Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | Alpelisib | 3 | sigmoid | sigmoid | Hs578T alpelisib 3 | 8 | 2.856 | Inf | 0.712 | 0.0759 | 0.872 | 0.616 | 0.828 | 0.963 | 5.21e-05 | NA | Inf | 0.641 | 0.901 | 0.65 | 0.553 | 0.853 | 0.955 | 8.85e-05 | NA | |
BT-20 | Alpelisib | 2 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 2 72 | 8 | 1.692 | 0.253 | -0.0994 | 0.405 | 2.25 | -1.0 | 0.503 | 0.835 | 0.00451 | NA | 0.612 | 0.259 | 0.698 | 0.612 | 0.0 | 0.507 | 0.764 | 0.0131 | NA |
HCC1806 | Alpelisib | 1 | 72 | flat | flat | HCC1806 alpelisib 0 1 72 | 8 | 2.771 | Inf | 0.918 | 0.0583 | 0.0 | 0.918 | 0.01 | -0.337 | 1.0 | 0.94 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
Hs 578T | Alpelisib | 2 | flat | flat | Hs578T alpelisib 2 | 8 | 2.513 | Inf | 0.668 | 0.131 | 0.0 | 0.668 | 0.01 | 0.599 | 0.0647 | 0.856 | Inf | 0.634 | 0.847 | 0.0 | 0.634 | 0.01 | 0.541 | 0.0969 | 0.833 | |
HCC1806 | Alpelisib | 2 | 72 | flat | flat | HCC1806 alpelisib 0 2 72 | 8 | 2.856 | Inf | 0.921 | 0.0566 | 0.0 | 0.921 | 0.01 | -0.336 | 1.0 | 0.941 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
BT-20 | Alpelisib | 3 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 3 72 | 8 | 2.541 | 1.21 | 0.199 | 0.21 | 5.83 | -1.0 | 0.697 | 0.881 | 0.00167 | NA | 1.12 | 0.272 | 0.775 | 1.12 | 0.0 | 0.764 | 0.791 | 0.00916 | NA |
HCC38 | Alpelisib | 3 | 72 | flat | flat | HCC38 alpelisib 0 3 72 | 8 | 1.398 | Inf | 0.75 | 0.0995 | 0.0 | 0.75 | 0.01 | 0.141 | 0.634 | 0.883 | Inf | 0.829 | 0.932 | 0.0 | 0.829 | 0.01 | 0.113 | 0.698 | 0.92 |
HCC70 | Alpelisib | 2 | 72 | flat | flat | HCC70 alpelisib 0 2 72 | 8 | 1.799 | Inf | 0.748 | 0.0777 | 0.0 | 0.748 | 0.01 | 0.00864 | 0.974 | 0.907 | Inf | 0.785 | 0.932 | 0.0 | 0.785 | 0.01 | 0.00534 | 0.984 | 0.919 |
HCC38 | Alpelisib | 2 | 72 | flat | flat | HCC38 alpelisib 0 2 72 | 8 | 2.086 | Inf | 0.848 | 0.0559 | 0.0 | 0.848 | 0.01 | -0.0371 | 1.0 | 0.931 | Inf | 0.848 | 0.944 | 0.0 | 0.848 | 0.01 | -0.0359 | 1.0 | 0.932 |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
BT-549 | Alpelisib | 2 | 72 | sigmoid | sigmoid | BT549 alpelisib 0 2 72 | 8 | 1.927 | Inf | 0.832 | 0.0409 | 4.24 | 0.663 | 0.548 | 0.706 | 0.0254 | NA | Inf | 0.844 | 0.962 | 4.26 | 0.686 | 0.542 | 0.696 | 0.0282 | NA |
HCC1806 | Alpelisib | 3 | 72 | flat | flat | HCC1806 alpelisib 0 3 72 | 8 | 3.224 | Inf | 0.93 | 0.0502 | 0.0 | 0.93 | 0.01 | -0.335 | 1.0 | 0.948 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
BT-549 | Alpelisib | 1 | 72 | flat | flat | BT549 alpelisib 0 1 72 | 8 | 1.822 | Inf | 0.747 | 0.0781 | 0.0 | 0.747 | 0.01 | 0.439 | 0.176 | 0.914 | Inf | 0.782 | 0.931 | 0.0 | 0.782 | 0.01 | 0.415 | 0.2 | 0.925 |
