Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	TGX221	1	72	flat	flat	BT20 TGX-221 0 1 72	8	1.988	Inf	1.02	-0.00357	0.0	1.02	0.01	-0.00762	1.0	1.0	Inf	1.02	1.0	0.0	1.02	0.01	-0.00881	1.0	1.0
BT-20	Buparlisib	1	72	sigmoid	sigmoid	BT20 buparlisib 0 1 72	8	2.131	0.598	-0.394	0.285	1.19	-0.763	1.35	0.992	4.68e-07	NA	0.663	0.0784	0.766	0.663	0.0	1.49	0.981	7.06e-06	NA
HCC38	MK2206	1	72	sigmoid	sigmoid	HCC38 MK-2206 0 1 72	8	1.789	19.4	0.698	0.0995	320.0	-0.949	0.38	0.956	8.33e-05	NA	61.8	0.746	0.914	61.8	0.0	0.386	0.951	0.000115	NA
BT-20	Torin1	1	72	sigmoid	sigmoid	BT20 Torin1 0 1 72	8	2.022	0.0383	-0.105	0.566	0.0658	-0.179	0.565	0.991	7.45e-07	NA	0.0591	0.197	0.536	0.0286	0.182	0.624	0.994	2.54e-07	NA
BT-20	Pictilisib	1	72	sigmoid	sigmoid	BT20 pictilisib 0 1 72	8	2.085	1.25	0.163	0.177	5.0	-1.0	0.791	0.994	1.75e-07	NA	1.52	0.323	0.838	1.52	0.0	0.865	0.989	1.22e-06	NA
BT-549	GDC-0980	1	72	sigmoid	sigmoid	BT549 apitolisib 0 1 72	8	1.781	0.19	0.113	0.333	0.16	0.1	1.27	0.999	4.05e-10	NA	0.328	0.352	0.744	0.132	0.347	1.31	0.999	7.05e-10	NA
BT-20	Torin2	1	72	sigmoid	sigmoid	BT20 Torin2 0 1 72	8	2.018	0.0185	-0.739	0.803	0.158	-1.0	0.511	0.986	2.9e-06	NA	0.0245	0.0164	0.415	0.0245	0.0	0.616	0.99	1.06e-06	NA
BT-20	AZD8055	1	72	sigmoid	sigmoid	BT20 AZD8055 0 1 72	8	2.117	0.0548	0.243	0.465	0.0266	0.213	0.768	0.984	4.08e-06	NA	0.0937	0.365	0.589	0.0198	0.335	0.713	0.982	5.4e-06	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
BT-20	Trametinib	1	72	sigmoid	sigmoid	BT20 trametinib 0 1 72	8	2.016	14.3	0.54	0.225	0.135	0.458	0.534	0.989	1.3e-06	NA	Inf	0.59	0.791	0.0955	0.534	0.545	0.989	1.43e-06	NA
BT-20	GDC-0980	1	72	sigmoid	sigmoid	BT20 apitolisib 0 1 72	8	2.001	0.0935	-0.289	0.498	0.128	-0.251	1.29	0.994	2.71e-07	NA	0.113	0.126	0.62	0.0885	0.151	1.48	0.996	7.34e-08	NA
BT-549	Omipalisib	1	72	sigmoid	sigmoid	BT549 omipalisib 0 1 72	8	1.789	0.0164	-0.2	0.693	0.0219	-0.149	0.887	0.986	2.66e-06	NA	0.0272	0.194	0.495	0.0148	0.228	0.993	0.991	8.42e-07	NA
BT-20	WYE-125132	1	72	sigmoid	sigmoid	BT20 WYE-132 0 1 72	8	2.067	0.0893	0.289	0.402	0.0435	0.256	1.0	0.987	2.28e-06	NA	0.154	0.403	0.647	0.0353	0.375	0.941	0.985	3.56e-06	NA
BT-20	BX-912	1	72	flat	flat	BT20 BX-912 0 1 72	8	2.193	Inf	0.858	0.0928	0.0	0.858	0.01	0.25	0.422	0.903	Inf	0.851	0.901	0.0	0.851	0.01	0.243	0.433	0.897
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
BT-20	XL147	1	72	flat	flat	BT20 pilaralisib 0 1 72	8	2.128	Inf	0.815	0.048	0.0	0.815	0.01	0.411	0.205	0.939	Inf	0.813	0.95	0.0	0.813	0.01	0.383	0.234	0.937
BT-20	Omipalisib	1	72	sigmoid	sigmoid	BT20 omipalisib 0 1 72	8	2.078	0.00617	-0.729	0.985	0.0283	-0.739	0.596	0.97	2.83e-05	NA	0.00781	0.0157	0.306	0.00685	0.0597	0.96	0.988	1.57e-06	NA
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
BT-20	ZSTK474	1	72	sigmoid	sigmoid	BT20 ZSTK474 0 1 72	8	1.940	0.788	0.0217	0.122	0.819	-0.0395	1.99	0.957	7.76e-05	NA	0.942	0.272	0.913	0.677	0.249	2.09	0.934	0.000293	NA
BT-20	AZD-6482	1	72	sigmoid	sigmoid	BT20 AZD6482 0 1 72	8	2.043	1.34	0.182	0.173	3.83	-0.782	0.893	0.982	5.6e-06	NA	1.65	0.342	0.845	1.65	0.0	0.977	0.972	2.09e-05	NA
BT-549	Dactolisib	1	72	sigmoid	sigmoid	BT549 dactolisib 0 1 72	8	1.840	0.00961	-0.00769	0.683	0.00888	0.0384	1.01	0.985	3.53e-06	NA	0.0161	0.275	0.482	0.0068	0.303	1.09	0.987	2.38e-06	NA
BT-549	AS605240	1	72	sigmoid	sigmoid	BT549 AS-605240 0 1 72	8	1.804	Inf	0.893	0.0436	4.49	0.778	0.375	0.862	0.00261	NA	Inf	0.905	0.961	4.52	0.804	0.371	0.861	0.00267	NA
BT-20	KIN001-244	1	72	flat	flat	BT20 KIN001-244 0 1 72	8	2.125	Inf	0.911	0.0401	0.0	0.911	0.01	-0.00641	1.0	0.957	Inf	0.908	0.958	0.0	0.908	0.01	-0.00745	1.0	0.955
HCC70	AZD8055	1	72	sigmoid	sigmoid	HCC70 AZD8055 0 1 72	8	1.339	0.0485	0.242	0.442	0.0243	0.26	1.06	0.976	1.32e-05	NA	Inf	0.529	0.721	0.0222	0.54	1.08	0.974	1.81e-05	NA
HCC70	AZD-6482	1	72	sigmoid	sigmoid	HCC70 AZD6482 0 1 72	8	1.368	0.0982	0.0128	0.462	0.205	-0.212	0.481	0.975	1.49e-05	NA	0.767	0.394	0.704	0.121	0.305	0.509	0.973	1.9e-05	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)