Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
Download: Excel (XLSX), Comma-separated (CSV)
Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BT-549 | PI103 | 1 | 72 | sigmoid | sigmoid | BT549 PI-103 0 1 72 | 8 | 1.795 | 0.206 | 0.0898 | 0.34 | 0.185 | 0.0628 | 1.25 | 0.997 | 2.96e-08 | NA | 0.348 | 0.336 | 0.737 | 0.155 | 0.318 | 1.25 | 0.996 | 8.76e-08 | NA |
BT-549 | PI103 | 2 | 72 | sigmoid | sigmoid | BT549 PI-103 0 2 72 | 8 | 1.893 | 0.218 | 0.0201 | 0.344 | 0.229 | -0.0262 | 1.08 | 0.997 | 2.55e-08 | NA | 0.326 | 0.28 | 0.725 | 0.169 | 0.261 | 1.13 | 0.996 | 6.2e-08 | NA |
HCC38 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 2 72 | 8 | 2.112 | Inf | 0.622 | 0.0838 | 0.644 | 0.58 | 1.32 | 0.933 | 0.000298 | NA | Inf | 0.642 | 0.918 | 0.568 | 0.612 | 1.36 | 0.922 | 0.000475 | NA |
HCC38 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 3 72 | 8 | 1.420 | 3.12 | 0.499 | 0.129 | 2.45 | 0.0818 | 0.738 | 0.976 | 1.33e-05 | NA | 20.5 | 0.664 | 0.911 | 2.24 | 0.401 | 0.731 | 0.974 | 1.7e-05 | NA |
BT-20 | Pictilisib | 2 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 2 72 | 8 | 1.746 | 0.308 | -0.0521 | 0.379 | 2.35 | -1.0 | 0.54 | 0.791 | 0.00908 | NA | 0.634 | 0.272 | 0.712 | 0.634 | 0.0 | 0.6 | 0.716 | 0.0229 | NA |
BT-20 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 1 72 | 8 | 2.085 | 1.25 | 0.163 | 0.177 | 5.0 | -1.0 | 0.791 | 0.994 | 1.75e-07 | NA | 1.52 | 0.323 | 0.838 | 1.52 | 0.0 | 0.865 | 0.989 | 1.22e-06 | NA |
HCC1806 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 3 72 | 8 | 3.234 | 14.1 | 0.818 | 0.0423 | 52.2 | -0.98 | 0.831 | 0.814 | 0.00649 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
HCC1806 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 2 72 | 8 | 2.866 | 12.1 | 0.796 | 0.0476 | 45.4 | -1.0 | 0.831 | 0.811 | 0.00671 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
HCC1806 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 1 72 | 8 | 2.782 | 11.7 | 0.79 | 0.049 | 43.7 | -1.0 | 0.831 | 0.811 | 0.00677 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
BT-549 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 1 72 | 8 | 1.772 | 2.08 | 0.415 | 0.117 | 1.42 | 0.154 | 0.959 | 0.987 | 2.26e-06 | NA | 5.12 | 0.541 | 0.904 | 1.06 | 0.396 | 0.995 | 0.985 | 3.49e-06 | NA |
BT-549 | Pictilisib | 2 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 2 72 | 8 | 1.960 | 1.84 | 0.365 | 0.166 | 11.5 | -1.0 | 0.599 | 0.943 | 0.000187 | NA | 2.82 | 0.473 | 0.851 | 2.82 | 0.0 | 0.647 | 0.924 | 0.000432 | NA |
BT-549 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 3 72 | 8 | 1.767 | 1.42 | 0.276 | 0.169 | 4.62 | -0.67 | 0.722 | 0.998 | 9.61e-09 | NA | 2.47 | 0.452 | 0.863 | 2.47 | 0.0 | 0.742 | 0.997 | 2.13e-08 | NA |