HCC70 | Alpelisib | 1 | 72 | sigmoid | sigmoid | HCC70 alpelisib 0 1 72 | 8 | 1.383 | 4.4 | 0.574 | 0.105 | 20.4 | -1.0 | 0.717 | 0.78 | 0.0106 | NA | 11.9 | 0.718 | 0.929 | 11.9 | 0.0 | 0.732 | 0.768 | 0.0124 | NA |
BT-549 | Alpelisib | 3 | 72 | flat | flat | BT549 alpelisib 0 3 72 | 8 | 1.743 | Inf | 0.817 | 0.068 | 0.0 | 0.817 | 0.01 | -0.0192 | 1.0 | 0.915 | Inf | 0.846 | 0.942 | 0.0 | 0.846 | 0.01 | -0.0162 | 1.0 | 0.928 |
HCC38 | Alpelisib | 1 | 72 | flat | flat | HCC38 alpelisib 0 1 72 | 8 | 1.738 | Inf | 0.757 | 0.0835 | 0.0 | 0.757 | 0.01 | 0.593 | 0.0674 | 0.909 | Inf | 0.798 | 0.929 | 0.0 | 0.798 | 0.01 | 0.579 | 0.0744 | 0.923 |
HCC70 | Alpelisib | 3 | 72 | flat | flat | HCC70 alpelisib 0 3 72 | 8 | 2.465 | Inf | 0.859 | 0.027 | 0.0 | 0.859 | 0.01 | 0.407 | 0.209 | 0.961 | Inf | 0.835 | 0.968 | 0.0 | 0.835 | 0.01 | 0.394 | 0.222 | 0.954 |
BT-20 | Alpelisib | 1 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 1 72 | 8 | 2.077 | 1.14 | 0.046 | 0.196 | 3.52 | -1.0 | 0.977 | 0.966 | 4.1e-05 | NA | 1.32 | 0.26 | 0.825 | 1.32 | 0.0 | 1.13 | 0.942 | 0.000194 | NA |
HCC70 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 3 72 | 8 | 2.447 | Inf | 0.58 | 0.112 | 0.427 | 0.549 | 1.18 | 0.985 | 3.24e-06 | NA | Inf | 0.562 | 0.877 | 0.345 | 0.544 | 1.24 | 0.982 | 6.14e-06 | NA |
BT-549 | AS605240 | 2 | 72 | flat | flat | BT549 AS-605240 0 2 72 | 8 | 1.961 | Inf | 0.91 | 0.0479 | 0.0 | 0.91 | 0.01 | 0.414 | 0.201 | 0.949 | Inf | 0.914 | 0.954 | 0.0 | 0.914 | 0.01 | 0.418 | 0.197 | 0.951 |
HCC1806 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC1806 AS-605240 0 1 72 | 8 | 2.728 | Inf | 0.911 | 0.0128 | 0.569 | 0.91 | 2.8 | 0.936 | 0.000262 | NA | Inf | 0.883 | 0.983 | 0.559 | 0.882 | 2.81 | 0.931 | 0.000333 | NA |
HCC70 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 1 72 | 8 | 1.387 | 10.4 | 0.487 | 0.159 | 0.247 | 0.497 | 1.34 | 0.963 | 5.14e-05 | NA | Inf | 0.663 | 0.894 | 0.23 | 0.672 | 1.39 | 0.961 | 6.01e-05 | NA |
HCC70 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 2 72 | 8 | 1.771 | 6.13 | 0.558 | 0.126 | 1.21 | 0.339 | 0.698 | 0.981 | 7.24e-06 | NA | 785.0 | 0.643 | 0.894 | 0.946 | 0.496 | 0.708 | 0.978 | 1.04e-05 | NA |
HCC38 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC38 AS-605240 0 1 72 | 8 | 1.744 | Inf | 0.734 | 0.0803 | 0.448 | 0.691 | 0.881 | 0.969 | 2.92e-05 | NA | Inf | 0.78 | 0.932 | 0.405 | 0.748 | 0.895 | 0.967 | 3.48e-05 | NA |
BT-549 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT549 AS-605240 0 3 72 | 8 | 1.796 | Inf | 0.863 | 0.066 | 4.3 | 0.721 | 0.307 | 0.896 | 0.00112 | NA | Inf | 0.881 | 0.942 | 4.35 | 0.756 | 0.302 | 0.894 | 0.00118 | NA |