Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Alpelisib	2	72	sigmoid	sigmoid	BT20 alpelisib 0 2 72	8	1.692	0.253	-0.0994	0.405	2.25	-1.0	0.503	0.835	0.00451	NA	0.612	0.259	0.698	0.612	0.0	0.507	0.764	0.0131	NA
HCC1806	AZD8055	2	72	sigmoid	sigmoid	HCC1806 AZD8055 0 2 72	8	2.817	Inf	0.546	0.24	0.0517	0.535	1.19	0.995	1.31e-07	NA	0.521	0.484	0.716	0.0427	0.471	1.15	0.996	7.15e-08	NA
BT-20	CAL-101	2	72	flat	flat	BT20 idelalisib 0 2 72	8	1.768	Inf	0.818	0.0943	0.0	0.818	0.01	0.226	0.463	0.898	Inf	0.845	0.918	0.0	0.845	0.01	0.222	0.471	0.912
BT-20	Everolimus	2	72	flat	flat	BT20 everolimus 0 2 72	8	1.785	Inf	0.426	0.574	0.0	0.426	0.01	NA	NA	0.426	Inf	0.547	0.547	0.0	0.547	0.01	NA	NA	0.547
Hs 578T	XL147	2		flat	flat	Hs578T pilaralisib 2	8	2.509	Inf	0.976	0.000255	0.0	0.976	0.01	0.435	0.181	0.997	Inf	0.97	1.0	0.0	0.97	0.01	0.432	0.183	0.996
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
HCC1806	Dactolisib	2	72	sigmoid	sigmoid	HCC1806 dactolisib 0 2 72	8	2.828	0.145	-0.0528	0.433	0.401	-0.401	0.578	0.986	2.83e-06	NA	0.0977	0.121	0.559	0.0929	0.0151	0.619	0.986	2.47e-06	NA
BT-20	GDC-0980	2	72	sigmoid	sigmoid	BT20 apitolisib 0 2 72	8	1.659	0.0456	-0.414	0.639	0.0629	-0.33	1.58	0.993	4.18e-07	NA	0.0641	0.131	0.575	0.0506	0.168	1.74	0.995	1.2e-07	NA
BT-20	Omipalisib	2	72	sigmoid	sigmoid	BT20 omipalisib 0 2 72	8	1.717	0.00324	-0.799	1.1	0.00361	-0.354	4.99	0.808	0.00704	NA	0.00518	0.0194	0.291	0.00429	0.111	1.34	0.968	3.16e-05	NA
Hs 578T	Pictilisib	2		sigmoid	sigmoid	Hs578T pictilisib 2	8	2.512	1.93	0.45	0.194	0.4	0.333	0.696	0.98	8e-06	NA	1.58	0.446	0.787	0.231	0.381	0.746	0.974	1.74e-05	NA
BT-20	KIN001-244	2	72	sigmoid	sigmoid	BT20 KIN001-244 0 2 72	8	1.742	Inf	0.85	0.0644	4.47	0.713	0.316	0.721	0.0218	NA	Inf	0.873	0.945	4.51	0.757	0.309	0.715	0.0231	NA
HCC1806	Buparlisib	2	72	sigmoid	sigmoid	HCC1806 buparlisib 0 2 72	8	2.827	0.759	-0.346	0.221	0.937	-0.392	2.75	1.0	2.72e-11	NA	0.69	0.0423	0.803	0.674	0.033	2.99	0.999	1.17e-09	NA
BT-20	MK2206	2	72	sigmoid	sigmoid	BT20 MK-2206 0 2 72	8	1.739	0.823	0.0896	0.246	4.34	-1.0	0.661	0.965	4.36e-05	NA	1.47	0.348	0.806	1.47	0.0	0.715	0.947	0.000145	NA
BT-20	PI103	2	72	sigmoid	sigmoid	BT20 PI-103 0 2 72	8	1.725	0.235	-0.21	0.388	0.289	-0.212	1.7	0.975	1.64e-05	NA	0.319	0.202	0.721	0.239	0.205	1.81	0.961	5.88e-05	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
HCC1806	BX-912	2	72	sigmoid	sigmoid	HCC1806 BX-912 0 2 72	8	2.825	0.992	0.159	0.14	0.888	0.141	2.99	0.999	3.32e-09	NA	0.894	0.214	0.854	0.753	0.205	3.07	0.997	2.86e-08	NA
BT-20	Sirolimus	2	72	flat	flat	BT20 rapamycin 0 2 72	8	1.952	Inf	0.421	0.579	0.0	0.421	0.01	NA	NA	0.421	Inf	0.513	0.513	0.0	0.513	0.01	NA	NA	0.513
BT-20	TGX221	2	72	flat	flat	BT20 TGX-221 0 2 72	8	1.656	Inf	1.0	0.0477	0.0	1.0	0.01	-0.101	1.0	0.946	Inf	1.0	0.961	0.0	1.0	0.01	-0.101	1.0	0.956
Hs 578T	Torin2	2		sigmoid	sigmoid	Hs578T Torin2 2	8	2.528	0.0153	-0.467	0.778	0.112	-0.771	0.47	0.986	2.55e-06	NA	0.0122	0.0353	0.352	0.0109	0.036	0.668	0.984	4.09e-06	NA
BT-20	Torin1	2	72	sigmoid	sigmoid	BT20 Torin1 0 2 72	8	1.793	0.00766	-0.152	0.806	0.00992	-0.146	0.986	0.986	2.59e-06	NA	0.0131	0.215	0.421	0.00727	0.212	0.936	0.988	1.92e-06	NA
HCC1806	Alpelisib	2	72	flat	flat	HCC1806 alpelisib 0 2 72	8	2.856	Inf	0.921	0.0566	0.0	0.921	0.01	-0.336	1.0	0.941	Inf	0.891	0.921	0.0	0.891	0.01	-0.351	1.0	0.919
BT-20	Torin2	2	72	sigmoid	sigmoid	BT20 Torin2 0 2 72	8	1.733	0.00315	-0.761	0.992	0.0484	-0.95	0.389	0.949	0.000131	NA	0.00804	0.0252	0.336	0.00642	0.0613	0.583	0.974	1.77e-05	NA
BT-20	Trametinib	2	72	sigmoid	sigmoid	BT20 trametinib 0 2 72	8	1.723	0.761	0.303	0.289	11.1	-0.768	0.347	0.965	4.13e-05	NA	2.56	0.478	0.77	2.56	0.0	0.362	0.957	8.16e-05	NA
Hs 578T	GDC-0980	2		sigmoid	sigmoid	Hs578T apitolisib 2	8	2.520	0.176	-0.0558	0.391	0.275	-0.201	0.758	0.997	3.91e-08	NA	0.159	0.151	0.627	0.121	0.1	0.818	0.998	1.45e-08	NA
BT-20	WYE-125132	2	72	sigmoid	sigmoid	BT20 WYE-132 0 2 72	8	2.053	0.012	0.142	0.633	0.00936	0.072	0.621	0.909	0.000752	NA	0.0232	0.316	0.475	0.00613	0.255	0.536	0.894	0.00119	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)