Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 1 72 | 8 | 1.798 | 27.5 | 0.671 | 0.115 | 4.1 | 0.299 | 0.478 | 0.992 | 4.23e-07 | NA | 164.0 | 0.723 | 0.901 | 4.18 | 0.408 | 0.461 | 0.992 | 5.34e-07 | NA |
HCC1806 | AZD-6482 | 3 | 72 | flat | flat | HCC1806 AZD6482 0 3 72 | 8 | 3.201 | Inf | 1.0 | 0.00122 | 0.0 | 1.0 | 0.01 | -0.0063 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
HCC70 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD6482 0 3 72 | 8 | 2.532 | 1.43 | 0.435 | 0.247 | 0.421 | 0.226 | 0.492 | 0.983 | 4.63e-06 | NA | 1.13 | 0.431 | 0.729 | 0.208 | 0.286 | 0.5 | 0.982 | 6.2e-06 | NA |
BT-20 | AZD-6482 | 2 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 2 72 | 8 | 1.645 | 0.581 | 0.0253 | 0.303 | 3.86 | -1.0 | 0.58 | 0.904 | 0.000884 | NA | 1.34 | 0.333 | 0.772 | 1.34 | 0.0 | 0.582 | 0.864 | 0.0025 | NA |
HCC1806 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 2 72 | 8 | 2.817 | Inf | 0.546 | 0.24 | 0.0517 | 0.535 | 1.19 | 0.995 | 1.31e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 3 72 | 8 | 3.185 | Inf | 0.593 | 0.215 | 0.0523 | 0.583 | 1.19 | 0.995 | 1.36e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 1 72 | 8 | 2.732 | Inf | 0.534 | 0.247 | 0.0515 | 0.522 | 1.19 | 0.995 | 1.3e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC70 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 2 72 | 8 | 1.724 | 0.17 | 0.404 | 0.346 | 0.0331 | 0.385 | 0.897 | 0.996 | 7.36e-08 | NA | Inf | 0.543 | 0.728 | 0.0284 | 0.531 | 0.905 | 0.996 | 6.22e-08 | NA |
HCC70 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 3 72 | 8 | 2.442 | Inf | 0.571 | 0.287 | 0.0133 | 0.574 | 1.17 | 0.98 | 8.55e-06 | NA | Inf | 0.554 | 0.694 | 0.0116 | 0.556 | 1.17 | 0.974 | 1.69e-05 | NA |
HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |
BT-20 | AZD8055 | 1 | 72 | sigmoid | sigmoid | BT20 AZD8055 0 1 72 | 8 | 2.117 | 0.0548 | 0.243 | 0.465 | 0.0266 | 0.213 | 0.768 | 0.984 | 4.08e-06 | NA | 0.0937 | 0.365 | 0.589 | 0.0198 | 0.335 | 0.713 | 0.982 | 5.4e-06 | NA |
HCC38 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 2 72 | 8 | 2.128 | 0.0616 | 0.16 | 0.467 | 0.045 | 0.124 | 0.912 | 0.993 | 3.13e-07 | NA | 0.0875 | 0.314 | 0.594 | 0.0332 | 0.284 | 0.869 | 0.991 | 6.5e-07 | NA |
BT-20 | AZD8055 | 2 | 72 | sigmoid | sigmoid | BT20 AZD8055 0 2 72 | 8 | 1.951 | 0.00909 | 0.155 | 0.651 | 0.00651 | 0.115 | 0.785 | 0.936 | 0.000258 | NA | 0.0185 | 0.343 | 0.477 | 0.00469 | 0.311 | 0.706 | 0.934 | 0.000289 | NA |
HCC70 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 1 72 | 8 | 1.339 | 0.0485 | 0.242 | 0.442 | 0.0243 | 0.26 | 1.06 | 0.976 | 1.32e-05 | NA | Inf | 0.529 | 0.721 | 0.0222 | 0.54 | 1.08 | 0.974 | 1.81e-05 | NA |
