Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
Download: Excel (XLSX), Comma-separated (CSV)
Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HCC70 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 2 72 | 8 | 1.682 | 0.00746 | -0.705 | 1.01 | 0.0241 | -0.703 | 0.749 | 0.991 | 6.69e-07 | NA | 0.0135 | 0.0399 | 0.359 | 0.0121 | 0.0458 | 0.852 | 0.989 | 1.45e-06 | NA |
HCC70 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 3 72 | 8 | 2.458 | 0.0158 | -0.404 | 0.771 | 0.0319 | -0.379 | 0.8 | 0.99 | 8.95e-07 | NA | 0.0148 | 0.051 | 0.376 | 0.0127 | 0.0733 | 1.02 | 0.996 | 4.59e-08 | NA |
HCC70 | KIN001-244 | 1 | 72 | flat | flat | HCC70 KIN001-244 0 1 72 | 8 | 1.350 | Inf | 0.889 | 0.00722 | 0.0 | 0.889 | 0.01 | 0.616 | 0.0568 | 0.988 | Inf | 0.926 | 0.995 | 0.0 | 0.926 | 0.01 | 0.612 | 0.0584 | 0.992 |
HCC70 | KIN001-244 | 2 | 72 | flat | flat | HCC70 KIN001-244 0 2 72 | 8 | 1.684 | Inf | 0.898 | -0.0201 | 0.0 | 0.898 | 0.01 | 0.508 | 0.119 | 1.01 | Inf | 0.916 | 1.02 | 0.0 | 0.916 | 0.01 | -0.0458 | 1.0 | 1.01 |
HCC70 | KIN001-244 | 3 | 72 | flat | flat | HCC70 KIN001-244 0 3 72 | 8 | 2.472 | Inf | 0.916 | 0.0295 | 0.0 | 0.916 | 0.01 | -0.0208 | 1.0 | 0.969 | Inf | 0.899 | 0.965 | 0.0 | 0.899 | 0.01 | -0.00883 | 1.0 | 0.963 |
HCC70 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 1 72 | 8 | 1.444 | 0.314 | -0.0266 | 0.337 | 0.618 | -0.336 | 0.758 | 0.991 | 6.35e-07 | NA | 0.925 | 0.353 | 0.775 | 0.521 | 0.172 | 0.737 | 0.99 | 1.08e-06 | NA |
HCC70 | MK2206 | 2 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 2 72 | 8 | 1.690 | 0.446 | 0.244 | 0.2 | 0.301 | 0.226 | 1.53 | 0.973 | 1.92e-05 | NA | 1.03 | 0.448 | 0.851 | 0.266 | 0.44 | 1.56 | 0.965 | 4.11e-05 | NA |
HCC70 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 3 72 | 8 | 2.378 | 1.43 | 0.423 | 0.139 | 0.451 | 0.39 | 1.31 | 0.983 | 5.28e-06 | NA | 1.47 | 0.445 | 0.859 | 0.349 | 0.437 | 1.44 | 0.977 | 1.2e-05 | NA |
HCC70 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 1 72 | 8 | 1.305 | 1.04 | -0.0102 | 0.104 | 1.14 | -0.107 | 2.26 | 0.957 | 7.9e-05 | NA | 1.83 | 0.399 | 0.938 | 1.08 | 0.349 | 2.28 | 0.949 | 0.000133 | NA |
HCC70 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 2 72 | 8 | 1.739 | 1.19 | 0.0238 | 0.151 | 2.67 | -0.766 | 1.15 | 0.997 | 2.59e-08 | NA | 1.68 | 0.312 | 0.885 | 1.68 | 0.0 | 1.21 | 0.996 | 6.86e-08 | NA |
HCC70 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 3 72 | 8 | 2.446 | 1.51 | 0.227 | 0.0983 | 1.57 | -0.0288 | 1.54 | 0.986 | 2.66e-06 | NA | 1.48 | 0.303 | 0.906 | 1.15 | 0.168 | 1.59 | 0.976 | 1.42e-05 | NA |
HCC70 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 1 72 | 8 | 1.442 | 3.47 | 0.482 | 0.137 | 18.6 | -1.0 | 0.656 | 0.774 | 0.0116 | NA | 10.7 | 0.649 | 0.904 | 10.7 | 0.0 | 0.632 | 0.746 | 0.0163 | NA |
