Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
HCC38 Torin2 2 72
sigmoid
sigmoid
HCC38 Torin2 0 2 72
 8 2.140
0.0146
-0.48
0.793
0.0654
-0.634
0.545
0.993
3.78e-07
NA
0.0176
0.056
0.391
0.015
0.0502
0.68
0.989
1.33e-06
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
 8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
 8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
BT-549 Torin1 2 72
sigmoid
sigmoid
BT549 Torin1 0 2 72
 8 1.881
0.0165
0.0298
0.618
0.0147
0.0572
1.03
0.993
4.2e-07
NA
0.0262
0.287
0.52
0.0111
0.306
1.1
0.99
9.68e-07
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
BT-20 Dactolisib 3 72
sigmoid
sigmoid
BT20 dactolisib 0 3 72
 8 2.420
0.0111
0.024
0.639
0.00921
0.0987
1.17
0.982
6.27e-06
NA
0.0106
0.198
0.427
0.00645
0.241
1.32
0.99
9.14e-07
NA
BT-549 WYE-125132 3 72
sigmoid
sigmoid
BT549 WYE-132 0 3 72
 8 1.662
0.0271
0.0265
0.567
0.0245
0.0525
1.1
0.992
5.72e-07
NA
0.0574
0.33
0.592
0.0203
0.345
1.13
0.991
6.54e-07
NA
Hs 578T PIK-93 3
sigmoid
sigmoid
Hs578T PIK-93 3
 8 2.816
2.36
0.412
0.0884
2.23
0.033
1.2
0.994
1.87e-07
NA
1.89
0.375
0.897
1.42
0.149
1.24
0.991
8.33e-07
NA
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
HCC38 AZD8055 2 72
sigmoid
sigmoid
HCC38 AZD8055 0 2 72
 8 2.128
0.0616
0.16
0.467
0.045
0.124
0.912
0.993
3.13e-07
NA
0.0875
0.314
0.594
0.0332
0.284
0.869
0.991
6.5e-07
NA
BT-549 Omipalisib 3 72
sigmoid
sigmoid
BT549 omipalisib 0 3 72
 8 1.777
0.0114
-0.23
0.753
0.0162
-0.178
0.879
0.988
1.64e-06
NA
0.0201
0.183
0.459
0.0112
0.208
0.924
0.991
6.53e-07
NA
BT-549 BX-912 3 72
sigmoid
sigmoid
BT549 BX-912 0 3 72
 8 1.728
1.0
0.335
0.109
0.758
0.332
3.91
0.993
2.87e-07
NA
2.46
0.497
0.916
0.73
0.496
3.92
0.992
6.03e-07
NA
BT-549 GDC-0980 3 72
sigmoid
sigmoid
BT549 apitolisib 0 3 72
 8 1.802
0.162
0.0283
0.377
0.158
0.0179
1.2
0.994
2.53e-07
NA
0.268
0.302
0.709
0.128
0.294
1.2
0.992
4.85e-07
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA
HCC38 Pictilisib 1 72
sigmoid
sigmoid
HCC38 pictilisib 0 1 72
 8 1.759
7.16
0.562
0.125
1.04
0.377
0.725
0.992
5.12e-07
NA
Inf
0.647
0.896
0.797
0.529
0.742
0.992
5.77e-07
NA
BT-549 AZD-6482 1 72
sigmoid
sigmoid
BT549 AZD6482 0 1 72
 8 1.798
27.5
0.671
0.115
4.1
0.299
0.478
0.992
4.23e-07
NA
164.0
0.723
0.901
4.18
0.408
0.461
0.992
5.34e-07
NA