Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 2 72 | 8 | 1.983 | 7.03 | 0.687 | 0.0641 | 29.9 | -1.0 | 0.759 | 0.956 | 8.81e-05 | NA | 10.4 | 0.713 | 0.939 | 10.4 | 0.0 | 0.788 | 0.949 | 0.000136 | NA |
HCC1806 | MK2206 | 2 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 2 72 | 8 | 2.831 | 51.9 | 0.823 | 0.0489 | 320.0 | -0.668 | 0.467 | 0.981 | 7.01e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.45e-05 | NA |
BT-549 | Sirolimus | 2 | 72 | flat | flat | BT549 rapamycin 0 2 72 | 8 | 1.830 | Inf | 0.569 | 0.384 | 0.0 | 0.569 | 0.01 | 0.517 | 0.113 | 0.618 | Inf | 0.642 | 0.677 | 0.0 | 0.642 | 0.01 | 0.465 | 0.153 | 0.679 |
BT-549 | TGX221 | 2 | 72 | sigmoid | sigmoid | BT549 TGX-221 0 2 72 | 8 | 1.927 | 17.5 | 0.772 | 0.0551 | 123.0 | -1.0 | 0.562 | 0.907 | 0.000795 | NA | 32.3 | 0.792 | 0.949 | 32.3 | 3.45e-05 | 0.58 | 0.899 | 0.00102 | NA |
BT-549 | Torin1 | 2 | 72 | sigmoid | sigmoid | BT549 Torin1 0 2 72 | 8 | 1.881 | 0.0165 | 0.0298 | 0.618 | 0.0147 | 0.0572 | 1.03 | 0.993 | 4.2e-07 | NA | 0.0262 | 0.287 | 0.52 | 0.0111 | 0.306 | 1.1 | 0.99 | 9.68e-07 | NA |
HCC1806 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC1806 PI-103 0 2 72 | 8 | 2.758 | Inf | 0.898 | 0.00662 | 1.71 | 0.857 | 1.43 | 0.781 | 0.0105 | NA | Inf | 0.866 | 0.992 | 1.61 | 0.817 | 1.44 | 0.762 | 0.0134 | NA |
BT-549 | Torin2 | 2 | 72 | sigmoid | sigmoid | BT549 Torin2 0 2 72 | 8 | 1.824 | 0.00997 | -0.281 | 0.767 | 0.0212 | -0.282 | 0.594 | 0.975 | 1.47e-05 | NA | 0.0177 | 0.155 | 0.438 | 0.00929 | 0.188 | 0.734 | 0.973 | 2.02e-05 | NA |
BT-549 | Trametinib | 2 | 72 | sigmoid | sigmoid | BT549 trametinib 0 2 72 | 8 | 1.914 | Inf | 0.602 | 0.2 | 0.0685 | 0.581 | 0.837 | 0.995 | 1.05e-07 | NA | Inf | 0.654 | 0.822 | 0.0601 | 0.638 | 0.839 | 0.995 | 1.04e-07 | NA |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
BT-549 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | BT549 WYE-132 0 2 72 | 8 | 1.780 | 0.0329 | 0.0784 | 0.528 | 0.0287 | 0.0811 | 1.29 | 0.988 | 1.59e-06 | NA | 0.0545 | 0.333 | 0.604 | 0.0236 | 0.337 | 1.34 | 0.986 | 2.87e-06 | NA |
HCC1806 | PIK-93 | 2 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 2 72 | 8 | 2.838 | 41.1 | 0.857 | 0.038 | 265.0 | -1.0 | 0.59 | 0.858 | 0.00286 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
BT-549 | XL147 | 2 | 72 | flat | flat | BT549 pilaralisib 0 2 72 | 8 | 1.952 | Inf | 0.967 | -0.00824 | 0.0 | 0.967 | 0.01 | -0.000427 | 1.0 | 1.0 | Inf | 0.968 | 1.01 | 0.0 | 0.968 | 0.01 | -0.000878 | 1.0 | 1.0 |
