Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 1 of 2: GR values. - Dataset (ID:20366)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | QL-XII-47 | 2 | 72 | 1.0 | 3780.0 | 18525.7 | 2822.7 | 0.0 | 0.114 | 0.204 | 2.714 | HCC1806 QL-XII-47 0 2 |
| HCC70 | AZD8055 | 1 | 72 | 1.0 | 2978.0 | 7580.8 | 2503.8 | 0.0 | 0.115 | 0.393 | 1.598 | HCC70 AZD8055 0 1 |
| HCC70 | QL-V-107 | 2 | 72 | 0.3162 | 2862.0 | 7167.9 | 2409.0 | -0.5 | 0.116 | 0.399 | 1.573 | HCC70 QL-V-107 0 2 |
| HCC70 | Torin1 | 1 | 72 | 1.0 | 2997.0 | 7580.8 | 2503.8 | 0.0 | 0.119 | 0.395 | 1.598 | HCC70 Torin1 0 1 |
| HCC1806 | QL-VI-86 | 3 | 72 | 3.1623 | 3018.0 | 14413.7 | 2222.1 | 0.5 | 0.120 | 0.209 | 2.697 | HCC1806 QL-VI-86 0 3 |
| HCC70 | AZD8055 | 2 | 72 | 1.0 | 2886.0 | 7167.9 | 2409.0 | 0.0 | 0.122 | 0.403 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | QL-VI-86 | 2 | 72 | 1.0 | 2887.0 | 7167.9 | 2409.0 | 0.0 | 0.122 | 0.403 | 1.573 | HCC70 QL-VI-86 0 2 |
| HCC70 | AZD8055 | 1 | 72 | 3.1623 | 3011.0 | 7580.8 | 2503.8 | 0.5 | 0.122 | 0.397 | 1.598 | HCC70 AZD8055 0 1 |
| HCC70 | Torin1 | 2 | 72 | 0.3162 | 2892.0 | 7167.9 | 2409.0 | -0.5 | 0.123 | 0.403 | 1.573 | HCC70 Torin1 0 2 |
| HCC70 | AZD8055 | 3 | 72 | 3.1623 | 2404.0 | 6533.6 | 1943.1 | 0.5 | 0.129 | 0.368 | 1.750 | HCC70 AZD8055 0 3 |
| HCC70 | QL-VIII-58 | 2 | 72 | 0.3162 | 2921.0 | 7167.9 | 2409.0 | -0.5 | 0.130 | 0.408 | 1.573 | HCC70 QL-VIII-58 0 2 |
| HCC70 | Torin1 | 2 | 72 | 0.3162 | 2919.0 | 7167.9 | 2409.0 | -0.5 | 0.130 | 0.407 | 1.573 | HCC70 Torin1 0 2 |
| HCC70 | AZD8055 | 2 | 72 | 0.3162 | 2928.0 | 7167.9 | 2409.0 | -0.5 | 0.132 | 0.408 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | QL-XII-61 | 3 | 72 | 10.0 | 2414.0 | 6533.6 | 1943.1 | 1.0 | 0.132 | 0.369 | 1.750 | HCC70 QL-XII-61 0 3 |
| HCC1806 | QL-VI-86 | 1 | 72 | 3.1623 | 4005.0 | 17793.8 | 2895.7 | 0.5 | 0.132 | 0.225 | 2.619 | HCC1806 QL-VI-86 0 1 |
| HCC70 | Torin1 | 3 | 72 | 1.0 | 2417.0 | 6533.6 | 1943.1 | 0.0 | 0.133 | 0.370 | 1.750 | HCC70 Torin1 0 3 |
| HCC70 | QL-XII-47 | 2 | 72 | 1.0 | 2930.0 | 7167.9 | 2409.0 | 0.0 | 0.133 | 0.409 | 1.573 | HCC70 QL-XII-47 0 2 |
| HCC70 | QL-XII-108 | 1 | 72 | 10.0 | 3071.0 | 7580.8 | 2503.8 | 1.0 | 0.136 | 0.405 | 1.598 | HCC70 QL-XII-108 0 1 |
| HCC70 | QL-VIII-58 | 2 | 72 | 0.3162 | 2963.0 | 7167.9 | 2409.0 | -0.5 | 0.141 | 0.413 | 1.573 | HCC70 QL-VIII-58 0 2 |
| HCC70 | AZD8055 | 3 | 72 | 3.1623 | 2446.0 | 6533.6 | 1943.1 | 0.5 | 0.141 | 0.374 | 1.750 | HCC70 AZD8055 0 3 |
| HCC70 | QL-XII-47 | 3 | 72 | 1.0 | 2447.0 | 6533.6 | 1943.1 | 0.0 | 0.141 | 0.375 | 1.750 | HCC70 QL-XII-47 0 3 |
| HCC70 | AZD8055 | 2 | 72 | 0.3162 | 2968.0 | 7167.9 | 2409.0 | -0.5 | 0.142 | 0.414 | 1.573 | HCC70 AZD8055 0 2 |
| HCC70 | AZD8055 | 1 | 72 | 3.1623 | 3106.0 | 7580.8 | 2503.8 | 0.5 | 0.144 | 0.410 | 1.598 | HCC70 AZD8055 0 1 |
| HCC70 | QL-XII-108 | 3 | 72 | 10.0 | 2459.0 | 6533.6 | 1943.1 | 1.0 | 0.144 | 0.376 | 1.750 | HCC70 QL-XII-108 0 3 |
| HCC70 | QL-VI-86 | 1 | 72 | 1.0 | 3111.0 | 7580.8 | 2503.8 | 0.0 | 0.146 | 0.410 | 1.598 | HCC70 QL-VI-86 0 1 |