Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
HCC1806 ZSTK474 3 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 3 72
 8 3.162
Inf
0.654
0.0322
1.18
0.65
4.68
0.99
1.03e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 2 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 2 72
 8 2.794
Inf
0.613
0.036
1.16
0.61
5.0
0.99
1.1e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
BT-20 ZSTK474 2 72
sigmoid
sigmoid
BT20 ZSTK474 0 2 72
 8 1.787
0.286
-0.19
0.347
0.373
-0.234
1.46
0.992
4.53e-07
NA
0.391
0.199
0.743
0.29
0.184
1.55
0.988
1.84e-06
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA