Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 WYE-125132 3 72
sigmoid
sigmoid
HCC70 WYE-132 0 3 72
 8 2.417
Inf
0.592
0.246
0.0209
0.606
1.64
0.995
1.48e-07
NA
Inf
0.576
0.739
0.019
0.588
1.64
0.996
7.52e-08
NA
HCC1806 CAL-101 3 72
flat
flat
HCC1806 idelalisib 0 3 72
 8 3.147
Inf
1.02
-0.00869
0.0
1.02
0.01
-0.594
1.0
1.01
Inf
1.03
1.01
0.0
1.03
0.01
-0.587
1.0
1.02
Hs 578T XL147 3
flat
flat
Hs578T pilaralisib 3
 8 2.879
Inf
0.971
-0.00618
0.0
0.971
0.01
0.331
0.299
1.0
Inf
0.959
1.01
0.0
0.959
0.01
0.319
0.315
1.0
HCC70 XL147 3 72
flat
flat
HCC70 pilaralisib 0 3 72
 8 2.478
Inf
1.03
-0.0199
0.0
1.03
0.01
-0.318
1.0
1.02
Inf
1.03
1.03
0.0
1.03
0.01
-0.331
1.0
1.02
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA