Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
BT-549	KIN001-244	1	72	sigmoid	sigmoid	BT549 KIN001-244 0 1 72	8	1.802	Inf	0.872	0.0273	4.85	0.695	0.794	0.852	0.00324	NA	Inf	0.888	0.976	4.84	0.733	0.786	0.846	0.00362	NA
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
BT-20	MK2206	1	72	sigmoid	sigmoid	BT20 MK-2206 0 1 72	8	2.089	Inf	0.732	0.102	4.16	0.529	0.345	0.671	0.0357	NA	Inf	0.741	0.898	4.14	0.538	0.337	0.676	0.034	NA
BT-549	PI103	1	72	sigmoid	sigmoid	BT549 PI-103 0 1 72	8	1.795	0.206	0.0898	0.34	0.185	0.0628	1.25	0.997	2.96e-08	NA	0.348	0.336	0.737	0.155	0.318	1.25	0.996	8.76e-08	NA
BT-549	Dactolisib	1	72	sigmoid	sigmoid	BT549 dactolisib 0 1 72	8	1.840	0.00961	-0.00769	0.683	0.00888	0.0384	1.01	0.985	3.53e-06	NA	0.0161	0.275	0.482	0.0068	0.303	1.09	0.987	2.38e-06	NA
BT-20	Dactolisib	1	72	sigmoid	sigmoid	BT20 dactolisib 0 1 72	8	2.055	0.0223	-0.205	0.652	0.0609	-0.33	0.505	0.979	9.18e-06	NA	0.0305	0.15	0.475	0.0171	0.153	0.631	0.979	9.75e-06	NA
BT-549	PIK-93	1	72	sigmoid	sigmoid	BT549 PIK-93 0 1 72	8	1.777	Inf	0.691	0.0438	1.77	0.561	1.47	0.989	1.31e-06	NA	Inf	0.742	0.963	1.64	0.646	1.47	0.988	1.83e-06	NA
BT-549	Buparlisib	1	72	sigmoid	sigmoid	BT549 buparlisib 0 1 72	8	1.837	0.729	-0.325	0.253	1.83	-1.0	1.19	0.994	2.4e-07	NA	0.926	0.136	0.807	0.926	0.0	1.37	0.987	2.46e-06	NA
BT-20	PI103	1	72	sigmoid	sigmoid	BT20 PI-103 0 1 72	8	1.924	0.646	-0.0114	0.16	0.659	-0.0268	2.6	0.978	1.1e-05	NA	0.753	0.258	0.883	0.579	0.252	2.68	0.964	4.79e-05	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
BT-549	BX-912	1	72	sigmoid	sigmoid	BT549 BX-912 0 1 72	8	1.839	0.909	0.247	0.157	0.742	0.24	3.23	0.992	5.95e-07	NA	1.2	0.419	0.872	0.698	0.415	3.25	0.988	1.54e-06	NA
BT-20	CAL-101	1	72	flat	flat	BT20 idelalisib 0 1 72	8	2.112	Inf	0.869	0.0546	0.0	0.869	0.01	0.0807	0.777	0.938	Inf	0.867	0.943	0.0	0.867	0.01	0.0778	0.784	0.936
BT-549	TGX221	1	72	sigmoid	sigmoid	BT549 TGX-221 0 1 72	8	1.826	Inf	0.821	0.0771	0.297	0.777	0.632	0.868	0.00232	NA	Inf	0.842	0.931	0.313	0.799	0.603	0.863	0.00255	NA
BT-549	Alpelisib	1	72	flat	flat	BT549 alpelisib 0 1 72	8	1.822	Inf	0.747	0.0781	0.0	0.747	0.01	0.439	0.176	0.914	Inf	0.782	0.931	0.0	0.782	0.01	0.415	0.2	0.925
BT-20	PIK-93	1	72	sigmoid	sigmoid	BT20 PIK-93 0 1 72	8	2.025	2.65	0.406	0.0864	6.54	-1.0	1.22	0.993	3.89e-07	NA	3.15	0.49	0.92	3.15	0.0	1.31	0.989	1.33e-06	NA
HCC70	AZD-6482	1	72	sigmoid	sigmoid	HCC70 AZD6482 0 1 72	8	1.368	0.0982	0.0128	0.462	0.205	-0.212	0.481	0.975	1.49e-05	NA	0.767	0.394	0.704	0.121	0.305	0.509	0.973	1.9e-05	NA
BT-549	CAL-101	1	72	sigmoid	sigmoid	BT549 idelalisib 0 1 72	8	1.791	Inf	0.836	0.041	4.8	0.605	0.778	0.924	0.00044	NA	Inf	0.858	0.964	4.79	0.659	0.767	0.92	0.000518	NA
BT-20	AS605240	1	72	sigmoid	sigmoid	BT20 AS-605240 0 1 72	8	2.142	Inf	0.817	0.0993	3.91	0.634	0.244	0.861	0.00271	NA	Inf	0.814	0.897	3.87	0.629	0.237	0.854	0.00311	NA
BT-549	Trametinib	1	72	sigmoid	sigmoid	BT549 trametinib 0 1 72	8	1.812	Inf	0.596	0.202	0.131	0.523	0.61	0.959	6.65e-05	NA	28.3	0.664	0.828	3.47	0.254	0.337	0.933	0.000305	NA
BT-549	Everolimus	1	72	sigmoid	sigmoid	BT549 everolimus 0 1 72	8	1.772	5.64	0.503	0.444	1e-05	0.367	0.1	0.911	0.000706	NA	437200.0	0.603	0.641	0.000146	0.444	0.1	0.858	0.00286	NA
BT-20	Sirolimus	1	72	flat	flat	BT20 rapamycin 0 1 72	8	2.100	Inf	0.568	0.431	0.0	0.568	0.01	-9.89	1.0	0.568	Inf	0.6	0.601	0.0	0.6	0.01	-13.0	1.0	0.6
BT-549	Torin2	1	72	sigmoid	sigmoid	BT549 Torin2 0 1 72	8	1.771	0.0095	-0.218	0.756	0.0155	-0.193	0.672	0.985	3.06e-06	NA	0.0183	0.19	0.452	0.00874	0.218	0.775	0.988	1.88e-06	NA
HCC1806	Dactolisib	1	72	sigmoid	sigmoid	HCC1806 dactolisib 0 1 72	8	2.743	0.135	-0.0744	0.444	0.391	-0.425	0.577	0.986	2.81e-06	NA	0.0977	0.121	0.559	0.093	0.0151	0.619	0.986	2.47e-06	NA
HCC1806	AZD8055	1	72	sigmoid	sigmoid	HCC1806 AZD8055 0 1 72	8	2.732	Inf	0.534	0.247	0.0515	0.522	1.19	0.995	1.3e-07	NA	0.521	0.484	0.716	0.0427	0.471	1.15	0.996	7.15e-08	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)