HCC70 | PIK-93 | 2 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 2 72 | 8 | 1.705 | 4.34 | 0.647 | 0.0132 | 9.3 | -1.0 | 1.44 | 0.888 | 0.0014 | NA | 6.01 | 0.718 | 0.991 | 6.01 | 0.0 | 1.49 | 0.872 | 0.00208 | NA |
HCC70 | PIK-93 | 3 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 3 72 | 8 | 2.519 | 21.2 | 0.756 | 0.0663 | 181.0 | -1.0 | 0.513 | 0.851 | 0.00333 | NA | 34.1 | 0.721 | 0.92 | 34.1 | 0.0 | 0.473 | 0.831 | 0.00487 | NA |
HCC70 | Sirolimus | 1 | 72 | sigmoid | sigmoid | HCC70 rapamycin 0 1 72 | 8 | 1.416 | 37.6 | 0.533 | 0.397 | 0.00426 | 0.298 | 0.1 | 0.742 | 0.0172 | NA | 125000000.0 | 0.687 | 0.732 | 0.00186 | 0.541 | 0.1 | 0.74 | 0.0175 | NA |
HCC70 | Sirolimus | 2 | 72 | flat | flat | HCC70 rapamycin 0 2 72 | 8 | 1.762 | Inf | 0.685 | 0.257 | 0.0 | 0.685 | 0.01 | 0.531 | 0.103 | 0.741 | Inf | 0.739 | 0.785 | 0.0 | 0.739 | 0.01 | 0.524 | 0.108 | 0.783 |
HCC70 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC70 rapamycin 0 3 72 | 8 | 2.548 | 310.0 | 0.732 | 0.227 | 0.000433 | 0.63 | 0.1 | 0.676 | 0.034 | NA | 22876.0 | 0.693 | 0.736 | 0.000237 | 0.58 | 0.1 | 0.659 | 0.0397 | NA |
HCC70 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 1 72 | 8 | 1.381 | 0.539 | 0.344 | 0.244 | 0.245 | 0.278 | 1.03 | 0.986 | 2.58e-06 | NA | Inf | 0.578 | 0.84 | 0.229 | 0.536 | 1.02 | 0.986 | 2.87e-06 | NA |
HCC70 | TGX221 | 2 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 2 72 | 8 | 1.786 | 1.77 | 0.467 | 0.233 | 0.531 | 0.227 | 0.503 | 0.948 | 0.000139 | NA | 5.85 | 0.575 | 0.806 | 3.44 | 0.0897 | 0.372 | 0.937 | 0.000249 | NA |
HCC70 | TGX221 | 3 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 3 72 | 8 | 2.459 | Inf | 0.7 | 0.0886 | 0.338 | 0.675 | 1.11 | 0.971 | 2.48e-05 | NA | Inf | 0.671 | 0.9 | 0.295 | 0.648 | 1.13 | 0.966 | 3.94e-05 | NA |
HCC70 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 1 72 | 8 | 1.345 | 0.0472 | 0.15 | 0.487 | 0.0311 | 0.149 | 0.849 | 0.973 | 1.89e-05 | NA | 0.93 | 0.475 | 0.693 | 0.0276 | 0.475 | 0.854 | 0.973 | 2.05e-05 | NA |
HCC70 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 2 72 | 8 | 1.726 | 0.107 | 0.323 | 0.391 | 0.0276 | 0.322 | 0.762 | 0.997 | 2.34e-08 | NA | 3.98 | 0.49 | 0.694 | 0.0225 | 0.491 | 0.775 | 0.997 | 1.93e-08 | NA |
HCC70 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 3 72 | 8 | 2.415 | 3.74 | 0.495 | 0.279 | 0.0352 | 0.496 | 1.02 | 0.994 | 2.6e-07 | NA | 5.73 | 0.495 | 0.709 | 0.0284 | 0.498 | 1.06 | 0.994 | 2.26e-07 | NA |
HCC70 | Torin2 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin2 0 1 72 | 8 | 1.364 | 0.0288 | -0.732 | 0.772 | 0.183 | -1.0 | 0.594 | 0.991 | 6.58e-07 | NA | 0.088 | 0.0644 | 0.539 | 0.088 | 0.0 | 0.622 | 0.988 | 1.95e-06 | NA |
HCC70 | Torin2 | 2 | 72 | sigmoid | sigmoid | HCC70 Torin2 0 2 72 | 8 | 1.826 | 0.0342 | -0.522 | 0.671 | 0.401 | -1.0 | 0.446 | 0.979 | 9.23e-06 | NA | 0.0639 | 0.0733 | 0.507 | 0.0639 | 0.0 | 0.462 | 0.969 | 2.98e-05 | NA |