.0 | 2529.0 | 6533.6 | 1943.1 | 0.0 | 0.163 | 0.387 | 1.750 | HCC70 QL-XII-47 0 3 |
| HCC70 | Torin1 | 3 | 72 | 1.0 | 2540.0 | 6533.6 | 1943.1 | 0.0 | 0.165 | 0.389 | 1.750 | HCC70 Torin1 0 3 |
| HCC1806 | Torin1 | 2 | 72 | 10.0 | 4279.0 | 18525.7 | 2822.7 | 1.0 | 0.166 | 0.231 | 2.714 | HCC1806 Torin1 0 2 |