HCC38 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 1 72 | 8 | 1.773 | 0.052 | 0.151 | 0.479 | 0.0381 | 0.136 | 1.02 | 0.992 | 4.28e-07 | NA | 0.116 | 0.375 | 0.633 | 0.0313 | 0.363 | 0.987 | 0.993 | 3.89e-07 | NA |
Hs 578T | AZD8055 | 3 | sigmoid | sigmoid | Hs578T AZD8055 3 | 8 | 2.886 | 0.0538 | 0.232 | 0.451 | 0.0311 | 0.22 | 1.06 | 0.995 | 1.13e-07 | NA | 0.039 | 0.247 | 0.521 | 0.0208 | 0.231 | 0.989 | 0.995 | 1.55e-07 | NA | |
Hs 578T | AZD8055 | 2 | sigmoid | sigmoid | Hs578T AZD8055 2 | 8 | 2.480 | 0.0521 | 0.149 | 0.469 | 0.0387 | 0.142 | 1.13 | 0.999 | 3.49e-10 | NA | 0.0495 | 0.253 | 0.557 | 0.0273 | 0.249 | 1.16 | 0.999 | 4.45e-10 | NA | |
Hs 578T | AZD8055 | 1 | sigmoid | sigmoid | Hs578T AZD8055 1 | 8 | 2.009 | 0.0391 | 0.073 | 0.531 | 0.0347 | 0.0546 | 0.975 | 0.995 | 1.39e-07 | NA | 0.0591 | 0.286 | 0.565 | 0.0259 | 0.27 | 0.941 | 0.994 | 1.73e-07 | NA | |
BT-20 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT20 AZD8055 0 3 72 | 8 | 2.694 | 0.0351 | 0.345 | 0.472 | 0.0116 | 0.313 | 0.89 | 0.934 | 0.000286 | NA | 0.0291 | 0.343 | 0.506 | 0.00813 | 0.306 | 0.743 | 0.922 | 0.000471 | NA |
BT-549 | AZD8055 | 2 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 2 72 | 8 | 1.848 | 0.0373 | 0.14 | 0.506 | 0.0287 | 0.138 | 1.23 | 0.994 | 2.1e-07 | NA | 0.0653 | 0.354 | 0.605 | 0.0239 | 0.35 | 1.2 | 0.995 | 1.39e-07 | NA |
BT-549 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 3 72 | 8 | 1.757 | 0.0178 | 0.159 | 0.59 | 0.0122 | 0.145 | 0.913 | 0.942 | 0.000193 | NA | 0.0479 | 0.383 | 0.555 | 0.00973 | 0.372 | 0.854 | 0.954 | 9.74e-05 | NA |
BT-549 | AZD8055 | 1 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 1 72 | 8 | 1.781 | 0.0305 | 0.165 | 0.526 | 0.0228 | 0.14 | 1.13 | 0.992 | 4.7e-07 | NA | 0.0615 | 0.382 | 0.599 | 0.0189 | 0.367 | 1.12 | 0.994 | 1.9e-07 | NA |
BT-549 | Buparlisib | 1 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 1 72 | 8 | 1.837 | 0.729 | -0.325 | 0.253 | 1.83 | -1.0 | 1.19 | 0.994 | 2.4e-07 | NA | 0.926 | 0.136 | 0.807 | 0.926 | 0.0 | 1.37 | 0.987 | 2.46e-06 | NA |
BT-549 | Buparlisib | 2 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 2 72 | 8 | 1.913 | 0.681 | -0.306 | 0.217 | 1.08 | -0.538 | 1.59 | 0.998 | 1.31e-08 | NA | 0.821 | 0.132 | 0.838 | 0.769 | 0.0514 | 1.66 | 0.996 | 8.95e-08 | NA |
HCC38 | Buparlisib | 1 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 1 72 | 8 | 1.738 | 0.912 | -0.226 | 0.194 | 1.46 | -0.57 | 1.62 | 0.999 | 9.48e-10 | NA | 1.2 | 0.192 | 0.858 | 1.12 | 0.0495 | 1.66 | 0.998 | 4.36e-09 | NA |