Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC38	AS605240	3	72	flat	flat	HCC38 AS-605240 0 3 72	8	1.343	Inf	0.958	-0.0162	0.0	0.958	0.01	-0.233	1.0	1.01	Inf	0.972	1.01	0.0	0.972	0.01	-0.235	1.0	1.01
HCC1806	AS605240	3	72	sigmoid	sigmoid	HCC1806 AS-605240 0 3 72	8	3.181	Inf	0.923	0.011	0.57	0.923	2.81	0.936	0.000257	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
BT-549	AS605240	3	72	sigmoid	sigmoid	BT549 AS-605240 0 3 72	8	1.796	Inf	0.863	0.066	4.3	0.721	0.307	0.896	0.00112	NA	Inf	0.881	0.942	4.35	0.756	0.302	0.894	0.00118	NA
HCC1806	AS605240	1	72	sigmoid	sigmoid	HCC1806 AS-605240 0 1 72	8	2.728	Inf	0.911	0.0128	0.569	0.91	2.8	0.936	0.000262	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC70	AS605240	1	72	sigmoid	sigmoid	HCC70 AS-605240 0 1 72	8	1.387	10.4	0.487	0.159	0.247	0.497	1.34	0.963	5.14e-05	NA	Inf	0.663	0.894	0.23	0.672	1.39	0.961	6.01e-05	NA
HCC70	AS605240	3	72	sigmoid	sigmoid	HCC70 AS-605240 0 3 72	8	2.447	Inf	0.58	0.112	0.427	0.549	1.18	0.985	3.24e-06	NA	Inf	0.562	0.877	0.345	0.544	1.24	0.982	6.14e-06	NA
HCC70	AS605240	2	72	sigmoid	sigmoid	HCC70 AS-605240 0 2 72	8	1.771	6.13	0.558	0.126	1.21	0.339	0.698	0.981	7.24e-06	NA	785.0	0.643	0.894	0.946	0.496	0.708	0.978	1.04e-05	NA
BT-20	AS605240	2	72	sigmoid	sigmoid	BT20 AS-605240 0 2 72	8	1.846	4509270.0	0.729	0.203	320.0	0.31	0.101	0.845	0.00373	NA	4.4e+12	0.764	0.821	56.5	0.46	0.101	0.843	0.00388	NA
HCC38	AS605240	2	72	sigmoid	sigmoid	HCC38 AS-605240 0 2 72	8	2.200	17.4	0.642	0.114	4.07	0.256	0.493	0.936	0.000265	NA	46.2	0.648	0.882	1.68	0.411	0.522	0.929	0.000356	NA
Hs 578T	AS605240	1		sigmoid	sigmoid	Hs578T AS-605240 1	8	2.015	0.758	0.341	0.212	0.333	0.265	0.921	0.991	7.83e-07	NA	1.42	0.447	0.811	0.246	0.408	0.964	0.989	1.51e-06	NA
BT-549	AZD-6482	3	72	sigmoid	sigmoid	BT549 AZD6482 0 3 72	8	1.744	8.87	0.616	0.0979	2.2	0.324	0.749	0.993	2.93e-07	NA	115.0	0.69	0.918	1.91	0.476	0.744	0.993	4.19e-07	NA
BT-20	AZD-6482	3	72	sigmoid	sigmoid	BT20 AZD6482 0 3 72	8	2.601	1.68	0.3	0.173	8.38	-1.0	0.685	0.959	6.72e-05	NA	1.5	0.326	0.805	1.5	0.0	0.733	0.925	0.000414	NA
Hs 578T	AZD-6482	2		sigmoid	sigmoid	Hs578T AZD6482 2	8	2.508	6.35	0.602	0.121	74.8	-1.0	0.445	0.998	1.12e-08	NA	6.4	0.573	0.86	6.4	0.0	0.475	0.996	6.36e-08	NA
Hs 578T	AZD-6482	1		sigmoid	sigmoid	Hs578T AZD6482 1	8	2.041	2.04	0.401	0.177	18.5	-1.0	0.498	0.986	2.92e-06	NA	3.16	0.484	0.835	3.16	0.0	0.532	0.98	7.93e-06	NA
BT-20	AZD-6482	1	72	sigmoid	sigmoid	BT20 AZD6482 0 1 72	8	2.043	1.34	0.182	0.173	3.83	-0.782	0.893	0.982	5.6e-06	NA	1.65	0.342	0.845	1.65	0.0	0.977	0.972	2.09e-05	NA
HCC1806	AZD-6482	1	72	flat	flat	HCC1806 AZD6482 0 1 72	8	2.748	Inf	1.0	0.00141	0.0	1.0	0.01	-0.00621	1.0	0.999	Inf	1.01	0.998	0.0	1.01	0.01	-0.00515	1.0	0.998
BT-549	AZD-6482	2	72	sigmoid	sigmoid	BT549 AZD6482 0 2 72	8	1.973	9.15	0.635	0.112	120.0	-1.0	0.426	0.951	0.000115	NA	19.4	0.672	0.895	19.4	0.0	0.437	0.946	0.000154	NA
HCC70	AZD-6482	1	72	sigmoid	sigmoid	HCC70 AZD6482 0 1 72	8	1.368	0.0982	0.0128	0.462	0.205	-0.212	0.481	0.975	1.49e-05	NA	0.767	0.394	0.704	0.121	0.305	0.509	0.973	1.9e-05	NA
HCC38	AZD-6482	1	72	sigmoid	sigmoid	HCC38 AZD6482 0 1 72	8	1.732	Inf	0.862	0.0239	1.4	0.804	1.03	0.909	0.000761	NA	Inf	0.883	0.98	1.34	0.837	1.03	0.904	0.000873	NA
HCC38	AZD-6482	2	72	sigmoid	sigmoid	HCC38 AZD6482 0 2 72	8	2.132	Inf	0.898	0.0351	4.71	0.773	0.497	0.824	0.0055	NA	Inf	0.894	0.963	4.7	0.765	0.492	0.82	0.00588	NA
HCC70	AZD-6482	2	72	sigmoid	sigmoid	HCC70 AZD6482 0 2 72	8	1.772	0.267	0.256	0.366	0.237	0.0255	0.43	0.987	2.27e-06	NA	1.16	0.438	0.706	0.133	0.306	0.437	0.986	3.03e-06	NA
HCC70	AZD-6482	3	72	sigmoid	sigmoid	HCC70 AZD6482 0 3 72	8	2.532	1.43	0.435	0.247	0.421	0.226	0.492	0.983	4.63e-06	NA	1.13	0.431	0.729	0.208	0.286	0.5	0.982	6.2e-06	NA
HCC1806	AZD-6482	2	72	flat	flat	HCC1806 AZD6482 0 2 72	8	2.833	Inf	1.0	0.00136	0.0	1.0	0.01	-0.0062	1.0	0.999	Inf	1.01	0.998	0.0	1.01	0.01	-0.00512	1.0	0.998
BT-20	AZD-6482	2	72	sigmoid	sigmoid	BT20 AZD6482 0 2 72	8	1.645	0.581	0.0253	0.303	3.86	-1.0	0.58	0.904	0.000884	NA	1.34	0.333	0.772	1.34	0.0	0.582	0.864	0.0025	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)