HCC70 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 2 72 | 8 | 1.783 | 0.811 | 0.124 | 0.189 | 0.858 | -0.0372 | 1.27 | 0.973 | 2.08e-05 | NA | 1.25 | 0.358 | 0.852 | 0.678 | 0.278 | 1.32 | 0.963 | 5.09e-05 | NA |
HCC70 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 3 72 | 8 | 2.450 | 1.32 | 0.305 | 0.102 | 0.938 | 0.225 | 1.76 | 0.983 | 4.73e-06 | NA | 1.28 | 0.351 | 0.901 | 0.766 | 0.303 | 1.81 | 0.973 | 2.06e-05 | NA |
Hs 578T | Pictilisib | 2 | sigmoid | sigmoid | Hs578T pictilisib 2 | 8 | 2.512 | 1.93 | 0.45 | 0.194 | 0.4 | 0.333 | 0.696 | 0.98 | 8e-06 | NA | 1.58 | 0.446 | 0.787 | 0.231 | 0.381 | 0.746 | 0.974 | 1.74e-05 | NA | |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA | |
Hs 578T | Pictilisib | 1 | sigmoid | sigmoid | Hs578T pictilisib 1 | 8 | 2.048 | 0.482 | 0.341 | 0.267 | 0.162 | 0.295 | 0.819 | 0.998 | 8.97e-09 | NA | 0.981 | 0.441 | 0.759 | 0.12 | 0.416 | 0.847 | 0.998 | 6.97e-09 | NA | |
HCC70 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 1 72 | 8 | 1.409 | 0.408 | -0.099 | 0.284 | 0.578 | -0.245 | 1.14 | 0.996 | 7.62e-08 | NA | 0.888 | 0.325 | 0.816 | 0.477 | 0.261 | 1.19 | 0.995 | 1.2e-07 | NA |
BT-20 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 3 72 | 8 | 2.566 | 0.839 | 0.172 | 0.22 | 0.914 | -0.0483 | 1.09 | 0.954 | 9.59e-05 | NA | 0.843 | 0.254 | 0.768 | 0.809 | 0.0179 | 0.898 | 0.918 | 0.000551 | NA |
HCC38 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 1 72 | 8 | 1.759 | 7.16 | 0.562 | 0.125 | 1.04 | 0.377 | 0.725 | 0.992 | 5.12e-07 | NA | Inf | 0.647 | 0.896 | 0.797 | 0.529 | 0.742 | 0.992 | 5.77e-07 | NA |
BT-20 | PIK-93 | 1 | 72 | sigmoid | sigmoid | BT20 PIK-93 0 1 72 | 8 | 2.025 | 2.65 | 0.406 | 0.0864 | 6.54 | -1.0 | 1.22 | 0.993 | 3.89e-07 | NA | 3.15 | 0.49 | 0.92 | 3.15 | 0.0 | 1.31 | 0.989 | 1.33e-06 | NA |
BT-549 | PIK-93 | 3 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 3 72 | 8 | 1.807 | 20.1 | 0.719 | 0.0848 | 231.0 | -1.0 | 0.45 | 0.716 | 0.0229 | NA | 67.9 | 0.761 | 0.925 | 67.9 | 0.0 | 0.431 | 0.686 | 0.0309 | NA |
Hs 578T | PIK-93 | 1 | sigmoid | sigmoid | Hs578T PIK-93 1 | 8 | 2.033 | 1.44 | 0.276 | 0.175 | 8.38 | -1.0 | 0.624 | 0.991 | 6.57e-07 | NA | 2.0 | 0.401 | 0.84 | 2.0 | 0.0 | 0.672 | 0.99 | 9.72e-07 | NA | |
Hs 578T | PIK-93 | 2 | sigmoid | sigmoid | Hs578T PIK-93 2 | 8 | 2.467 | 2.43 | 0.415 | 0.0931 | 3.62 | -0.243 | 0.991 | 0.991 | 8.05e-07 | NA | 2.34 | 0.426 | 0.901 | 1.93 | 0.0909 | 1.04 | 0.987 | 2.24e-06 | NA | |
Hs 578T | PIK-93 | 3 | sigmoid | sigmoid | Hs578T PIK-93 3 | 8 | 2.816 | 2.36 | 0.412 | 0.0884 | 2.23 | 0.033 | 1.2 | 0.994 | 1.87e-07 | NA | 1.89 | 0.375 | 0.897 | 1.42 | 0.149 | 1.24 | 0.991 | 8.33e-07 | NA |