Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 WYE-125132 1 72
sigmoid
sigmoid
BT549 WYE-132 0 1 72
 8 1.787
0.0317
0.11
0.542
0.026
0.0962
1.09
0.996
5.11e-08
NA
0.062
0.349
0.589
0.0213
0.338
1.05
0.997
3.82e-08
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
HCC38 WYE-125132 3 72
sigmoid
sigmoid
HCC38 WYE-132 0 3 72
 8 1.449
0.0494
-0.0216
0.518
0.0504
-0.0117
1.18
0.998
9.69e-09
NA
0.128
0.355
0.662
0.0441
0.361
1.2
0.998
9.53e-09
NA
Hs 578T Trametinib 3
sigmoid
sigmoid
Hs578T trametinib 3
 8 2.830
0.0128
0.0657
0.644
0.0112
0.0447
0.702
0.998
4.02e-09
NA
0.00864
0.168
0.366
0.00512
0.157
0.722
0.998
5.57e-09
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
BT-549 Torin1 1 72
sigmoid
sigmoid
BT549 Torin1 0 1 72
 8 1.794
0.017
0.0603
0.621
0.0151
0.056
0.976
0.998
7.25e-09
NA
0.0333
0.32
0.532
0.0118
0.316
0.966
0.998
9.27e-09
NA
HCC38 Buparlisib 1 72
sigmoid
sigmoid
HCC38 buparlisib 0 1 72
 8 1.738
0.912
-0.226
0.194
1.46
-0.57
1.62
0.999
9.48e-10
NA
1.2
0.192
0.858
1.12
0.0495
1.66
0.998
4.36e-09
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
Hs 578T GDC-0980 2
sigmoid
sigmoid
Hs578T apitolisib 2
 8 2.520
0.176
-0.0558
0.391
0.275
-0.201
0.758
0.997
3.91e-08
NA
0.159
0.151
0.627
0.121
0.1
0.818
0.998
1.45e-08
NA
Hs 578T Trametinib 2
sigmoid
sigmoid
Hs578T trametinib 2
 8 2.483
0.00633
0.074
0.701
0.00558
0.0362
0.593
0.998
1.32e-08
NA
0.0058
0.214
0.361
0.00257
0.193
0.602
0.998
3.66e-09
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
Hs 578T GDC-0980 3
sigmoid
sigmoid
Hs578T apitolisib 3
 8 2.831
0.243
0.145
0.315
0.19
0.112
1.02
0.998
4.02e-09
NA
0.179
0.206
0.665
0.114
0.196
1.09
0.999
9.76e-10
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
Hs 578T ZSTK474 3
sigmoid
sigmoid
Hs578T ZSTK474 3
 8 2.863
0.913
0.31
0.201
0.613
0.143
0.846
0.999
6.21e-10
NA
0.607
0.298
0.767
0.329
0.211
0.895
0.999
1.43e-09
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA
Hs 578T AZD8055 2
sigmoid
sigmoid
Hs578T AZD8055 2
 8 2.480
0.0521
0.149
0.469
0.0387
0.142
1.13
0.999
3.49e-10
NA
0.0495
0.253
0.557
0.0273
0.249
1.16
0.999
4.45e-10
NA
HCC38 Torin1 3 72
sigmoid
sigmoid
HCC38 Torin1 0 3 72
 8 1.441
0.0231
-0.202
0.666
0.0412
-0.248
0.698
0.999
5.79e-10
NA
0.0787
0.266
0.572
0.0306
0.245
0.714
0.999
5.55e-10
NA
BT-549 Everolimus 2 72
flat
flat
BT549 everolimus 0 2 72
 8 1.909
Inf
0.566
0.407
0.0
0.566
0.01
-0.646
1.0
0.594
Inf
0.627
0.648
0.0
0.627
0.01
-1.01
1.0
0.649
HCC1806 TGX221 3 72
flat
flat
HCC1806 TGX-221 0 3 72
 8 3.132
Inf
1.0
-0.0101
0.0
1.0
0.01
-1.16
1.0
1.01
Inf
1.0
1.02
0.0
1.0
0.01
-1.16
1.0
1.02