BT-549 | ZSTK474 | 2 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 2 72 | 8 | 1.962 | 0.628 | 0.144 | 0.245 | 0.841 | -0.139 | 0.84 | 0.995 | 1.29e-07 | NA | 0.958 | 0.334 | 0.791 | 0.595 | 0.163 | 0.828 | 0.992 | 4.28e-07 | NA |
Hs 578T | Torin1 | 3 | sigmoid | sigmoid | Hs578T Torin1 3 | 8 | 2.860 | 0.0307 | 0.174 | 0.514 | 0.0196 | 0.176 | 0.964 | 0.999 | 2.01e-09 | NA | 0.0212 | 0.218 | 0.469 | 0.0119 | 0.222 | 1.02 | 0.998 | 1.17e-08 | NA | |
Hs 578T | GDC-0980 | 3 | sigmoid | sigmoid | Hs578T apitolisib 3 | 8 | 2.831 | 0.243 | 0.145 | 0.315 | 0.19 | 0.112 | 1.02 | 0.998 | 4.02e-09 | NA | 0.179 | 0.206 | 0.665 | 0.114 | 0.196 | 1.09 | 0.999 | 9.76e-10 | NA | |
HCC38 | AS605240 | 3 | 72 | flat | flat | HCC38 AS-605240 0 3 72 | 8 | 1.343 | Inf | 0.958 | -0.0162 | 0.0 | 0.958 | 0.01 | -0.233 | 1.0 | 1.01 | Inf | 0.972 | 1.01 | 0.0 | 0.972 | 0.01 | -0.235 | 1.0 | 1.01 |
BT-20 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 3 72 | 8 | 2.607 | Inf | 0.845 | 0.0823 | 4.13 | 0.662 | 0.292 | 0.729 | 0.0199 | NA | Inf | 0.81 | 0.897 | 3.97 | 0.589 | 0.284 | 0.712 | 0.0239 | NA |
Hs 578T | KIN001-244 | 3 | sigmoid | sigmoid | Hs578T KIN001-244 3 | 8 | 2.888 | Inf | 0.866 | 0.00909 | 5.05 | 0.617 | 1.35 | 0.858 | 0.00289 | NA | 50.0 | 0.818 | 0.988 | 5.2 | 0.474 | 1.31 | 0.842 | 0.00391 | NA | |
HCC38 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD6482 0 3 72 | 8 | 1.420 | Inf | 0.821 | 0.0615 | 0.324 | 0.826 | 5.0 | 0.849 | 0.00342 | NA | Inf | 0.875 | 0.957 | 0.323 | 0.879 | 5.0 | 0.846 | 0.00367 | NA |
HCC1806 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC1806 rapamycin 0 3 72 | 8 | 3.249 | 0.223 | 0.805 | 0.162 | 0.000183 | 0.746 | 0.1 | 0.663 | 0.0382 | NA | 1.05 | 0.717 | 0.76 | 1e-05 | 0.657 | 0.1 | 0.68 | 0.0328 | NA |
BT-549 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT549 AS-605240 0 3 72 | 8 | 1.796 | Inf | 0.863 | 0.066 | 4.3 | 0.721 | 0.307 | 0.896 | 0.00112 | NA | Inf | 0.881 | 0.942 | 4.35 | 0.756 | 0.302 | 0.894 | 0.00118 | NA |
HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |
Hs 578T | MK2206 | 3 | sigmoid | sigmoid | Hs578T MK-2206 3 | 8 | 2.883 | Inf | 0.737 | 0.0965 | 0.144 | 0.768 | 1.94 | 0.962 | 5.58e-05 | NA | Inf | 0.666 | 0.873 | 0.135 | 0.7 | 1.85 | 0.967 | 3.69e-05 | NA | |
BT-20 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 3 72 | 8 | 2.601 | 1.68 | 0.3 | 0.173 | 8.38 | -1.0 | 0.685 | 0.959 | 6.72e-05 | NA | 1.5 | 0.326 | 0.805 | 1.5 | 0.0 | 0.733 | 0.925 | 0.000414 | NA |
HCC38 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 3 72 | 8 | 1.468 | 0.0082 | -0.197 | 0.778 | 0.0127 | -0.181 | 0.711 | 0.993 | 3.98e-07 | NA | 0.0268 | 0.262 | 0.497 | 0.00923 | 0.277 | 0.757 | 0.994 | 2.62e-07 | NA |